دورية أكاديمية
Circulating miRNA-375 as a potential novel biomarker for active Kaposi's sarcoma in AIDS patients.
العنوان: | Circulating miRNA-375 as a potential novel biomarker for active Kaposi's sarcoma in AIDS patients. |
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المؤلفون: | Piano MA; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Gianesello L; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Grassi A; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Del Bianco P; Clinical Trials and Biostatistics, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Mattiolo A; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Cattelan AM; Infectious and Tropical Diseases, Azienda Ospedaliera and University of Padova, Padova, Italy., Sasset L; Infectious Diseases, ULSS 18 - Azienda Ospedaliera, Rovigo, Italy., Zanovello P; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy., Calabrò ML; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy. |
المصدر: | Journal of cellular and molecular medicine [J Cell Mol Med] 2019 Feb; Vol. 23 (2), pp. 1486-1494. Date of Electronic Publication: 2018 Dec 13. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Oxford, England : Wiley-Blackwell Original Publication: Bucharest : "Carol Davila" University Press, 2000- |
مواضيع طبية MeSH: | Acquired Immunodeficiency Syndrome/*blood , HIV Infections/*blood , MicroRNAs/*blood , Sarcoma, Kaposi/*blood, Acquired Immunodeficiency Syndrome/pathology ; Acquired Immunodeficiency Syndrome/virology ; Adult ; Antiretroviral Therapy, Highly Active ; Biomarkers, Tumor/blood ; Circulating MicroRNA/blood ; Female ; HIV Infections/pathology ; HIV Infections/virology ; Herpesvirus 8, Human/pathogenicity ; Humans ; Male ; Middle Aged ; Sarcoma, Kaposi/pathology ; Sarcoma, Kaposi/virology |
مستخلص: | The aim of this study was to identify circulating microRNAs (miRNAs) that could be used as biomarkers in patients at risk for or affected by AIDS-Kaposi's sarcoma (KS). Screening of 377 miRNAs was performed using low-density arrays in pooled plasma samples of 10 HIV/human herpesvirus 8 (HHV8)-infected asymptomatic and 10 AIDS-KS patients before and after successful combined antiretroviral therapy (cART). MiR-375 was identified as a potential marker of active KS, being the most down-regulated in AIDS-KS patients after cART and the most up-regulated in naïve AIDS-KS patients compared to naïve asymptomatic subjects. Validation on individual plasma samples confirmed that miR-375 levels were higher in AIDS-KS compared to asymptomatic patients, decreased after cART-induced remission in most AIDS-KS patients and increased in patients with active KS. In asymptomatic patients miR-375 was up-regulated after cART in both screening and validation. Statistical analyses revealed an association between miR-375 changes and CD4 cell counts, which could explain the discordant cases and the opposite trend between asymptomatic and AIDS-KS patients. These data suggest that circulating miR-375 might be a good indicator of active AIDS-KS. Moreover, changes in miR-375 levels may have a prognostic value in HIV/HHV8-infected patients undergoing treatment. Further large-scale validation is needed. (© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.) |
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فهرسة مساهمة: | Keywords: HHV8; HIV; Kaposi’s sarcoma; biomarker; circulating miRNA; miR-375; microRNA |
المشرفين على المادة: | 0 (Biomarkers, Tumor) 0 (Circulating MicroRNA) 0 (MIRN375 microRNA, human) 0 (MicroRNAs) |
تواريخ الأحداث: | Date Created: 20181215 Date Completed: 20200617 Latest Revision: 20210109 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC6349189 |
DOI: | 10.1111/jcmm.14054 |
PMID: | 30549196 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1582-4934 |
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DOI: | 10.1111/jcmm.14054 |