دورية أكاديمية
Neuroglia in the autistic brain: evidence from a preclinical model.
| العنوان: | Neuroglia in the autistic brain: evidence from a preclinical model. |
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| المؤلفون: | Bronzuoli MR; 1Department of Physiology and Pharmacology, 'Vittorio Erspamer' SAPIENZA University of Rome, 00185 Rome, Italy., Facchinetti R; 1Department of Physiology and Pharmacology, 'Vittorio Erspamer' SAPIENZA University of Rome, 00185 Rome, Italy., Ingrassia D; 1Department of Physiology and Pharmacology, 'Vittorio Erspamer' SAPIENZA University of Rome, 00185 Rome, Italy., Sarvadio M; 2Department of Science, Section of Biomedical Sciences and Technologies, University 'Roma Tre', 00154 Rome, Italy., Schiavi S; 2Department of Science, Section of Biomedical Sciences and Technologies, University 'Roma Tre', 00154 Rome, Italy., Steardo L; 1Department of Physiology and Pharmacology, 'Vittorio Erspamer' SAPIENZA University of Rome, 00185 Rome, Italy., Verkhratsky A; 3Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT UK.; 4Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; 5Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain., Trezza V; 2Department of Science, Section of Biomedical Sciences and Technologies, University 'Roma Tre', 00154 Rome, Italy., Scuderi C; 1Department of Physiology and Pharmacology, 'Vittorio Erspamer' SAPIENZA University of Rome, 00185 Rome, Italy. |
| المصدر: | Molecular autism [Mol Autism] 2018 Dec 27; Vol. 9, pp. 66. Date of Electronic Publication: 2018 Dec 27 (Print Publication: 2018). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101534222 Publication Model: eCollection Cited Medium: Internet ISSN: 2040-2392 (Electronic) NLM ISO Abbreviation: Mol Autism Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central |
| مواضيع طبية MeSH: | Autistic Disorder/*pathology , Brain/*pathology , Neuroglia/*pathology, Animals ; Autistic Disorder/etiology ; Autistic Disorder/physiopathology ; Brain/drug effects ; Female ; Male ; Neuroglia/drug effects ; Rats ; Rats, Wistar ; Stereotyped Behavior ; Valproic Acid/pharmacology ; Valproic Acid/toxicity ; Vocalization, Animal |
| مستخلص: | Background: Neuroglial cells that provide homeostatic support and form defence of the nervous system contribute to all neurological disorders. We analyzed three major types of neuroglia, astrocytes, oligodendrocytes, and microglia in the brains of an animal model of autism spectrum disorder, in which rats were exposed prenatally to antiepileptic and mood stabilizer drug valproic acid; this model being of acknowledged clinical relevance. Methods: We tested the autistic-like behaviors of valproic acid-prenatally exposed male rats by performing isolation-induced ultrasonic vocalizations, the three-chamber test, and the hole board test. To account for human infancy, adolescence, and adulthood, such tasks were performed at postnatal day 13, postnatal day 35, and postnatal day 90, respectively. After sacrifice, we examined gene and protein expression of specific markers of neuroglia in hippocampus, prefrontal cortex, and cerebellum, these brain regions being associated with autism spectrum disorder pathogenesis. Results: Infant offspring of VPA-exposed dams emitted less ultrasonic vocalizations when isolated from their mothers and siblings and, in adolescence and adulthood, they showed altered sociability in the three chamber test and increased stereotypic behavior in the hole board test. Molecular analyses indicate that prenatal valproic acid exposure affects all types of neuroglia, mainly causing transcriptional modifications. The most prominent changes occur in prefrontal cortex and in the hippocampus of autistic-like animals; these changes are particularly evident during infancy and adolescence, while they appear to be mitigated in adulthood. Conclusions: Neuroglial pathological phenotype in autism spectrum disorder rat model appears to be rather mild with little signs of widespread and chronic neuroinflammation. Competing Interests: All procedures involving animals were performed in accordance with the guidelines of the Italian Ministry of Health (D.L. 26/2014) and with the European Parliament directive 2010/63/EU.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
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| فهرسة مساهمة: | Keywords: Astrocyte; Autism spectrum disorder; Microglia; Oligodendrocyte; Valproic acid |
| المشرفين على المادة: | 614OI1Z5WI (Valproic Acid) |
| تواريخ الأحداث: | Date Created: 20190104 Date Completed: 20190128 Latest Revision: 20200309 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6307226 |
| DOI: | 10.1186/s13229-018-0254-0 |
| PMID: | 30603062 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2040-2392 |
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| DOI: | 10.1186/s13229-018-0254-0 |