دورية أكاديمية
Cytotoxicity and selectiveness of Brazilian Piper species towards oral carcinoma cells.
| العنوان: | Cytotoxicity and selectiveness of Brazilian Piper species towards oral carcinoma cells. |
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| المؤلفون: | Macedo AL; Department of Organic Chemistry, Chemistry Institute, Fluminense Federal University, Niteroi, Brazil., da Silva DPD; Basic Science Department, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil., Moreira DL; Natural Products Department, Institute of Pharmaceutical Technology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., de Queiroz LN; Basic Science Department, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil., Vasconcelos TRA; Department of Organic Chemistry, Chemistry Institute, Fluminense Federal University, Niteroi, Brazil., Araujo GF; Postgraduate Program in Dentistry, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil., Kaplan MAC; Institute of Research in Natural Products, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Pereira SSC; Postgraduate Program in Dentistry, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil., de Almeida ECP; Basic Science Department, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil., Valverde AL; Department of Organic Chemistry, Chemistry Institute, Fluminense Federal University, Niteroi, Brazil. Electronic address: alessandravalverde@id.uff.br., Robbs BK; Basic Science Department, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil; Postgraduate Program in Dentistry, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil; Postgraduate Program in Applied Science for Health Products, Faculty of Pharmacy, Fluminense Federal University, Niteroi, Brazil. Electronic address: brunokr@id.uff.br. |
| المصدر: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2019 Feb; Vol. 110, pp. 342-352. Date of Electronic Publication: 2018 Dec 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Paris : Editions Scientifiques Elsevier Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982- |
| مواضيع طبية MeSH: | Piper*, Antineoplastic Agents, Phytogenic/*therapeutic use , Carcinoma, Squamous Cell/*drug therapy , Cytotoxins/*therapeutic use , Mouth Neoplasms/*drug therapy , Plant Extracts/*therapeutic use, Animals ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Brazil ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/physiology ; Cytotoxins/isolation & purification ; Cytotoxins/pharmacology ; Dose-Response Relationship, Drug ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mouth Neoplasms/pathology ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology |
| مستخلص: | Background: Oral squamous cell carcinoma (OSCC) is one of the ten most common types of cancer worldwide. Plants of the genusPiper are used in traditional medicine to treat cancer, and they have a vast diversity of phytochemicals with cytotoxic potential. Purpose and Study Design: In this work, we analyzed the cytotoxic and selective potential of extracts and semipurified fractions of Piper mollicomum (PM), Piper truncatum (PT), Piper cernuum (PC), Piper arboreum (PA), and Piper cabralanum (PCa) using three different OSCC cell lines (SCC4, SCC9 and SCC25), and we measured their in vivo toxicities and conducted chemical analyses of their active fractions. Results: The dichloromethane fractions of the crude methanolic extracts of the leaves of PM(-L-D), PC(-L-D) and PCa(-L-D) exhibited notable IC Conclusion: PC-L-D demonstrated great potential for further development as an anticancer drug and could be the key to developing more effective and less toxic therapies against oral cancer. (Copyright © 2018 The Authors. Published by Elsevier Masson SAS.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Acute toxicity; Chemical characterization; Cytotoxicity; Lignan; Oral cancer; Piperaceae |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Phytogenic) 0 (Cytotoxins) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20181212 Date Completed: 20190418 Latest Revision: 20190418 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.biopha.2018.11.129 |
| PMID: | 30529767 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1950-6007 |
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| DOI: | 10.1016/j.biopha.2018.11.129 |