دورية أكاديمية
Cutting Edge: ICOS-Deficient Regulatory T Cells Display Normal Induction of Il10 but Readily Downregulate Expression of Foxp3.
| العنوان: | Cutting Edge: ICOS-Deficient Regulatory T Cells Display Normal Induction of Il10 but Readily Downregulate Expression of Foxp3. |
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| المؤلفون: | Landuyt AE; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294; and., Klocke BJ; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294; and., Colvin TB; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294; and., Schoeb TR; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294., Maynard CL; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294; and craigmaynard@uabmc.edu. |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2019 Feb 15; Vol. 202 (4), pp. 1039-1044. Date of Electronic Publication: 2019 Jan 14. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Down-Regulation*/immunology, Forkhead Transcription Factors/*metabolism , Inducible T-Cell Co-Stimulator Protein/*metabolism , Interleukin-10/*metabolism , T-Lymphocytes, Regulatory/*metabolism, Animals ; Forkhead Transcription Factors/immunology ; Inducible T-Cell Co-Stimulator Protein/deficiency ; Inducible T-Cell Co-Stimulator Protein/immunology ; Inflammation/immunology ; Inflammation/metabolism ; Interleukin-10/immunology ; Mice ; Mice, Knockout ; Mice, Transgenic ; T-Lymphocytes, Regulatory/immunology |
| مستخلص: | The ICOS pathway has been implicated in the development and functions of regulatory T (Treg) cells, including those producing IL-10. Treg cell-derived IL-10 is indispensable for the establishment and maintenance of intestinal immune homeostasis. We examined the possible involvement of the ICOS pathway in the accumulation of murine colonic Foxp3- and/or IL-10-expressing cells. We show that ICOS deficiency does not impair induction of IL-10 by intestinal CD4 T cells but, instead, triggers substantial reductions in gut-resident and peripherally derived Foxp3 + Treg cells. ICOS deficiency is associated with reduced demethylation of Foxp3 CNS2 and enhanced loss of Foxp3. This instability significantly limits the ability of ICOS-deficient Treg cells to reverse ongoing inflammation. Collectively, our results identify a novel role for ICOS costimulation in imprinting the functional stability of Foxp3 that is required for the retention of full Treg cell function in the periphery. (Copyright © 2019 by The American Association of Immunologists, Inc.) |
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| معلومات مُعتمدة: | P30 AR048311 United States AR NIAMS NIH HHS; P30 CA013148 United States CA NCI NIH HHS; T32 AI007051 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Forkhead Transcription Factors) 0 (Foxp3 protein, mouse) 0 (IL10 protein, mouse) 0 (Icos protein, mouse) 0 (Inducible T-Cell Co-Stimulator Protein) 130068-27-8 (Interleukin-10) |
| تواريخ الأحداث: | Date Created: 20190116 Date Completed: 20191024 Latest Revision: 20200309 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6363853 |
| DOI: | 10.4049/jimmunol.1801266 |
| PMID: | 30642977 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-6606 |
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| DOI: | 10.4049/jimmunol.1801266 |