دورية أكاديمية
The role of dihydrosphingolipids in disease.
| العنوان: | The role of dihydrosphingolipids in disease. |
|---|---|
| المؤلفون: | Magaye RR; Monash Centre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Savira F; Monash Centre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Hua Y; Monash Centre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Kelly DJ; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, VIC, Australia., Reid C; Monash Centre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Flynn B; Australian Translational Medicinal Chemistry Facility, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia., Liew D; Monash Centre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Wang BH; Monash Centre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. bing.wang@monash.edu. |
| المصدر: | Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2019 Mar; Vol. 76 (6), pp. 1107-1134. Date of Electronic Publication: 2018 Dec 06. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basel : Springer Original Publication: Basel ; Boston : Birkhauser, c1997- |
| مواضيع طبية MeSH: | Cardiovascular Diseases/*metabolism , Ceramides/*metabolism , Diabetes Mellitus, Type 2/*metabolism , Obesity/*metabolism , Sphingolipids/*metabolism, Animals ; Apoptosis ; Autophagy ; Cardiovascular Diseases/pathology ; Ceramides/chemistry ; Diabetes Mellitus, Type 2/pathology ; Humans ; Molecular Structure ; Obesity/pathology ; Sphingolipids/chemistry |
| مستخلص: | Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph), dihydrosphingosine (dhSph), dihydrosphingosine-1-phosphate (dhS1P) and dihydroceramide (dhCer). Recent advances in research related to sphingolipid biochemistry have shed light on the importance of sphingolipids in terms of cellular signalling in health and disease. However, dihydrosphingolipids have received less attention and research is lacking especially in terms of their molecular mechanisms of action. This is despite studies implicating them in the pathophysiology of disease, for example dhCer in predicting type 2 diabetes in obese individuals, dhS1P in cardiovascular diseases and dhSph in hepato-renal toxicity. This review gives a comprehensive summary of research in the last 10-15 years on the dihydrosphingolipids, 3-ketoSph, dhSph, dhS1P and dhCer, and their relevant roles in different diseases. It also highlights gaps in research that could be of future interest. |
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| معلومات مُعتمدة: | 1092642 National Health and Medical Research Council; 1092642 National Health and Medical Research Council; 1092642 National Health and Medical Research Council; 1092642 National Health and Medical Research Council; 1087355 National Health and Medical Research Council |
| فهرسة مساهمة: | Keywords: 4-HRP fenretinide; Adipocyte; Aging; Airway hypersensitivity; Apoptosis; Autophagy; Cancer; Cardiomyopathy; Ceramide; Ceramide synthase; Diabetes; Dihydroceramide desaturase 1-Des-1; Dihydrosphinganine; FB1 toxicity; Hypoxia; Neurodegenerative; Serine palmitoyl transferase; Sphingosine kinase; Sphingosine-1-phosphate receptors; Sphingosine-1-phosphate—S1P |
| المشرفين على المادة: | 0 (Ceramides) 0 (Sphingolipids) 0 (dihydroceramide) |
| تواريخ الأحداث: | Date Created: 20181208 Date Completed: 20190325 Latest Revision: 20240522 |
| رمز التحديث: | 20240522 |
| مُعرف محوري في PubMed: | PMC11105797 |
| DOI: | 10.1007/s00018-018-2984-8 |
| PMID: | 30523364 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1007/s00018-018-2984-8 |