دورية أكاديمية

New Alkaloids and Anti-inflammatory Constituents from the Leaves of Antidesma ghaesembilla.

التفاصيل البيبلوغرافية
العنوان: New Alkaloids and Anti-inflammatory Constituents from the Leaves of Antidesma ghaesembilla.
المؤلفون: Van Kiem P, Cuong LCV, Trang DT, Nhiem NX, Anh HLT, Tai BH, Huong LM, Van Minh C, Lee TH, Kim SY, Kim SH
المصدر: Natural product communications [Nat Prod Commun] 2017 Jan; Vol. 12 (1), pp. 11-14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101477873 Publication Model: Print Cited Medium: Print ISSN: 1934-578X (Print) Linking ISSN: 15559475 NLM ISO Abbreviation: Nat Prod Commun Subsets: MEDLINE
أسماء مطبوعة: Publication: 2019- : [Thousand Oaks, CA] : SAGE Publications
Original Publication: Westerville, OH : Natural Product Communications, [2006]-[2018]
مواضيع طبية MeSH: Alkaloids/*analysis , Alkaloids/*pharmacology , Anti-Inflammatory Agents, Non-Steroidal/*pharmacology , Euphorbiaceae/*chemistry , Malpighiales/*chemistry , Plant Leaves/*chemistry, Animals ; Cell Line ; Lipopolysaccharides/pharmacology ; Magnetic Resonance Spectroscopy ; Mice ; Microglia/drug effects ; Microglia/metabolism ; Molecular Structure ; Nitric Oxide/biosynthesis ; Plant Extracts/chemistry ; Vietnam
مستخلص: Using various chromatographic methods, two new alkaloids, antidesoic acids A (1) and B (2) along with fourteen known compounds (3-16) were isolated from the leaves of Antidesma ghaesembilla Gaertn. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for their inhibitory activity on LPS-stimulated nitric oxide (NO) production in BV2 cells and RAW 264.7 macrophages. Bisflavone 8 significantly inhibited LPS- stimulated NO production in BV2 cells and RAW 264.7 macrophages with IC₅₀ values of 5.4 and 8.0 μM, respectively. Compounds 1-3, 7, 10, 12, 14, and 16 showed moderate inhibitory activities with IC₅₀ values ranging from 11.7 to 77.4 μM.
المشرفين على المادة: 0 (Alkaloids)
0 (Anti-Inflammatory Agents, Non-Steroidal)
0 (Lipopolysaccharides)
0 (Plant Extracts)
31C4KY9ESH (Nitric Oxide)
تواريخ الأحداث: Date Created: 20181215 Date Completed: 20190611 Latest Revision: 20190613
رمز التحديث: 20221213
PMID: 30549813
قاعدة البيانات: MEDLINE