دورية أكاديمية
The availability of the α7 nicotinic acetylcholine receptor in recent-onset psychosis: a study using 18 F-ASEM PET.
| العنوان: | The availability of the α7 nicotinic acetylcholine receptor in recent-onset psychosis: a study using 18 F-ASEM PET. |
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| المؤلفون: | Coughlin J; Johns Hopkins Medical Institutions, United States., Du Y; Johns Hopkins Medical Institutions, United States., Crawford JL; Johns Hopkins Medical Institutions, United States., Rubin LH; Johns Hopkins Medical Institutions, United States., Behnam Azad B; Johns Hopkins Medical Institutions, United States., Lesniak WG; Johns Hopkins Medical Institutions, United States., Horti AG; Johns Hopkins Medical Institutions, United States., Schretlen DJ; Johns Hopkins Medical Institutions, United States., Sawa A; Johns Hopkins Medical Institutions, United States., Pomper MG; Johns Hopkins Medical Institutions, United States. |
| المصدر: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2018 Dec 20. Date of Electronic Publication: 2018 Dec 20. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med |
| أسماء مطبوعة: | Publication: Reston, VA : Society of Nuclear Medicine Original Publication: [Chicago, Ill.] : S.N. Turiel & Assoc. |
| مستخلص: | Limited postmortem evidence suggests a diminished availability of the α7 nicotinic acetylcholine receptor (α7-nAChR) in hippocampus in psychosis. Methods: In this cross-sectional PET study, we used 18 F-ASEM, a radiotracer targeting the α7-nAChR, with positron emission tomography to compare the binding of 18 F-ASEM in hippocampus between individuals with recent-onset psychosis and healthy controls. Results: Individuals with recent-onset psychosis [non-affective psychosis (NP) or affective psychosis], and particularly those with NP, showed lower hippocampal binding of 18 F-ASEM than healthy controls. Among patients, lower binding was associated with lower performance in two cognitive domains after controlling for age. Conclusion: Low availability of the α7-nAChR in hippocampus may be linked to recent-onset of psychosis. Further study is needed to assess its clinical relationship to neuropsychiatric symptoms. (Copyright © 2018 by the Society of Nuclear Medicine and Molecular Imaging, Inc.) |
| فهرسة مساهمة: | Keywords: &[alpha]7 nicotinic acetylcholine receptor; 18F-ASEM; Molecular Imaging; Neurology; PET; hippocampus; recent-onset psychosis |
| تواريخ الأحداث: | Date Created: 20181222 Latest Revision: 20240227 |
| رمز التحديث: | 20240227 |
| DOI: | 10.2967/jnumed.118.213686 |
| PMID: | 30573639 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1535-5667 |
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| DOI: | 10.2967/jnumed.118.213686 |