دورية أكاديمية
Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine.
العنوان: | Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine. |
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المؤلفون: | Skibinski DAG; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore.; A*STAR Program in Translational Research on Infectious Disease, Agency for Science, Technology and Research, Singapore, Singapore., Jones LA; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore., Zhu YO; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Xue LW; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore., Au B; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore., Lee B; Singapore Immunology Network (SIgN), 8A Biomedical Grove, Immunos Bldg, Singapore, 138648, Singapore., Naim ANM; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Lee A; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore., Kaliaperumal N; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore., Low JGH; SingHealth Investigational Medicine Unit, Singapore General Hospital, Block 7, Outram Rd., Singapore, 169610, Singapore.; Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore., Lee LS; Clinical Trials Research Unit, Changi General Hospital, 2 Simei St. 3, Singapore, 529889, Singapore.; National University of Singapore, Department of Medicine, 1E Kent Ridge Road, Singapore, 119228, Singapore., Poidinger M; Singapore Immunology Network (SIgN), 8A Biomedical Grove, Immunos Bldg, Singapore, 138648, Singapore., Saudan P; Cytos Biotechnology AG, Wagistr. 25, Zürich-Schlieren, CH-8952, Switzerland., Bachmann M; Inselspital, RIA, Immunologie, Sahlihaus 2, CH-3010, Bern, Switzerland., Ooi EE; Duke-NUS Medical School, Program in Emerging Infectious Diseases, 8 College Rd., Singapore, 169857, Singapore., Hanson BJ; DSO National Laboratories, Bio-Defense Therapeutics Lab, 27 Medical Drive, Singapore, 117510, Singapore., Novotny-Diermayr V; D3 (Drug Discovery and Development), 31 Biopolis Way, #01-02a Nanos, Singapore, 138669, Singapore., Matter A; D3 (Drug Discovery and Development), 31 Biopolis Way, #01-02a Nanos, Singapore, 138669, Singapore., Fairhurst AM; Singapore Immunology Network (SIgN), 8A Biomedical Grove, Immunos Bldg, Singapore, 138648, Singapore., Hibberd ML; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Connolly JE; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore. jeconnolly@imcb.a-star.edu.sg.; A*STAR Program in Translational Research on Infectious Disease, Agency for Science, Technology and Research, Singapore, Singapore. jeconnolly@imcb.a-star.edu.sg.; Institute of Biomedical Studies, Baylor University, Waco, Texas, 76712, USA. jeconnolly@imcb.a-star.edu.sg. |
المصدر: | Scientific reports [Sci Rep] 2018 Dec 20; Vol. 8 (1), pp. 18007. Date of Electronic Publication: 2018 Dec 20. |
نوع المنشور: | Clinical Trial, Phase I; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | CD4-Positive T-Lymphocytes/*physiology , CD8-Positive T-Lymphocytes/*physiology , Cytokines/*metabolism , Influenza Vaccines/*immunology , Influenza, Human/*prevention & control , Lymphocyte Activation/*immunology, Adult ; Antibody Formation ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Cohort Studies ; Female ; Humans ; Immunity, Cellular/immunology ; Influenza, Human/immunology ; Influenza, Human/metabolism ; Male ; Middle Aged ; Vaccination ; Young Adult |
