دورية أكاديمية
أعرض في EDS

Low Postseroconversion CD4 + T-cell Level Is Associated with Faster Disease Progression and Higher Viral Evolutionary Rate in HIV-2 Infection.

التفاصيل البيبلوغرافية
العنوان: Low Postseroconversion CD4 + T-cell Level Is Associated with Faster Disease Progression and Higher Viral Evolutionary Rate in HIV-2 Infection.
المؤلفون: Palm AA; Department of Laboratory Medicine, Lund University, Lund, Sweden., Lemey P; Department of Microbiology and Immunology, Rega Institute, KU Leuven-University of Leuven, Leuven, Belgium., Jansson M; Department of Laboratory Medicine, Lund University, Lund, Sweden., Månsson F; Department of Translational Medicine, Lund University, Lund, Sweden., Kvist A; Department of Clinical Sciences Lund, Lund University, Lund, Sweden., Szojka Z; Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary., Biague A; National Public Health Laboratory, Bissau, Guinea-Bissau., da Silva ZJ; National Public Health Laboratory, Bissau, Guinea-Bissau., Rowland-Jones SL; Nuffield Department of Medicine, NDM Research Building, University of Oxford, Oxford, United Kingdom., Norrgren H; Department of Clinical Sciences Lund, Lund University, Lund, Sweden., Esbjörnsson J; Department of Laboratory Medicine, Lund University, Lund, Sweden.; Nuffield Department of Medicine, NDM Research Building, University of Oxford, Oxford, United Kingdom., Medstrand P; Department of Translational Medicine, Lund University, Lund, Sweden patrik.medstrand@med.lu.se.
المصدر: MBio [mBio] 2019 Jan 08; Vol. 10 (1). Date of Electronic Publication: 2019 Jan 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Society for Microbiology
مواضيع طبية MeSH: CD4-Positive T-Lymphocytes/*immunology , HIV Infections/*immunology , HIV Infections/*pathology , HIV-2/*immunology, CD4 Lymphocyte Count ; Disease Progression ; Guinea-Bissau ; HIV Infections/virology ; Humans ; Longitudinal Studies ; Prospective Studies
مستخلص: A positive correlation between virus evolutionary rate and disease progression has been shown for human immunodeficiency virus type 1 (HIV-1) infection. Much less is known about HIV-2, the second causative agent of AIDS. We analyzed 528 HIV-2 env V1-C3 sequences generated from longitudinal plasma samples that were collected from 16 study participants during a median observation time of 7.9 years (interquartile range [IQR], 5.2 to 14.0 years). Study participants were classified as faster or slower disease progressors based on longitudinal CD4 + T-cell data. The HIV-2 evolutionary rate was significantly associated with CD4 + T-cell levels and was almost twice as high among the faster progressors as among the slower progressors. Higher evolutionary rates were accounted for by both synonymous and nonsynonymous nucleotide substitutions. Moreover, slow disease progression was associated with stronger positive selection on HIV-2/SIVsm (simian immunodeficiency virus infecting sooty mangabey) surface-exposed conserved residues. This study demonstrated a number of previously unknown characteristics linking HIV-2 disease progression with virus evolution. Some of these findings distinguish HIV-2 from HIV-1 and may contribute to the understanding of differences in pathogenesis. IMPORTANCE The relationship between HIV evolution and disease progression is fundamental to our understanding of HIV immune control and vaccine design. There are no clear definitions for faster and slower HIV-2 disease progression and for the relationship of the rate of progression with HIV-2 evolution. To address the hypothesis that viral evolution is correlated with disease progression in HIV-2 infection, we determined faster and slower disease progression based on follow-up data from a prospective cohort of police officers in Guinea-Bissau. The analysis showed that although the CD4 + T-cell level and the decline in the level were independently associated with progression to AIDS, only the CD4 + T-cell level or a combined CD4 + T-cell level/decline stratification was associated with the rate of HIV-2 evolution. The HIV-2 evolutionary rate was almost twice as high among the faster progressors as among the slower progressors. Importantly, this report defines previously unknown characteristics linking HIV-2 disease progression with virus evolution.
(Copyright © 2019 Palm et al.)
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فهرسة مساهمة: Keywords: disease progression; human immunodeficiency virus; viral evolution
تواريخ الأحداث: Date Created: 20190110 Date Completed: 20190410 Latest Revision: 20200309
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6325243
DOI: 10.1128/mBio.01245-18
PMID: 30622192
قاعدة البيانات: MEDLINE
الوصف
تدمد:2150-7511
DOI:10.1128/mBio.01245-18