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The Changes of Intrinsic Excitability of Pyramidal Neurons in Anterior Cingulate Cortex in Neuropathic Pain.

التفاصيل البيبلوغرافية
العنوان: The Changes of Intrinsic Excitability of Pyramidal Neurons in Anterior Cingulate Cortex in Neuropathic Pain.
المؤلفون: Yang Z; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China., Tan Q; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China., Cheng D; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China., Zhang L; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China., Zhang J; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China., Gu EW; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China., Fang W; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China., Lu X; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China., Liu X; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China.
المصدر: Frontiers in cellular neuroscience [Front Cell Neurosci] 2018 Nov 21; Vol. 12, pp. 436. Date of Electronic Publication: 2018 Nov 21 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5102 (Print) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007-
مستخلص: To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic inputs and the intrinsic excitability. Previous studies have focused on the synaptic plasticity in different forms of pain. But little is known about the changes of neuronal intrinsic excitability in neuropathic pain. To address this question, whole-cell patch clamp recordings were performed to study the synaptic transmission and neuronal intrinsic excitability 1 week after spared nerve injury (SNI) or sham operation in male C57BL/6J mice. We found increased spontaneous excitatory postsynaptic currents (sEPSC) frequency in layer II/III pyramidal neurons of anterior cingulate cortex (ACC) from mice with neuropathic pain. Elevated intrinsic excitability of these neurons after nerve injury was also picked up, which was reflected in gain of input-output curve, inter-spike interval (ISI), spike threshold and Refractory period (RP). Besides firing rate related to neuronal intrinsic excitability, spike timing also plays an important role in neural information processing. The precision of spike timing measured by standard deviation of spike timing (SDST) was decreased in neuropathic pain state. The electrophysiological studies revealed the elevated intrinsic excitation in layer II/III pyramidal neurons of ACC in mice with neuropathic pain, which might contribute to central excitation.
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فهرسة مساهمة: Keywords: anterior cingulate cortex; intrinsic excitability; neuropathic pain; refractory period; spike threshold; spontaneous excitatory postsynaptic currents
تواريخ الأحداث: Date Created: 20181207 Latest Revision: 20201001
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6258991
DOI: 10.3389/fncel.2018.00436
PMID: 30519160
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-5102
DOI:10.3389/fncel.2018.00436