دورية أكاديمية
DISEASES OF CIRCULATORY SYSTEM AND COMORBID TYPE II DIABETES MELLITUS IN THE CHORNOBYL ACCIDENT CONSEQUENCES CLEAN-UP WORKERS.
| العنوان: | DISEASES OF CIRCULATORY SYSTEM AND COMORBID TYPE II DIABETES MELLITUS IN THE CHORNOBYL ACCIDENT CONSEQUENCES CLEAN-UP WORKERS. |
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| عنوان ترانسليتريتد: | ZAKhVORIuVANNIa SYSTEMY KROVOOBIGU V UChASNYKIV LIKVIDATsIÏ NASLIDKIV ChORNOBYL'S'KOÏ AVARIÏ I KOMORBIDNA PATOLOGIIa U VYGLIaDI TsUKROVOGO DIABETU II TYPU. |
| المؤلفون: | Bazyka OD; State institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Melnykova str., Kyiv, 04050, Ukraine., Bilyi DO; State institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Melnykova str., Kyiv, 04050, Ukraine. |
| المصدر: | Problemy radiatsiinoi medytsyny ta radiobiolohii [Probl Radiac Med Radiobiol] 2018 Dec; Vol. 23, pp. 246-253. |
| نوع المنشور: | Journal Article |
| اللغة: | English; Ukrainian |
| بيانات الدورية: | Publisher: Naukovyĭ t︠s︡entr radiat︠s︡iĭnoï medyt︠s︡yny AMN Ukraïny Country of Publication: Ukraine NLM ID: 101560511 Publication Model: Print Cited Medium: Print ISSN: 2304-8336 (Print) Linking ISSN: 23048336 NLM ISO Abbreviation: Probl Radiac Med Radiobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kyïv : Naukovyĭ t︠s︡entr radiat︠s︡iĭnoï medyt︠s︡yny AMN Ukraïny |
| مواضيع طبية MeSH: | Chernobyl Nuclear Accident* , Emergency Responders*, Angina Pectoris/*epidemiology , Cardiovascular Diseases/*epidemiology , Diabetes Mellitus, Type 2/*epidemiology , Heart Failure/*epidemiology , Occupational Exposure/*adverse effects , Radiation Exposure/*adverse effects, Aged ; Angina Pectoris/etiology ; Angina Pectoris/physiopathology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Case-Control Studies ; Comorbidity ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/physiopathology ; Heart Failure/etiology ; Heart Failure/physiopathology ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Radiation Dosage ; Radiation Monitoring/methods ; Ukraine/epidemiology |
| مستخلص: | Objective: The study was focused on evaluation of peculiarities of the clinical manifestations of type II diabetesmellitus (TIIDM) in the Chornobyl nuclear power plant (ChNPP) accident clean-up workers (ACUW). Materials and Methods: The ChNPP ACUW of 1986-1987 period (n = 449, males) and 158 males not exposed to ion-izing radiation (the control group, CG) were involved in the study in 2013-2018. Diagnosis of cardiovascular disease(CVD) and type II diabetes mellitus (TIIDM) was established in accordance with diagnostic standards adopted inUkraine. All study subjects had no signs of CVD, and neither of endocrine disease nor of metabolic disorders beforethe accident. Results: Clinical course of the TIIDM, depending on the disease severity, onset of angiopathy and polyneuropathy,prevalence of angina pectoris and heart failure were surveyed and analyzed. Concomitant TIIDM was associated witha higher incidence of angina pectoris and heart failure. According to the Kaplan-Meier method of survival estimatingthe accumulation of new TIIDM cases occurred faster in the ACUW compared with individuals in the CG, however withno statistical significance in subjects aged up to 60 years old (log-rank test χ2 = 4.89, p = 0.027). Mean age of theACUW having comorbid CVD and DM was (54.6 ± 9.7) years, whilst in the CG it was (59.9 ± 10.7) years (p = 0.005). Conclusions: The DM course in the ACUW was not significantly different from non-irradiated control both in