دورية أكاديمية
The Role of Natural Medicines on Wound Healing: A Biomechanical, Histological, Biochemical and Molecular Study.
| العنوان: | The Role of Natural Medicines on Wound Healing: A Biomechanical, Histological, Biochemical and Molecular Study. |
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| المؤلفون: | Kotian S; Department of Anatomy, Center for Basic Sciences, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India., Bhat K; Dept. of Anatomy, RAK College of Medical Sciences, RAK Medical & Health Sciences University, Ras Al Khaimah, UAE., Pai S; Dept. of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India., Nayak J; Sri Dharmasthala Manjunatheshwara Ayurvedic College, Udyavara, Udupi, India., Souza A; Department of Anatomy, Center for Basic Sciences, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India., Gourisheti K; Dept. of Anatomy, RAK College of Medical Sciences, RAK Medical & Health Sciences University, Ras Al Khaimah, UAE., Padma D; Department of Anatomy, Center for Basic Sciences, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. |
| المصدر: | Ethiopian journal of health sciences [Ethiop J Health Sci] 2018 Nov; Vol. 28 (6), pp. 759-770. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Research and Publications Office of Jimma University Country of Publication: Ethiopia NLM ID: 101224773 Publication Model: Print Cited Medium: Internet ISSN: 2413-7170 (Electronic) Linking ISSN: 10291857 NLM ISO Abbreviation: Ethiop J Health Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Jimma, Ethiopia : Research and Publications Office of Jimma University |
| مواضيع طبية MeSH: | Ghee* , Glycyrrhiza* , Honey* , Nerium*, Biological Products/*pharmacology , Skin/*drug effects , Wound Healing/*drug effects, Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Apitherapy ; Biological Products/therapeutic use ; Female ; Inflammation/metabolism ; Inflammation/prevention & control ; Interleukin-1beta/blood ; Male ; Medicine, Traditional ; Myofibroblasts/metabolism ; Phytotherapy ; Plant Extracts/pharmacology ; Rats, Wistar |
| مستخلص: | Background: Traditional medicinal systems like Ayurveda and Indian folk medicine have used Honey, Ghee, Glycyrrhiza glabra, and Nerium indicum effectively for treating wounds. The known result of these medications is faster healing. However, the mechanism of actions at the tissue level, the biochemical and molecular mechanisms of healing is not well explored and documented. This present study was therefore designed to study the efficacy of these traditional medicines singly and in combinations on excision wounds in Wistar rats. Methods: At two different intervals (i.e., day 8 and day 16), biomechanical, histological and immunohistochemical (IHC) parameters were assessed at the wound site. IHC focused on the inflammatory rate by evaluating the level of cytokine, IL1β and the tissue remodeling by studying the activity of myofibroblasts. Results: Rapid epithelization, better remodeling, favorable inflammatory changes and an adequate myofibroblast activity at the wound site was observed in all the treated groups compared to control. Conclusion: This study is therefore useful in exploring the mechanism of action of these traditional medicines and providing valuable scientific evidence. |
| References: | Science. 1999 Jun 11;284(5421):1775. (PMID: 10391796) Curr Probl Surg. 2001 Feb;38(2):72-140. (PMID: 11452260) J Immunol. 2001 Nov 1;167(9):5316-20. (PMID: 11673547) Clin Plast Surg. 2003 Jan;30(1):1-12. (PMID: 12636211) Cytokine. 2003 Mar 7;21(5):242-7. (PMID: 12824009) Radiat Res. 2003 Nov;160(5):584-92. (PMID: 14565823) Ann Plast Surg. 1992 Oct;29(4):328-31. (PMID: 1466529) Int J Low Extrem Wounds. 2006 Mar;5(1):40-54. (PMID: 16543212) J Ethnopharmacol. 2006 Aug 11;107(1):38-47. (PMID: 16546334) Evid Based Complement Alternat Med. 2011;2011:134378. (PMID: 19252191) J Immunol. 2009 Oct 1;183(7):4705-14. (PMID: 19752225) J Tissue Viability. 2011 Nov;20(4):108-20. (PMID: 19995679) J Biomed Biotechnol. 2010;2010:709378. (PMID: 20300198) Evid Based Complement Alternat Med. 2013;2013:504537. (PMID: 23401714) Adv Wound Care (New Rochelle). 2014 Jul 1;3(7):445-464. (PMID: 25032064) Wounds. 2012 Apr;24(4):110-9. (PMID: 25876247) J Invest Dermatol. 2017 Mar;137(3):631-640. (PMID: 27777101) |
| فهرسة مساهمة: | Keywords: Ghee; Glycyrrhiza glabra; Honey; Nerium indicum; Wound Healing |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Biological Products) 0 (Ghee) 0 (Interleukin-1beta) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20190105 Date Completed: 20190415 Latest Revision: 20220331 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6308760 |
| DOI: | 10.4314/ejhs.v28i6.11 |
| PMID: | 30607093 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2413-7170 |
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| DOI: | 10.4314/ejhs.v28i6.11 |