دورية أكاديمية
أعرض في EDS

Circulating miRNA-375 as a potential novel biomarker for active Kaposi's sarcoma in AIDS patients.

التفاصيل البيبلوغرافية
العنوان: Circulating miRNA-375 as a potential novel biomarker for active Kaposi's sarcoma in AIDS patients.
المؤلفون: Piano MA; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Gianesello L; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Grassi A; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Del Bianco P; Clinical Trials and Biostatistics, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Mattiolo A; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy., Cattelan AM; Infectious and Tropical Diseases, Azienda Ospedaliera and University of Padova, Padova, Italy., Sasset L; Infectious Diseases, ULSS 18 - Azienda Ospedaliera, Rovigo, Italy., Zanovello P; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy., Calabrò ML; Immunology and Molecular Oncology, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy.
المصدر: Journal of cellular and molecular medicine [J Cell Mol Med] 2019 Feb; Vol. 23 (2), pp. 1486-1494. Date of Electronic Publication: 2018 Dec 13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, England : Wiley-Blackwell
Original Publication: Bucharest : "Carol Davila" University Press, 2000-
مواضيع طبية MeSH: Acquired Immunodeficiency Syndrome/*blood , HIV Infections/*blood , MicroRNAs/*blood , Sarcoma, Kaposi/*blood, Acquired Immunodeficiency Syndrome/pathology ; Acquired Immunodeficiency Syndrome/virology ; Adult ; Antiretroviral Therapy, Highly Active ; Biomarkers, Tumor/blood ; Circulating MicroRNA/blood ; Female ; HIV Infections/pathology ; HIV Infections/virology ; Herpesvirus 8, Human/pathogenicity ; Humans ; Male ; Middle Aged ; Sarcoma, Kaposi/pathology ; Sarcoma, Kaposi/virology
مستخلص: The aim of this study was to identify circulating microRNAs (miRNAs) that could be used as biomarkers in patients at risk for or affected by AIDS-Kaposi's sarcoma (KS). Screening of 377 miRNAs was performed using low-density arrays in pooled plasma samples of 10 HIV/human herpesvirus 8 (HHV8)-infected asymptomatic and 10 AIDS-KS patients before and after successful combined antiretroviral therapy (cART). MiR-375 was identified as a potential marker of active KS, being the most down-regulated in AIDS-KS patients after cART and the most up-regulated in naïve AIDS-KS patients compared to naïve asymptomatic subjects. Validation on individual plasma samples confirmed that miR-375 levels were higher in AIDS-KS compared to asymptomatic patients, decreased after cART-induced remission in most AIDS-KS patients and increased in patients with active KS. In asymptomatic patients miR-375 was up-regulated after cART in both screening and validation. Statistical analyses revealed an association between miR-375 changes and CD4 cell counts, which could explain the discordant cases and the opposite trend between asymptomatic and AIDS-KS patients. These data suggest that circulating miR-375 might be a good indicator of active AIDS-KS. Moreover, changes in miR-375 levels may have a prognostic value in HIV/HHV8-infected patients undergoing treatment. Further large-scale validation is needed.
(© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.)
References: Int J Cancer. 2014 Sep 1;135(5):1011-8. (PMID: 24166096)
Int J Clin Exp Med. 2015 May 15;8(5):7241-50. (PMID: 26221263)
Genome Biol. 2009;10(6):R64. (PMID: 19531210)
Cancer Lett. 2018 Dec 1;438:126-132. (PMID: 30237038)
Blood. 2009 Jun 4;113(23):5938-41. (PMID: 19252139)
Infect Agent Cancer. 2016 Feb 03;11:5. (PMID: 26848307)
J Acquir Immune Defic Syndr. 2004 Jun 1;36(2):702-13. (PMID: 15167289)
Int J Mol Sci. 2016 Apr 27;17(5):. (PMID: 27128908)
Cancer Res. 2010 Dec 1;70(23):9798-807. (PMID: 21098710)
Tumour Biol. 2015 Jan;36(1):437-46. (PMID: 25266797)
Clin Chem. 2010 Nov;56(11):1733-41. (PMID: 20847327)
Ann Intern Med. 2015 Oct 6;163(7):507-18. (PMID: 26436616)
PLoS Pathog. 2013;9(7):e1003484. (PMID: 23874201)
J Cell Mol Med. 2019 Feb;23(2):1486-1494. (PMID: 30549196)
J Invest Dermatol. 2014 Feb;134(2):507-517. (PMID: 23962809)
Clin Cancer Res. 2018 Dec 1;24(23):5873-5882. (PMID: 30061360)
Tumour Biol. 2015 Jun;36(6):4501-7. (PMID: 25618599)
Drug Deliv Transl Res. 2014 Feb;4(1):19-30. (PMID: 25786615)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
J Hum Virol. 1998 Mar-Apr;1(3):207-13. (PMID: 10195244)
Int J Oncol. 2005 Sep;27(3):779-85. (PMID: 16077928)
World J Gastroenterol. 2017 Jun 7;23(21):3864-3875. (PMID: 28638226)
J Clin Microbiol. 2005 Jun;43(6):2866-75. (PMID: 15956410)
Pathol Oncol Res. 2014 Jan;20(1):153-9. (PMID: 24027049)
Trends Biochem Sci. 2012 Nov;37(11):460-5. (PMID: 22944280)
فهرسة مساهمة: Keywords: HHV8; HIV; Kaposi’s sarcoma; biomarker; circulating miRNA; miR-375; microRNA
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (Circulating MicroRNA)
0 (MIRN375 microRNA, human)
0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20181215 Date Completed: 20200617 Latest Revision: 20210109
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6349189
DOI: 10.1111/jcmm.14054
PMID: 30549196
قاعدة البيانات: MEDLINE
الوصف
تدمد:1582-4934
DOI:10.1111/jcmm.14054