sever-ity and such complications as angiopathy of retina and lower extremities, as well as manifestations of lower extrem-ity polyneuropathy. Clinical manifestations of CVD in the form of angina pectoris and heart failure were identical inthe ACUW and control group of patients having a comorbid TIIDM. The latter was a factor exacerbating the CVDcourse and leading to a higher prevalence of angina pectoris and heart failure both in the ACUW and in non-irritat-ed individuals. Accumulation of the new DM cases occurred more rapidly in ACUW vs. non-irradiated control, so theywere in average 5 years younger at the time of TIIDM manifestation than the control subjects. (O. D. Bazyka, D. O. Bilyi.) |
| فهرسة مساهمة: | Keywords: Chernobyl nuclear power plant accident clean-up workers; cardiovascular disease; comorbidity; diabetes mellitus Local Abstract: [Publisher, Ukrainian] Meta doslidzhennia poliagala u vyznachenni osoblyvosteĭ klinichnykh proiaviv tsukrovogo diabetu (TsD) II typu sereduchasnykiv likvidatsiï naslidkiv avariï (ULNA) na Chornobyl's'kiĭ atomniĭ elektrostantsiï (ChAES).Materialy ta metody. Za period z 2013 po 2018 rr. obstezheno 449 cholovikiv-ULNA 1986–1987 rr. ta 158 patsi-ientiv cholovichoï stati, iaki ne zaznaly radiatsiĭnogo vplyvu (kontrol'na grupa – KG). Diagnoz sertsevo-sudynnykhzakhvoriuvan' (SSZ) ta TsD vstanovliuvaly u vidpovidnosti do standartiv diagnostyky, pryĭniatykh v Ukraïni. Doavariï vsi osoby, iaki uviĭshly v doslidzhennia, ne maly oznak SSZ ta endokrynnykh khvorob abo porushen' obminu re-chovyn.Rezul'taty. Buv provedenyĭ analiz klinichnogo perebigu TsD v zalezhnosti vid tiazhkosti zakhvoriuvannia, rozvytkuangio- i polineĭropatiĭ, poshyrenosti stenokardiï naprugy i sertsevoï nedostatnosti. Naiavnist' suputn'ogo TsD aso-tsiiuvala z bil'sh vysokoiu chastotoiu stenokardiï naprugy i sertsevoï nedostatnosti. Metodom otsinky vyzhyvanosti zaKaplanom-Meĭierom bulo vyiavleno, shcho nakopychennia novykh vypadkiv zaneduzhannia TsD vidznachalos' bil'sh vyso-kymy tempamy sered ULNA u porivnianni z osobamy KG, prote dostovirnist' vidminnosteĭ dynamiky nakopychenniasposterigalasia u vikovomu diapazoni vid 60 rokiv i nyzhche: log-rangovyĭ test – χ2 = 4,89 pry r = 0,027. Seredniĭvik ULNA z SSZ v poiednanni z TsD stanovyv (54,6 -#177; 9,7) rokiv, a patsiientiv KG – (59,9 -#177; 10,7) rokiv (r = 0,005).Vysnovky. Sered ULNA perebig TsD dostovirno ne vidrizniavsia vid neoprominenogo kontroliu po tiazhkosti proiavivi uskladnen', u vygliadi angiopatiï sudyn sitkivky i nyzhnikh kintsivok, a takozh polineĭropatiï nyzhnikh kintsivok.Klinichni proiavy SSZ u vygliadi stenokardiï naprugy i sertsevoï nedostatnosti buly identychnymy v ULNA i patsiientivgrupy kontroliu, u iakykh mala mistse komorbidnist' u vygliadi TsD. Ostanniĭ buv faktorom, shcho obtiazhuie perebig SSZta pryzvodyt' do bil'shoï poshyrenosti stenokardiï naprugy i sertsevoï nedostatnosti iak sered ULNA, tak i u ne-oprominenykh osib. Sered ULNA nakopychennia novykh vypadkiv zakhvoriuvannia na TsD vidbuvalosia bil'sh shvydkymytempamy v porivnianni z neoprominenym kontrolem, tomu ïkh seredniĭ vik na moment rozvytku TsD buv na 5 rokivmenshym, nizh v grupi kontroliu. |
| تواريخ الأحداث: | Date Created: 20181225 Date Completed: 20190906 Latest Revision: 20190906 |
| رمز التحديث: | 20221213 |
| DOI: | 10.33145/2304-8336-2018-23-246-253 |
| PMID: | 30582850 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2304-8336 |
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| DOI: | 10.33145/2304-8336-2018-23-246-253 |