دورية أكاديمية
أعرض في EDS

Diagnostic manifestations of total hemispheric glucose metabolism ratio in neuronal network diaschisis: diagnostic implications in Alzheimer's disease and mild cognitive impairment.

التفاصيل البيبلوغرافية
العنوان: Diagnostic manifestations of total hemispheric glucose metabolism ratio in neuronal network diaschisis: diagnostic implications in Alzheimer's disease and mild cognitive impairment.
المؤلفون: Segtnan EA; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Majdi A; Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Constantinescu C; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Grupe P; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark., Gerke O; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark., Dali HÍ; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Strøm OE; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Holm J; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark., Alavi A; Division of Nuclear Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sadigh-Eteghad S; Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Wermuth L; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.; Dementia Clinic, Department of Neurology, Odense University Hospital, Odense C, Denmark., Hildebrandt MG; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Gjedde A; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.; Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Neuroscience, Panum Institute, University of Copenhagen, Copenhagen, Denmark., Høilund-Carlsen PF; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. pfhc@rsyd.dk.; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. pfhc@rsyd.dk.
المصدر: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2019 May; Vol. 46 (5), pp. 1164-1174. Date of Electronic Publication: 2019 Jan 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer-Verlag Berlin, 2002-
مواضيع طبية MeSH: Alzheimer Disease/*diagnostic imaging , Alzheimer Disease/*physiopathology , Brain/*physiopathology , Cognitive Dysfunction/*diagnostic imaging , Cognitive Dysfunction/*physiopathology , Glucose/*metabolism , Nerve Net/*physiopathology, Aged ; Alzheimer Disease/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Cognitive Dysfunction/metabolism ; Female ; Humans ; Male ; Middle Aged ; Nerve Net/diagnostic imaging ; Nerve Net/metabolism ; Positron-Emission Tomography
مستخلص: Purpose: We tested the hypothesis that lateralized hemispheric glucose metabolism may have diagnostic implications in Alzheimer's disease (AD) and mild cognitive impairment (MCI).
Methods: We performed FDG-PET/CT in 23 patients (mean age 63.7 years, range 50-78, 17 females) diagnosed with AD (n = 15) or MCI (n = 8) during a six-month period in 2014. Ten neurologically healthy individuals (HIs) (mean age 62.5 years, range 43-75, 5 females) served as controls. A neuroimaging expert provided visual assessment of diaschisis. The total hemispheric glucose metabolism ratio (THGr) was calculated, and with area-under the curve of receiver operating characteristics (AUC-ROC) we generated a "Network Diaschisis Test (NDT)".
Results: The qualitative detection of cerebral (Ce) and cerebellar (Cb) diaschisis was 7/15 (47%), 0/8 (0%), and 0/10 (0%) in AD, MCI, and HI groups, respectively. Median cerebral THGr was 0.68 (range 0.43-0.99), 0.86 (range 0.64-0.98), and 0.95 (range 0.65-1.00) for AD, MCI, and HI groups, respectively (p = 0.04). Median cerebellar THGr was, respectively, 0.70 (range 0.18-0.98), 0.70 (range 0.48-0.81), and 0.84 (range 0.75-0.96) (p = 0.0138). A positive NDT yielded a positive predictive value of 100% for the presence of AD or MCI and a 86% negative predictive value for healthy brain. Moreover, the diagnostic manifestation of THGr between MCI and AD led to a positive predictive value of 100% for AD, but a negative predictive value of 42.9% for MCI.
Conclusion: Patients with AD or MCI had more pronounced diaschisis, lateralized hemispheric glucose metabolism and lower THGr compared to healthy controls. The NDT distinguished AD and MCI patients from HIs, and AD from MCI patients with a high positive predictive value and moderate and low negative predictive values. THGr can be a straightforward source of investigating neuronal network diaschisis in AD and MCI and in other cerebral diseases, across institutions.
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فهرسة مساهمة: Keywords: Alzheimer’s disease; Diaschisis; FDG-PET/CT; Mild cognitive impairment; Neuronal network
المشرفين على المادة: IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20190115 Date Completed: 20200525 Latest Revision: 20200525
رمز التحديث: 20221213
DOI: 10.1007/s00259-018-4248-0
PMID: 30637500
قاعدة البيانات: MEDLINE
الوصف
تدمد:1619-7089
DOI:10.1007/s00259-018-4248-0