دورية أكاديمية
Muscular-based and patient-reported outcomes differentially associate with circulating superoxide dismutases and cytokines in knee osteoarthritis.
| العنوان: | Muscular-based and patient-reported outcomes differentially associate with circulating superoxide dismutases and cytokines in knee osteoarthritis. |
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| المؤلفون: | Barker T; Precision Genomics, Intermountain Healthcare, Murray and St. George, UT 84107, USA; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: tyler.barker@imail.org., Rogers VE; The Orthopedic Specialty Hospital, Murray, UT 84107, USA., Henriksen VT; The Orthopedic Specialty Hospital, Murray, UT 84107, USA., Dixon BM; USANA Health Sciences, Inc., Salt Lake City, UT 84120, USA., Momberger NG; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA., Rasmussen GL; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; USANA Health Sciences, Inc., Salt Lake City, UT 84120, USA., Trawick RH; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA. |
| المصدر: | Cytokine [Cytokine] 2019 Mar; Vol. 115, pp. 45-49. Date of Electronic Publication: 2019 Jan 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001- > : Oxford : Elsevier Science Ltd. Original Publication: [Philadelphia, PA] : Saunders Scientific Publications, W.B. Saunders, [c1989- |
| مواضيع طبية MeSH: | Cytokines/*metabolism , Osteoarthritis, Knee/*metabolism , Quadriceps Muscle/*metabolism , Superoxide Dismutase/*metabolism, Biomarkers/metabolism ; Female ; Humans ; Male ; Middle Aged ; Muscle Strength/physiology ; Pain/metabolism ; Patient Reported Outcome Measures ; Torque |
| مستخلص: | Muscular (i.e., quadriceps) weakness contributes to disease progression and precedes the appearance of patient-reported symptoms, such as pain and perceived physical dysfunction, in knee osteoarthritis (OA). It is unknown, however, if muscular-based and patient-reported outcomes differentially associate with systemic biomarkers reflective of the local mediators in knee OA. The purpose of this study was to identify if muscular-based and patient-reported outcomes differentially associate with circulating superoxide dismutase (SOD) and cytokines in knee OA. Subjects (n = 29) with pain, muscular weakness, and radiographic evidence (Kellgren-Lawrence grade ≥2) of knee OA in the involved (INV) leg were included in this study. Serum Cu/Zn and Mn SOD and cytokine concentrations were measured in fasting blood samples. Pain and physical dysfunction were subjectively assessed and muscle strength (i.e., peak isometric force and torque, and peak isokinetic-concentric knee-extension and -flexion torques) was determined unilaterally in the INV and non-involved (NI) legs. Peak isometric and peak isokinetic-concentric knee-flexion torques in the INV leg correlated with serum Cu/Zn SOD (both p < 0.05). Peak isometric force and torque and peak isokinetic-concentric knee-extension and -flexion torques in the INV leg correlated with serum Mn SOD (all p < 0.05). Pain and dysfunction inversely associated with serum IL-1β, IL-4, IL-5, IL-12, IL-13, and/or IFN-γ (p < 0.05). Neither SOD associated with pain or dysfunction, and none of the cytokines associated with muscular-based outcomes. We conclude that common outcome measures used in the clinical evaluation of OA differentially associate with circulating SOD and cytokines. (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Clinical outcomes; Cytokines; Knee osteoarthritis; Superoxide dismutase |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Cytokines) EC 1.15.1.1 (Superoxide Dismutase) |
| تواريخ الأحداث: | Date Created: 20190112 Date Completed: 20200423 Latest Revision: 20200423 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.cyto.2018.11.034 |
| PMID: | 30634097 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-0023 |
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| DOI: | 10.1016/j.cyto.2018.11.034 |