دورية أكاديمية
Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii .
| العنوان: | Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii . |
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| المؤلفون: | Yakubu OF; Department of Biochemistry, College of Science and Technology, Covenant University, Canaan Land, Ota PMB 1023, Ogun State, Nigeria. omolara.yakubu@covenantuniversity.edu.ng.; State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences. #132, Lanhei Road, Heilongtan, Kunming 650201, China. omolara.yakubu@covenantuniversity.edu.ng., Adebayo AH; Department of Biochemistry, College of Science and Technology, Covenant University, Canaan Land, Ota PMB 1023, Ogun State, Nigeria. abiodun.adebayo@covenantuniversity.edu.ng., Dokunmu TM; Department of Biochemistry, College of Science and Technology, Covenant University, Canaan Land, Ota PMB 1023, Ogun State, Nigeria. titilope.dokunmu@covenantuniversity.edu.ng., Zhang YJ; State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences. #132, Lanhei Road, Heilongtan, Kunming 650201, China. zhangyj@mail.kib.ac.cn., Iweala EEJ; Department of Biochemistry, College of Science and Technology, Covenant University, Canaan Land, Ota PMB 1023, Ogun State, Nigeria. emeka.iweala@covenantuniversity.edu.ng. |
| المصدر: | Molecules (Basel, Switzerland) [Molecules] 2019 Jan 02; Vol. 24 (1). Date of Electronic Publication: 2019 Jan 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
| مواضيع طبية MeSH: | Antineoplastic Agents, Phytogenic/*pharmacology , Euphorbiaceae/*chemistry , Plant Extracts/*pharmacology, Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Gallic Acid/chemistry ; Glucosides/chemistry ; Humans ; Hydrolyzable Tannins/chemistry ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Extracts/isolation & purification ; Plant Leaves/chemistry ; Solvents/chemistry ; Structure-Activity Relationship |
| مستخلص: | This study was designed to explore the in vitro anticancer effects of the bioactive compounds isolated from Ricinodendron heudelotii on selected cancer cell lines. The leaves of the plant were extracted with ethanol and partitioned in sequence with petroleum ether, ethyl acetate, and n -butanol. The ethyl acetate fraction was phytochemically studied using thin layer chromatography (TLC) and column chromatography (CC). Structural elucidation of pure compounds obtained from the ethyl acetate fraction was done using mass spectra, ¹H-NMR, and 13 C-NMR analysis. The isolated compounds were subsequently screened using five different cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, SW-480, and normal lung epithelial cell line, BEAS-2B, to assess their cytotoxic effects. Nine compounds were isolated and structurally elucidated as gallic acid, gallic acid ethyl ester, corilagin, quercetin-3- O -rhamnoside, myricetin-3- O -rhamnoside, 1,4,6-tri- O -galloyl glucose, 3,4,6-tri- O -galloyl glucose, 1,2,6-tri- O -galloyl glucose, and 4,6-di- O -galloyl glucose. Corilagin exhibited the most cytotoxic activity with an IC |
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| معلومات مُعتمدة: | 3240287315 Organization for Women in Science for the Developing World |
| فهرسة مساهمة: | Keywords: Ricinodendron heudelotii; anticancer; chemoprevention |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Phytogenic) 0 (Glucosides) 0 (Hydrolyzable Tannins) 0 (Phytochemicals) 0 (Plant Extracts) 0 (Solvents) 13186-19-1 (6-O-galloylglucose) 62LOS9TW6D (corilagin) 632XD903SP (Gallic Acid) |
| تواريخ الأحداث: | Date Created: 20190106 Date Completed: 20191024 Latest Revision: 20200225 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6337108 |
| DOI: | 10.3390/molecules24010145 |
| PMID: | 30609707 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1420-3049 |
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| DOI: | 10.3390/molecules24010145 |