دورية أكاديمية
Two New Cytotoxic Steroidal Alkaloids from Sarcococca Hookeriana .
| العنوان: | Two New Cytotoxic Steroidal Alkaloids from Sarcococca Hookeriana . |
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| المؤلفون: | Huo S; Guiyang College of Traditional Chinese Medicine, Guiyang 550025, China. 15038115764@163.com., Wu J; Guiyang College of Traditional Chinese Medicine, Guiyang 550025, China. wujichun2018@sina.com., He X; Guiyang College of Traditional Chinese Medicine, Guiyang 550025, China. hexicheng53@126.com., Pan L; Guizhou Provincial Key Laboratory of Miao Medicine, Guiyang 550025, China. ltpan@sina.cn., Du J; Guiyang College of Traditional Chinese Medicine, Guiyang 550025, China. dujang.gz@163.com.; Guizhou Provincial Key Laboratory of Miao Medicine, Guiyang 550025, China. dujang.gz@163.com. |
| المصدر: | Molecules (Basel, Switzerland) [Molecules] 2018 Dec 20; Vol. 24 (1). Date of Electronic Publication: 2018 Dec 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
| مواضيع طبية MeSH: | Buxaceae/*chemistry , Cell Survival/*drug effects , Steroids/*chemistry , Steroids/*pharmacology, Alkaloids/chemistry ; Alkaloids/pharmacology ; Cell Line, Tumor ; Crystallography, X-Ray ; Humans ; K562 Cells ; MCF-7 Cells ; PC-3 Cells |
| مستخلص: | Two new steroidal alkaloids, named hookerianine A ( 1 ) and hookerianine B ( 2 ) were isolated from the stems and roots of Sarcococca hookeriana Baill., along with two known compounds, sarcorucinine G ( 3 ) and epipachysamine D ( 4 ). On the basis of spectroscopic methods and by comparison with literature data, their structures were determined. As well as X-ray crystallography was performed to confirm compound 4 . To identify novel antitumor inhibitors, all compounds were performed a CCK-8 assay against five human cancer cell lines SW480, SMMC-7721, PC3, MCF-7 and K562 in vitro. Compound 2 exhibited moderate cytotoxic activities to all cell lines with IC |
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| معلومات مُعتمدة: | No. 2016-1015 Science and Technology Project of Guizhou Province; No. 30960529 National Natural Science Foundation of China |
| فهرسة مساهمة: | Keywords: Buxaceae; Sarcococca hookeriana; cytotoxicity; steroidal alkaloid |
| المشرفين على المادة: | 0 (Alkaloids) 0 (Steroids) |
| تواريخ الأحداث: | Date Created: 20181223 Date Completed: 20190219 Latest Revision: 20200225 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6337136 |
| DOI: | 10.3390/molecules24010011 |
| PMID: | 30577522 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1420-3049 |
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| DOI: | 10.3390/molecules24010011 |