دورية أكاديمية
Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review).
| العنوان: | Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review). |
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| المؤلفون: | Gimba ERP; Program of Cellular and Molecular Oncobiology, National Cancer Institute, Rio de Janeiro 20231-050, Brazil., Brum MCM; Program of Cellular and Molecular Oncobiology, National Cancer Institute, Rio de Janeiro 20231-050, Brazil., Nestal De Moraes G; Cellular and Molecular Hemato-Oncology Laboratory, Molecular Hemato-Oncology Program, National Cancer Institute, Rio de Janeiro 20230-130, Brazil. |
| المصدر: | International journal of oncology [Int J Oncol] 2019 Feb; Vol. 54 (2), pp. 420-430. Date of Electronic Publication: 2018 Dec 06. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9306042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2423 (Electronic) Linking ISSN: 10196439 NLM ISO Abbreviation: Int J Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: Athens, Greece : D.A. Spandidos Original Publication: Athens, Greece : Lychnia, |
| مواضيع طبية MeSH: | Neoplasms/*drug therapy , Neoplasms/*radiotherapy , Osteopontin/*genetics , Protein Isoforms/*genetics, Apoptosis/genetics ; Autophagy/genetics ; Drug Resistance, Neoplasm/genetics ; Humans ; Neoplasms/genetics ; RNA Splicing/genetics ; Radiation Tolerance/genetics ; Signal Transduction |
| مستخلص: | Osteopontin (OPN) is a matricellular phosphoglycoprotein overexpressed in several tumor types and can activate several aspects of cancer progression in solid and non‑solid tumors. In the present review, the roles of OPN in mediating resistance to chemotherapy and radiotherapy and their main associated signaling pathways were summarized and discussed. Furthermore, it was detailed how OPN expression may be able to modulate resistance to these therapies by controlling epithelial cell plasticity, stemness potential and cell survival. Based on these data, the use of OPN and associated signaling was then proposed as potential molecular targets in order to sensitize resistant cells to main current therapeutic approaches. Finally, based on experimental evidence obtained by our group, the importance of investigating the specific roles OPN splicing isoforms have and how their properties may specifically control resistance to therapy was highlighted. These data elucidate a better understanding of how total OPN and their splicing isoforms, as well as their associated signaling, may contribute to main aspects of chemoresistance and radioresistance, such as those controlling cell survival, apoptosis, autophagy, stemness, epithelial cell plasticity and associated cell receptors. |
| فهرسة مساهمة: | Keywords: osteopontin; chemoresistance; radioresistance; splicing isoforms; signaling pathways |
| المشرفين على المادة: | 0 (Protein Isoforms) 106441-73-0 (Osteopontin) |
| تواريخ الأحداث: | Date Created: 20181212 Date Completed: 20190401 Latest Revision: 20211201 |
| رمز التحديث: | 20221213 |
| DOI: | 10.3892/ijo.2018.4656 |
| PMID: | 30535434 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1791-2423 |
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| DOI: | 10.3892/ijo.2018.4656 |