دورية أكاديمية
أعرض في EDS

Comprehensive evaluation of macroscopic and microscopic myocardial fibrosis by cardiac MR: intra-individual comparison of gadobutrol versus gadoterate meglumine.

التفاصيل البيبلوغرافية
العنوان: Comprehensive evaluation of macroscopic and microscopic myocardial fibrosis by cardiac MR: intra-individual comparison of gadobutrol versus gadoterate meglumine.
المؤلفون: Rahsepar AA; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., Suite 1600, Chicago, IL, 60611, USA. amir.rahsepar@northwestern.edu.; Department of Radiology, Yale New Haven Health, Bridgeport Hospital, Bridgeport, CT, USA. amir.rahsepar@northwestern.edu., Ghasemiesfe A; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., Suite 1600, Chicago, IL, 60611, USA.; Department of Radiology, Yale New Haven Health, Bridgeport Hospital, Bridgeport, CT, USA., Suwa K; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., Suite 1600, Chicago, IL, 60611, USA., Dolan RS; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., Suite 1600, Chicago, IL, 60611, USA., Shehata ML; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., Suite 1600, Chicago, IL, 60611, USA., Korell MJ; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., Suite 1600, Chicago, IL, 60611, USA., Naresh NK; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., Suite 1600, Chicago, IL, 60611, USA., Markl M; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., Suite 1600, Chicago, IL, 60611, USA., Collins JD; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., Suite 1600, Chicago, IL, 60611, USA.; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Carr JC; Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave., Suite 1600, Chicago, IL, 60611, USA.
المصدر: European radiology [Eur Radiol] 2019 Aug; Vol. 29 (8), pp. 4357-4367. Date of Electronic Publication: 2019 Jan 07.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer International, c1991-
مواضيع طبية MeSH: Cardiomyopathies/*diagnostic imaging , Magnetic Resonance Imaging/*methods , Myocardium/*pathology, Adult ; Aged ; Aged, 80 and over ; Cicatrix/diagnostic imaging ; Contrast Media ; Female ; Fibrosis ; Heart/diagnostic imaging ; Humans ; Male ; Meglumine ; Middle Aged ; Myocardial Infarction/diagnostic imaging ; Organometallic Compounds ; Prospective Studies ; Reproducibility of Results ; Young Adult
مستخلص: Purpose: Late gadolinium enhancement cardiac MR (LGE-CMR) and extracellular volume fraction (ECV-CMR) are widely used to evaluate macroscopic and microscopic myocardial fibrosis. Macrocyclic contrast media are increasingly used off-label for myocardial scar assessment, given the superior safety profile of these agents. We aimed to assess the performance of two macrocyclic contrast agents, gadoterate meglumine and gadobutrol, for the evaluation of myocardial scar.
Material and Methods: Forty subjects (61 ± 11 years, 67.5% men) who underwent LGE-CMR using gadobutrol were prospectively recruited for a research CMR scan using same-dose gadoterate meglumine (0.2 mmol/kg) at 1.5 T. Myocardial scar quantification was performed using a short-axis phase-sensitive inversion recovery (PSIR) Turbo-FLASH and steady-state free precession (SSFP) images. Pre- and post-contrast T1-mapping was employed to assess myocardial ECV. An intraclass correlation coefficient (ICC) was used to check for reliability between the two contrast agents.
Results: Using manual thresholding on PSIR Turbo-FLASH images, mean LGE scar percentage (LGE%) was 9.9 ± 9.7% and 9.4 ± 9.7% for gadobutrol and gadoterate meglumine, respectively (p > 0.05) (ICC: 0.99, 95% CI: 0.97-0.99). Using the PSIR SSFP technique and manual thresholding, LGE% averaged 7.5 ± 9.0% and 7.1 ± 8.6% for gadobutrol and gadoterate meglumine, respectively (p > 0.05) (ICC: 0.99, 95% CI: 0.98-0.99). Average ECV with gadobutrol and gadoterate meglumine were similar at 28.40 ± 4.88 and 28.46 ± 4.73 (p > 0.05) with a strong correlation (ICC: 0.98, 95% CI: 0.94-0.99).
Conclusion: We found LGE- and ECV-CMR values derived from gadoterate meglumine comparable to values derived from gadobutrol. Gadoterate meglumine has a comparable performance to gadobutrol in identifying LGE-derived myocardial scar both qualitatively and quantitatively.
Key Points: • Late gadolinium-enhancement cardiac MR (LGE-MR) and extracellular volume (ECV) fraction are widely used to evaluate macroscopic and microscopic myocardial fibrosis. • Macrocyclic contrast media are increasingly used off-label for myocardial scar assessment, given the presumed superior safety profile of these agents. • LGE- and ECV-CMR values derived from gadoterate meglumine are comparable to values derived from gadobutrol.
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فهرسة مساهمة: Keywords: Contrast agents; Heart; Magnetic resonance imaging; Scar
المشرفين على المادة: 0 (Contrast Media)
0 (Organometallic Compounds)
1BJ477IO2L (gadobutrol)
6HG8UB2MUY (Meglumine)
L0ND3981AG (gadoterate meglumine)
تواريخ الأحداث: Date Created: 20190109 Date Completed: 20191118 Latest Revision: 20200330
رمز التحديث: 20240628
DOI: 10.1007/s00330-018-5956-3
PMID: 30617490
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1084
DOI:10.1007/s00330-018-5956-3