دورية أكاديمية
The Human CD4 + T Cell Response against Mumps Virus Targets a Broadly Recognized Nucleoprotein Epitope.
العنوان: | The Human CD4 + T Cell Response against Mumps Virus Targets a Broadly Recognized Nucleoprotein Epitope. |
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المؤلفون: | de Wit J; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands jelle.de.wit@rivm.nl., Emmelot ME; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Poelen MCM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Lanfermeijer J; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Han WGH; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., van Els CACM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Kaaijk P; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. |
المصدر: | Journal of virology [J Virol] 2019 Mar 05; Vol. 93 (6). Date of Electronic Publication: 2019 Mar 05 (Print Publication: 2019). |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington Dc : American Society For Microbiology Original Publication: Baltimore, American Society for Microbiology. |
مواضيع طبية MeSH: | CD4-Positive T-Lymphocytes/*immunology , Epitopes, T-Lymphocyte/*immunology , Mumps/*immunology , Mumps virus/*immunology , Nucleoproteins/*immunology, HLA-DR Antigens/immunology ; Humans ; Interferon-gamma/immunology ; Leukocytes, Mononuclear/immunology |
مستخلص: | Mumps outbreaks among vaccinated young adults stress the need for a better understanding of mumps virus (MuV)-induced immunity. Antibody responses to MuV are well characterized, but studies on T cell responses are limited. We recently isolated a MuV-specific CD4 + T cell clone by stimulating peripheral blood mononuclear cells (PBMCs) from a mumps case with the viral nucleoprotein (MuV-N). In this study, we further explored the identity and relevance of the epitope recognized by the CD4 + T cell clone and ex vivo by T cells in a cohort of mumps cases. Using a two-dimensional matrix peptide pool of 15-mer peptides covering the complete MuV-N, we identified the epitope recognized by the T cell clone as MuV-N (Copyright © 2019 de Wit et al.) |
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فهرسة مساهمة: | Keywords: cytotoxicity; mumps G5 outbreak strain; mumps infection; mumps patients |
المشرفين على المادة: | 0 (Epitopes, T-Lymphocyte) 0 (HLA-DR Antigens) 0 (Nucleoproteins) 82115-62-6 (Interferon-gamma) |
تواريخ الأحداث: | Date Created: 20190111 Date Completed: 20191119 Latest Revision: 20200309 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC6401470 |
DOI: | 10.1128/JVI.01883-18 |
PMID: | 30626672 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1098-5514 |
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DOI: | 10.1128/JVI.01883-18 |