دورية أكاديمية
Skin autofluorescence in children with and without obesity.
| العنوان: | Skin autofluorescence in children with and without obesity. |
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| المؤلفون: | Lentferink YE; Department of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands., van Teeseling L; Department of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands., Knibbe CAJ; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.; LACDR, Leiden University, Leiden, The Netherlands., van der Vorst MMJ; Department of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands. |
| المصدر: | Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2019 Jan 28; Vol. 32 (1), pp. 41-47. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 9508900 Publication Model: Print Cited Medium: Internet ISSN: 2191-0251 (Electronic) Linking ISSN: 0334018X NLM ISO Abbreviation: J Pediatr Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Mar. 2011- : Berlin : Walter de Gruyter Original Publication: London : Freund Pub. House, [1995- |
| مواضيع طبية MeSH: | Fluorescence*, Biomarkers/*metabolism , Glycation End Products, Advanced/*metabolism , Pediatric Obesity/*diagnosis , Skin/*metabolism, Adolescent ; Case-Control Studies ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Optical Imaging ; Pediatric Obesity/metabolism ; Prognosis ; Risk Assessment ; Skin/chemistry |
| مستخلص: | Background Obesity is associated with oxidative stress, which is related to increased advanced glycation end product (AGE) formation. AGEs accumulated in skin collagen can be measured with skin autofluorescence (sAF). There are conflicting reports on the influence of obesity on sAF in adults and no data in children. Therefore, this study evaluated sAF in pediatric patients with and without obesity. Methods In this cross-sectional study, participants aged 4-18 years were included: patients with obesity (body mass index standard deviation score [BMI-SDS] >2.3) and lean controls (BMI-SDS >-1.1 to <1.1). sAF was measured using the AGE Reader®. Participants were stratified according to age (<10, ≥10 to <13, ≥13 to <15, ≥15 to <17 and ≥17 years) and skin type (I-VI). Results In total, 143 patients and 428 controls were included. In patients, there was no influence of age on sAF (p=0.09). In controls, sAF was higher in children aged <10 years compared to ≥10 to <13 and ≥13 to <15 years (p=0.02; p=0.04). Stratified by age, sAF was higher in patients compared to controls in all age categories, except <10 years of age (p<0.01), while this was not observed when stratified by skin type (p>0.05). Skin type and BMI were significant covariates for sAF. Conclusions BMI was a covariate for sAF; however, no difference in sAF was observed between children with and without obesity, stratified by skin type. Duration of obesity as well as accuracy of the AGE Reader® might explain this difference. Further research is warranted, in which patients should be matched for age and skin type. |
| فهرسة مساهمة: | Keywords: advanced glycation end products; children; obesity; skin autofluorescence |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Glycation End Products, Advanced) |
| تواريخ الأحداث: | Date Created: 20181212 Date Completed: 20190708 Latest Revision: 20190708 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1515/jpem-2018-0237 |
| PMID: | 30530882 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2191-0251 |
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| DOI: | 10.1515/jpem-2018-0237 |