مستخلص: | Cell mediated immunity plays a vital role in defense against influenza infection in humans. Less is known about the role of vaccine-induced cell mediated immunity and the cytokine responses elicited. We measured CD4 + and CD8 + T-cell reactivity in human subjects following vaccination with licensed trivalent influenza vaccine and a novel virus-like particle based vaccine. We detected influenza-specific CD4 + T-cell responses following vaccination with the licensed trivalent influenza vaccine and found that these correlated with antibody measurements. Administration of the novel virus-like particle based vaccine elicited influenza-specific CD4 + and CD8 + T-cell responses and the induction of the cytokines IFN-γ, IL-17A, IL17F, IL-5, IL-13, IL-9, IL-10 and IL-21. Pre-existing cytokine responses influenced the profile of the cytokine response elicited by vaccination. In a subset of individuals the VLP vaccine changed pre-vaccination production of type 2 cytokines such as IL-5 and IL-13 to a post-vaccination type 1 cytokine signature characterized by IFN-γ. A transcriptional signature to vaccination was found to correlate with antibody titer, IFN-γ production by T-cells and expression of a putative RNA helicase, DDX17, on the surface of immune cells. |
References: | Expert Rev Vaccines. 2012 Aug;11(8):949-62. (PMID: 23002976) J Virol. 2006 Dec;80(23):11756-66. (PMID: 16971435) J Infect Dis. 2011 Sep 15;204(6):845-53. (PMID: 21846636) Vaccine. 2014 Sep 3;32(39):5041-8. (PMID: 25045806) Sci Transl Med. 2013 Mar 13;5(176):176ra32. (PMID: 23486778) PLoS One. 2013 Nov 18;8(11):e78947. (PMID: 24260136) World J Gastroenterol. 2014 Jun 28;20(24):7971-8. (PMID: 24976734) Vaccine. 2012 Jun 29;30(31):4581-4. (PMID: 22554464) J Infect Dis. 2004 Dec 1;190(11):1927-35. (PMID: 15529256) Clin Vaccine Immunol. 2008 Jul;15(7):1042-53. (PMID: 18448618) J Exp Med. 2012 Mar 12;209(3):581-96. (PMID: 22370718) J Clin Immunol. 2011 Oct;31(5):900-12. (PMID: 21732013) Vaccine. 2010 Jul 5;28(30):4771-6. (PMID: 20470801) J Virol. 1996 Jul;70(7):4787-90. (PMID: 8676508) Nat Biotechnol. 2012 Dec;30(12):1210-6. (PMID: 23159882) J Infect Dis. 2013 Jan 15;207(2):297-305. (PMID: 23148285) Nat Med. 2012 Jan 29;18(2):274-80. (PMID: 22286307) Vaccine. 2008 Apr 7;26(16):1990-8. (PMID: 18339461) Vaccine. 2012 Aug 3;30(36):5407-16. (PMID: 22717330) PLoS One. 2011;6(6):e20928. (PMID: 21687743) Vaccine. 2010 Dec 6;28(52):8258-67. (PMID: 21050903) J Immunol. 2003 Sep 15;171(6):3163-9. (PMID: 12960344) Curr Top Microbiol Immunol. 2009;333:453-70. (PMID: 19768419) Nat Med. 2013 Oct;19(10):1305-12. (PMID: 24056771) Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14330-5. (PMID: 23940329) Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3877-82. (PMID: 19237568) Science. 2010 Aug 27;329(5995):1060-4. (PMID: 20647428) Nat Immunol. 2014 Feb;15(2):195-204. (PMID: 24336226) J Clin Immunol. 2015 Feb;35(2):100-7. (PMID: 25666293) PLoS One. 2013 Oct 18;8(10):e76571. (PMID: 24204639) Hum Vaccin Immunother. 2012 Apr;8(4):453-64. (PMID: 22370514) mBio. 2011 Aug 16;2(4):. (PMID: 21846828) Pediatr Infect Dis J. 2007 Feb;26(2):107-15. (PMID: 17259871) J Immunol. 2006 May 15;176(10):6333-9. (PMID: 16670345) Curr Top Microbiol Immunol. 1989;146:107-16. (PMID: 2659262) |
المشرفين على المادة: | 0 (Cytokines) 0 (Influenza Vaccines) |
تواريخ الأحداث: | Date Created: 20181222 Date Completed: 20191202 Latest Revision: 20200309 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC6301966 |
DOI: | 10.1038/s41598-018-36703-7 |
PMID: | 30573748 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-018-36703-7 |