دورية أكاديمية
Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study.
| العنوان: | Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study. |
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| المؤلفون: | Mathiesen JS; Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Kroustrup JP; Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark., Vestergaard P; Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark.; Steno Diabetes Center North Jutland, Aalborg, Denmark., Poulsen PL; Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark., Rasmussen ÅK; Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark., Feldt-Rasmussen U; Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark., Schytte S; Department of ORL Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark., Londero SC; Department of ORL Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark., Pedersen HB; Department of ORL Head & Neck Surgery, Aalborg University Hospital, Aalborg, Denmark., Hahn CH; Department of ORL Head & Neck Surgery, Copenhagen University Hospital, Copenhagen, Denmark., Bentzen J; Department of Oncology, Herlev Hospital, Herlev, Denmark., Möller S; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark., Gaustadnes M; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Rossing M; Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark., Nielsen FC; Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark., Brixen K; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Godballe C; Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark. |
| المصدر: | Endocrine connections [Endocr Connect] 2019 Jan 01; Vol. 8 (1), pp. 1-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioScientifica Country of Publication: England NLM ID: 101598413 Publication Model: Print Cited Medium: Print ISSN: 2049-3614 (Print) Linking ISSN: 20493614 NLM ISO Abbreviation: Endocr Connect Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol : BioScientifica |
| مستخلص: | A recent study proposed new TNM groupings for better survival discrimination among stage groups for medullary thyroid carcinoma (MTC) and validated these groupings in a population-based cohort in the United States. However, it is unknown how well the groupings perform in populations outside the United States. Consequently, we conducted the first population-based study aiming to evaluate if the recently proposed TNM groupings provide better survival discrimination than the current American Joint Committee on Cancer (AJCC) TNM staging system (seventh and eighth edition) in a nationwide MTC cohort outside the United States. This retrospective cohort study included 191 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. In multivariate analysis, hazard ratios for overall survival under the current AJCC TNM staging system vs the proposed TNM groupings with stage I as reference were 1.32 (95% CI: 0.38-4.57) vs 3.04 (95% CI: 1.38-6.67) for stage II, 2.06 (95% CI: 0.45-9.39) vs 3.59 (95% CI: 1.61-8.03) for stage III and 5.87 (95% CI: 2.02-17.01) vs 59.26 (20.53-171.02) for stage IV. The newly proposed TNM groupings appear to provide better survival discrimination in the nationwide Danish MTC cohort than the current AJCC TNM staging. Adaption of the proposed TNM groupings by the current AJCC TNM staging system may potentially improve accurateness in survival discrimination. However, before such an adaption further population-based studies securing external validity are needed. |
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| فهرسة مساهمة: | Keywords: endocrine cancers; rare diseases/syndromes; thyroid |
| تواريخ الأحداث: | Date Created: 20181215 Latest Revision: 20220331 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6330714 |
| DOI: | 10.1530/EC-18-0494 |
| PMID: | 30550378 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2049-3614 |
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| DOI: | 10.1530/EC-18-0494 |