دورية أكاديمية
Narrow band imaging and serology in the assessment of premalignant gastric pathology.
| العنوان: | Narrow band imaging and serology in the assessment of premalignant gastric pathology. |
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| المؤلفون: | White JR; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK., Sami SS; c 3 Mayo Clinic Division of Gastroenterology and Hepatology , Rochester , MN, USA., Reddiar D; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK., Mannath J; d 4 Department of Gastroenterology , University Hospitals Coventry and Warwickshire NHS Trust , Coventry , UK., Ortiz-Fernández-Sordo J; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK., Beg S; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK., Scott R; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK., Thiagarajan P; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK., Ahmad S; e 5 Sherwood Forest Hospitals NHS Foundation Trust, Kings Mill Hospital , Nottinghamshire , UK., Parra-Blanco A; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK., Kasi M; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK., Telakis E; f 6 Department of Gastroenterology , Hellenic Red Cross Hospital , Athens , Greece., Sultan AA; g 7 Research Institute for Primary Care and Health Sciences, Primary Care Sciences , Keele University , Staffordshire , UK., Davis J; h 8 Department of Pathology , Nottingham University Hospitals NHS Trust, Queen's Medical Centre Campus , Nottingham , UK., Figgins A; h 8 Department of Pathology , Nottingham University Hospitals NHS Trust, Queen's Medical Centre Campus , Nottingham , UK., Kaye P; h 8 Department of Pathology , Nottingham University Hospitals NHS Trust, Queen's Medical Centre Campus , Nottingham , UK., Robinson K; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK., Atherton JC; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK., Ragunath K; a 1 NIHR Nottingham Biomedical Research Centre , Nottingham University Hospitals NHS Trust and The University of Nottingham , Nottingham , UK.; b 2 Nottingham Digestive Diseases Centre , The University of Nottingham , Nottingham , UK. |
| المصدر: | Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2018 Dec; Vol. 53 (12), pp. 1611-1618. Date of Electronic Publication: 2019 Jan 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0060105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-7708 (Electronic) Linking ISSN: 00365521 NLM ISO Abbreviation: Scand J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Oslo : Universitetsforlager |
| مواضيع طبية MeSH: | Narrow Band Imaging*, Gastritis, Atrophic/*diagnostic imaging , Gastroscopy/*methods , Precancerous Conditions/*diagnostic imaging , Stomach Neoplasms/*diagnostic imaging, Adult ; Aged ; Aged, 80 and over ; Early Detection of Cancer ; Female ; Gastric Mucosa/pathology ; Gastritis, Atrophic/microbiology ; Gastritis, Atrophic/pathology ; Helicobacter Infections/complications ; Humans ; Male ; Middle Aged ; Observer Variation ; Precancerous Conditions/pathology ; Prospective Studies ; Sensitivity and Specificity ; Stomach Neoplasms/pathology ; United Kingdom ; Young Adult |
| مستخلص: | Background: Patient outcomes in gastric adenocarcinoma are poor due to late diagnosis. Detecting and treating at the premalignant stage has the potential to improve this. Helicobacter pylori is also a strong risk factor for this disease. Aims: Primary aims were to assess the diagnostic accuracy of magnified narrow band imaging (NBI-Z) endoscopy and serology in detecting normal mucosa, H. pylori gastritis and gastric atrophy. Secondary aims were to compare the diagnostic accuracies of two classification systems using both NBI-Z and white light endoscopy with magnification (WLE-Z) and evaluate the inter-observer agreement. Methods: Patients were prospectively recruited. Images of gastric mucosa were stored with histology and serum for IgG H. pylori and Pepsinogen (PG) I/II ELISAs. Blinded expert endoscopists agreed on mucosal pattern. Mucosal images and serological markers were compared with histology. Kappa statistics determined inter-observer variability for randomly allocated images among four experts and four non-experts. Results: 116 patients were prospectively recruited. Diagnostic accuracy of NBI-Z for determining normal gastric mucosa was 0.87(95%CI 0.82-0.92), H. pylori gastritis 0.65(95%CI 0.55-0.75) and gastric atrophy 0.88(95%CI 0.81-0.94). NBI-Z was superior to serology at detecting gastric atrophy: NBI-Z gastric atrophy 0.88(95%CI 0.81-0.94) vs PGI/II ratio < 3 0.74(95%CI 0.62-0.85) p<.0001. Overall NBI-Z was superior to WLE-Z in detecting disease using two validated classifications. Inter-observer agreement was 0.63(95%CI 0.51-0.73). Conclusions: NBI-Z accurately detects changes in the GI mucosa which currently depend on histology. NBI-Z is useful in the detection of precancerous conditions, potentially improving patient outcomes with early intervention to prevent gastric cancer. |
| معلومات مُعتمدة: | G0601170 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: gastritis; Endoscopy; gastric atrophy; intestinal metaplasia; narrow band imaging; serology; white light endoscopy |
| تواريخ الأحداث: | Date Created: 20190103 Date Completed: 20190528 Latest Revision: 20210109 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/00365521.2018.1542455 |
| PMID: | 30600732 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1502-7708 |
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| DOI: | 10.1080/00365521.2018.1542455 |