دورية أكاديمية
Survival and Long-Term Biochemical Cure in Medullary Thyroid Carcinoma in Denmark 1997-2014: A Nationwide Study.
| العنوان: | Survival and Long-Term Biochemical Cure in Medullary Thyroid Carcinoma in Denmark 1997-2014: A Nationwide Study. |
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| المؤلفون: | Mathiesen JS; 1 Department of ORL-Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.; 2 Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Kroustrup JP; 3 Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark., Vestergaard P; 3 Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark.; 4 Steno Diabetes Center North Jutland, Gentofte, Denmark., Stochholm K; 5 Department of Internal Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark.; 6 Center for Rare Diseases, Aalborg University Hospital, Aalborg, Denmark., Poulsen PL; 5 Department of Internal Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark., Rasmussen ÅK; 7 Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark., Feldt-Rasmussen U; 7 Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark., Schytte S; 8 Department of ORL-Head & Neck Surgery and Aarhus University Hospital, Aarhus, Denmark., Londero SC; 8 Department of ORL-Head & Neck Surgery and Aarhus University Hospital, Aarhus, Denmark., Pedersen HB; 9 Department of ORL-Head & Neck Surgery, Aalborg University Hospital, Aalborg, Denmark., Hahn CH; 10 Department of ORL-Head & Neck Surgery, and Copenhagen University Hospital, Copenhagen, Denmark., Bentzen J; 11 Department of Oncology, Herlev Hospital, Herlev, Denmark., Möller S; 2 Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; 12 Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark., Gaustadnes M; 13 Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Rossing M; 14 Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark., Nielsen FC; 14 Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark., Brixen K; 2 Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Frederiksen AL; 2 Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; 15 Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Godballe C; 1 Department of ORL-Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark. |
| المصدر: | Thyroid : official journal of the American Thyroid Association [Thyroid] 2019 Mar; Vol. 29 (3), pp. 368-377. Date of Electronic Publication: 2019 Jan 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Publishers Country of Publication: United States NLM ID: 9104317 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9077 (Electronic) Linking ISSN: 10507256 NLM ISO Abbreviation: Thyroid Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Mary Ann Liebert Publishers, |
| مواضيع طبية MeSH: | Carcinoma, Medullary/*congenital , Multiple Endocrine Neoplasia Type 2a/*epidemiology , Multiple Endocrine Neoplasia Type 2a/*mortality , Thyroid Neoplasms/*epidemiology , Thyroid Neoplasms/*mortality, Adult ; Aged ; Carcinoma, Medullary/epidemiology ; Carcinoma, Medullary/mortality ; Carcinoma, Medullary/therapy ; Databases, Factual ; Denmark/epidemiology ; Disease-Free Survival ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Multiple Endocrine Neoplasia Type 2a/therapy ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Thyroid Neoplasms/therapy ; Treatment Outcome ; Young Adult |
| مستخلص: | Background: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the general population is poorly described. Data on the factors predicting long-term biochemical cure in MTC patients are nonexistent at a population level. A nationwide retrospective cohort study of MTC in Denmark from 1997 to 2014 was conducted, aiming to detect subgroups with survival similar to that of the general population and to identify prognostic factors for disease-specific survival and long-term biochemical cure. Methods: The study included 220 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. As a representative sample of the general population, a reference population matched 50:1 to the MTC cohort was used. Results: Patients diagnosed with hereditary MTC by screening (hazard ratio [HR] = 1.5 [confidence interval (CI) 0.5-4.3]), patients without regional metastases (HR = 1.4 [CI 0.9-2.3]), and patients with stage I (HR = 1.3 [CI 0.6-3.1]), stage II (HR = 1.1 [CI 0.6-2.3]), and III (HR = 1.3 [CI 0.4-4.2]) disease had an overall survival similar to the reference population. On multivariate analysis, the presence of distant metastases (HR = 12.3 [CI 6.0-25.0]) predicted worse disease-specific survival, while the absence of regional lymph node metastases (odds ratio = 40.1 [CI 12.0-133.7]) was the only independent prognostic factor for long-term biochemical cure. Conclusions: Patients with hereditary MTC diagnosed by screening, patients without regional metastases, and patients with stages I, II, and III disease may have similar survival as the general population. The presence of distant metastases predicted worse disease-specific survival, while the absence of regional metastases predicted long-term biochemical cure. |
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| فهرسة مساهمة: | Keywords: Denmark; biochemical cure; medullary thyroid carcinoma; nationwide; population-based; survival |
| SCR Disease Name: | Familial medullary thyroid carcinoma |
| تواريخ الأحداث: | Date Created: 20190109 Date Completed: 20200224 Latest Revision: 20220331 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6437622 |
| DOI: | 10.1089/thy.2018.0564 |
| PMID: | 30618340 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-9077 |
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| DOI: | 10.1089/thy.2018.0564 |