دورية أكاديمية
أعرض في EDS

DETRIMENTS IN NEURON MORPHOLOGY FOLLOWING HEAVY ION IRRADIATION: WHAT'S THE TARGET?

التفاصيل البيبلوغرافية
العنوان: DETRIMENTS IN NEURON MORPHOLOGY FOLLOWING HEAVY ION IRRADIATION: WHAT'S THE TARGET?
المؤلفون: Cucinotta FA; Department of Health Physics and Diagnostic Sciences, University of Nevada Las Vegas, Las Vegas NV, USA., Eliedonna Cacao MA; Department of Health Physics and Diagnostic Sciences, University of Nevada Las Vegas, Las Vegas NV, USA.
المصدر: Radiation protection dosimetry [Radiat Prot Dosimetry] 2019 May 01; Vol. 183 (1-2), pp. 69-74.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8109958 Publication Model: Print Cited Medium: Internet ISSN: 1742-3406 (Electronic) Linking ISSN: 01448420 NLM ISO Abbreviation: Radiat Prot Dosimetry Subsets: MEDLINE
أسماء مطبوعة: Publication: 2004- : Oxford, UK : Oxford University Press
Original Publication: Ashford, Kent : Nuclear Technology Pub., c1981-
مواضيع طبية MeSH: Heavy Ion Radiotherapy*, DNA Damage/*radiation effects , Neurons/*radiation effects, Animals ; Cell Death/radiation effects ; Computer Simulation ; Dose-Response Relationship, Radiation ; Humans ; Linear Energy Transfer ; Models, Structural
مستخلص: Neuron cells consist of the soma or cell body, axons, dendritic arbor with multiple branches, and dendritic spines which are the substrates for memory storage and synaptic transmission. Detriments in neuron morphology are suggested to play a key role in cognitive impairments following brain irradiation. Multiple molecular mechanisms are involved in the regulation and stability of neuron morphology, while the effects of radiation on these processes have not been studied extensively. In this report, we consider possible biological targets in neurons for energy deposition (ED) by charged particles that could lead to neuron morphology detriments, and the resulting dose and radiation quality dependence of such detriments. The track structures of heavy ions including high charge and energy (HZE) particles consists of core of high-ED events and a penumbra of sparse ED from δ-ray electrons produced in ionization of target molecules. We consider the role of track structure relative to possible targets causative in the degradation of morphology.
(© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
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معلومات مُعتمدة: R01 CA208526 United States CA NCI NIH HHS
تواريخ الأحداث: Date Created: 20181219 Date Completed: 20190528 Latest Revision: 20200501
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6642454
DOI: 10.1093/rpd/ncy265
PMID: 30561664
قاعدة البيانات: MEDLINE
الوصف
تدمد:1742-3406
DOI:10.1093/rpd/ncy265