دورية أكاديمية
The Drosophila Ninein homologue Bsg25D cooperates with Ensconsin in myonuclear positioning.
| العنوان: | The Drosophila Ninein homologue Bsg25D cooperates with Ensconsin in myonuclear positioning. |
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| المؤلفون: | Rosen JN; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Azevedo M; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal., Soffar DB; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Boyko VP; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Molecular Cytology Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Brendel MB; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Molecular Cytology Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Schulman VK; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Cell and Developmental Biology, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY., Baylies MK; Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY m-baylies@ski.mskcc.org.; Cell and Developmental Biology, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY. |
| المصدر: | The Journal of cell biology [J Cell Biol] 2019 Feb 04; Vol. 218 (2), pp. 524-540. Date of Electronic Publication: 2019 Jan 09. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Rockefeller University Press |
| مواضيع طبية MeSH: | Cell Nucleus/*metabolism , Drosophila Proteins/*metabolism , Embryo, Nonmammalian/*metabolism , Microtubule-Associated Proteins/*metabolism , Microtubules/*metabolism , Muscle Fibers, Skeletal/*metabolism, Animals ; Cell Differentiation/physiology ; Cell Nucleus/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Microtubule-Associated Proteins/genetics ; Microtubules/genetics |
| مستخلص: | Skeletal muscle consists of multinucleated cells in which the myonuclei are evenly spaced throughout the cell. In Drosophila , this pattern is established in embryonic myotubes, where myonuclei move via microtubules (MTs) and the MT-associated protein Ensconsin (Ens)/MAP7, to achieve their distribution. Ens regulates multiple aspects of MT biology, but little is known about how Ens itself is regulated. We find that Ens physically interacts and colocalizes with Bsg25D, the Drosophila homologue of the centrosomal protein Ninein. Bsg25D loss enhances myonuclear positioning defects in embryos sensitized by partial Ens loss. Bsg25D overexpression causes severe positioning defects in immature myotubes and fully differentiated myofibers, where it forms ectopic MT organizing centers, disrupts perinuclear MT arrays, reduces muscle stiffness, and decreases larval crawling velocity. These studies define a novel relationship between Ens and Bsg25D. At endogenous levels, Bsg25D positively regulates Ens activity during myonuclear positioning, but excess Bsg25D disrupts Ens localization and MT organization, with disastrous consequences for myonuclear positioning and muscle function. (© 2019 Rosen et al.) |
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| معلومات مُعتمدة: | P30 CA008748 United States CA NCI NIH HHS; P40 OD010949 United States OD NIH HHS; R01 AR068128 United States AR NIAMS NIH HHS; R01 GM078318 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 0 (Bsg25D protein, Drosophila) 0 (Drosophila Proteins) 0 (Microtubule-Associated Proteins) |
| تواريخ الأحداث: | Date Created: 20190111 Date Completed: 20191210 Latest Revision: 20221207 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6363458 |
| DOI: | 10.1083/jcb.201808176 |
| PMID: | 30626718 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1540-8140 |
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| DOI: | 10.1083/jcb.201808176 |