دورية أكاديمية
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Ameliorative Effects of Helianthus Annuus Against Nephrotoxic, Cardiac, and Haematological Disorders in Alloxan-induced Hyperglycaemia in Albino Rats.

التفاصيل البيبلوغرافية
العنوان: Ameliorative Effects of Helianthus Annuus Against Nephrotoxic, Cardiac, and Haematological Disorders in Alloxan-induced Hyperglycaemia in Albino Rats.
المؤلفون: Onoja SO; Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Michael Okpara University of Agriculture Umudike, PMB 7267, Umuahia Abia State, Nigeria., Udem SC; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria Nsukka, Enugu State, Nigeria., Anaga AO; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria Nsukka, Enugu State, Nigeria.
المصدر: Journal of veterinary research [J Vet Res] 2018 Dec 10; Vol. 62 (3), pp. 371-377. Date of Electronic Publication: 2018 Dec 10 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sciendo Country of Publication: Poland NLM ID: 101696630 Publication Model: eCollection Cited Medium: Print ISSN: 2450-7393 (Print) Linking ISSN: 24507393 NLM ISO Abbreviation: J Vet Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: [Warsaw, Poland] : Sciendo
Original Publication: Pulawy : National Veterinary Research Institute, 2016-
مستخلص: Introduction: The study evaluated the ameliorative effects of Helianthus annuus leaf extract on nephrotoxicity, cardiac, and haematologic disorders in alloxan-induced hyperglycaemic rats.
Material and Methods: The cold maceration method with 80% methanol was used in the preparation of H . annuus extract. Thirty alloxan-induced hyperglycaemic rats were randomly assigned to five equal groups (A-E). Groups A and B received 5% tween-20 solution in water (5 mL/kg) and glibenclamide (2 mg/kg), respectively; while groups C, D, and E received 150, 300, and 600 mg/kg of the extract, respectively, per os once daily for 21 consecutive days. The levels of serum urea, creatinine, haematological indices, and histopathological changes in the kidneys and heart were evaluated 24 h after the last treatment on day 21.
Results: The extract and glibenclamide significantly (P < 0.05) reduced the levels of serum urea and urea : creatinine ratio in diabetic rats when compared with the vehicle treated group. The extract and glibenclamide also ameliorated haematological disorders and kidney and cardiac damage induced by alloxan.
Conclusion: H. annuus extract produced nephroprotective, cardioprotective, and haematoprotective effects and might prevent the advancement of diabetic complications such as diabetic nephropathy and cardiovascular diseases in diabetic patients.
Competing Interests: Conflict of Interests Statement: The authors declare no conflict of interests regarding the publication of this article.
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فهرسة مساهمة: Keywords: Helianthus annuus; cardio-; diabetes mellitus; haematoprotective properties; nephro-; rats
تواريخ الأحداث: Date Created: 20181226 Latest Revision: 20220330
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6295995
DOI: 10.2478/jvetres-2018-0053
PMID: 30584619
قاعدة البيانات: MEDLINE
الوصف
تدمد:2450-7393
DOI:10.2478/jvetres-2018-0053