دورية أكاديمية
أعرض في EDS

Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine.

التفاصيل البيبلوغرافية
العنوان: Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine.
المؤلفون: Skibinski DAG; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore.; A*STAR Program in Translational Research on Infectious Disease, Agency for Science, Technology and Research, Singapore, Singapore., Jones LA; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore., Zhu YO; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Xue LW; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore., Au B; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore., Lee B; Singapore Immunology Network (SIgN), 8A Biomedical Grove, Immunos Bldg, Singapore, 138648, Singapore., Naim ANM; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Lee A; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore., Kaliaperumal N; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore., Low JGH; SingHealth Investigational Medicine Unit, Singapore General Hospital, Block 7, Outram Rd., Singapore, 169610, Singapore.; Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore., Lee LS; Clinical Trials Research Unit, Changi General Hospital, 2 Simei St. 3, Singapore, 529889, Singapore.; National University of Singapore, Department of Medicine, 1E Kent Ridge Road, Singapore, 119228, Singapore., Poidinger M; Singapore Immunology Network (SIgN), 8A Biomedical Grove, Immunos Bldg, Singapore, 138648, Singapore., Saudan P; Cytos Biotechnology AG, Wagistr. 25, Zürich-Schlieren, CH-8952, Switzerland., Bachmann M; Inselspital, RIA, Immunologie, Sahlihaus 2, CH-3010, Bern, Switzerland., Ooi EE; Duke-NUS Medical School, Program in Emerging Infectious Diseases, 8 College Rd., Singapore, 169857, Singapore., Hanson BJ; DSO National Laboratories, Bio-Defense Therapeutics Lab, 27 Medical Drive, Singapore, 117510, Singapore., Novotny-Diermayr V; D3 (Drug Discovery and Development), 31 Biopolis Way, #01-02a Nanos, Singapore, 138669, Singapore., Matter A; D3 (Drug Discovery and Development), 31 Biopolis Way, #01-02a Nanos, Singapore, 138669, Singapore., Fairhurst AM; Singapore Immunology Network (SIgN), 8A Biomedical Grove, Immunos Bldg, Singapore, 138648, Singapore., Hibberd ML; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Connolly JE; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore. jeconnolly@imcb.a-star.edu.sg.; A*STAR Program in Translational Research on Infectious Disease, Agency for Science, Technology and Research, Singapore, Singapore. jeconnolly@imcb.a-star.edu.sg.; Institute of Biomedical Studies, Baylor University, Waco, Texas, 76712, USA. jeconnolly@imcb.a-star.edu.sg.
المصدر: Scientific reports [Sci Rep] 2018 Dec 20; Vol. 8 (1), pp. 18007. Date of Electronic Publication: 2018 Dec 20.
نوع المنشور: Clinical Trial, Phase I; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: CD4-Positive T-Lymphocytes/*physiology , CD8-Positive T-Lymphocytes/*physiology , Cytokines/*metabolism , Influenza Vaccines/*immunology , Influenza, Human/*prevention & control , Lymphocyte Activation/*immunology, Adult ; Antibody Formation ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Cohort Studies ; Female ; Humans ; Immunity, Cellular/immunology ; Influenza, Human/immunology ; Influenza, Human/metabolism ; Male ; Middle Aged ; Vaccination ; Young Adult
مستخلص: Cell mediated immunity plays a vital role in defense against influenza infection in humans. Less is known about the role of vaccine-induced cell mediated immunity and the cytokine responses elicited. We measured CD4 + and CD8 + T-cell reactivity in human subjects following vaccination with licensed trivalent influenza vaccine and a novel virus-like particle based vaccine. We detected influenza-specific CD4 + T-cell responses following vaccination with the licensed trivalent influenza vaccine and found that these correlated with antibody measurements. Administration of the novel virus-like particle based vaccine elicited influenza-specific CD4 + and CD8 + T-cell responses and the induction of the cytokines IFN-γ, IL-17A, IL17F, IL-5, IL-13, IL-9, IL-10 and IL-21. Pre-existing cytokine responses influenced the profile of the cytokine response elicited by vaccination. In a subset of individuals the VLP vaccine changed pre-vaccination production of type 2 cytokines such as IL-5 and IL-13 to a post-vaccination type 1 cytokine signature characterized by IFN-γ. A transcriptional signature to vaccination was found to correlate with antibody titer, IFN-γ production by T-cells and expression of a putative RNA helicase, DDX17, on the surface of immune cells.
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المشرفين على المادة: 0 (Cytokines)
0 (Influenza Vaccines)
تواريخ الأحداث: Date Created: 20181222 Date Completed: 20191202 Latest Revision: 20200309
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6301966
DOI: 10.1038/s41598-018-36703-7
PMID: 30573748
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-018-36703-7