دورية أكاديمية
The role of matrix metalloproteinase-9 in negative reinforcement learning and plasticity in alcohol dependence.
العنوان: | The role of matrix metalloproteinase-9 in negative reinforcement learning and plasticity in alcohol dependence. |
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المؤلفون: | Go BS; Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Alcohol and Drug Abuse Research Program, Translational Addictions Research Center, Washington State University, Pullman, Washington, USA., Sirohi S; Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Alcohol and Drug Abuse Research Program, Translational Addictions Research Center, Washington State University, Pullman, Washington, USA., Walker BM; Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Alcohol and Drug Abuse Research Program, Translational Addictions Research Center, Washington State University, Pullman, Washington, USA. |
المصدر: | Addiction biology [Addict Biol] 2020 Mar; Vol. 25 (2), pp. e12715. Date of Electronic Publication: 2019 Jan 16. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9604935 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1369-1600 (Electronic) Linking ISSN: 13556215 NLM ISO Abbreviation: Addict Biol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Hoboken, NJ : Wiley-Blackwell Original Publication: Abingdon, Oxfordshire, UK ; Cambridge, MA : Carfax, c1996- |
مواضيع طبية MeSH: | Reinforcement, Psychology*, Alcoholism/*physiopathology , Brain/*metabolism , Brain/*physiopathology , Matrix Metalloproteinase 9/*metabolism , Neuronal Plasticity/*drug effects, Alcoholism/metabolism ; Animals ; Brain/drug effects ; Disease Models, Animal ; Learning ; Male ; Rats ; Rats, Wistar ; Self Administration |
مستخلص: | A role for matrix metalloproteinases (MMPs) in plasticity-dependent learning has been established. MMPs degrade the extracellular matrix (ECM) when synaptic reorganization is warranted. Previously, we showed that escalation of alcohol self-administration is a learned plasticity-dependent process that requires an intact MMP system. To identify the MMP subtypes within specific brain regions that are associated with plasticity underlying the negative reinforcing effects of alcohol (as measured by escalated alcohol self-administration) during acute withdrawal in alcohol dependence, male Wistar rats were trained to self-administer alcohol in an operant paradigm, subjected to one month of intermittent alcohol vapor exposure to induce alcohol dependence and then allowed to self-administer alcohol during repeated acute withdrawal self-administration sessions. Subsequently, rat brains were extracted after initial or stable escalated alcohol self-administration phases of acute withdrawal and analyzed by immunoblot to detect MMP-2, -3, and -9 levels in the anterior cingulate cortex (ACC), bed nucleus of the stria terminalis, central amygdala (CeA), hippocampus, and nucleus accumbens (NAc). The results showed that MMP-9 expression in the CeA and NAc of alcohol-dependent rats was increased, however, MMP-9 expression in the ACC was decreased during negative reinforcement learning. Subsequently, the importance of plasticity mediated by MMP-9 in escalated alcohol self-administration during acute withdrawal was functionally assessed through site-specific intra-CeA MMP-9 inhibition during repeated acute withdrawal self-administration sessions. MMP-9 inhibition prevented acute withdrawal-induced escalation of alcohol self-administration in a manner that was not confounded by locomotor effects or a permanent inability to learn about the negative reinforcing effects of alcohol. (© 2019 Society for the Study of Addiction.) |
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معلومات مُعتمدة: | R01 AA020394 United States AA NIAAA NIH HHS; R01AA020394 United States AA NIAAA NIH HHS |
فهرسة مساهمة: | Keywords: alcohol dependence; matrix metalloproteinase; negative reinforcement |
المشرفين على المادة: | EC 3.4.24.35 (Matrix Metalloproteinase 9) |
تواريخ الأحداث: | Date Created: 20190117 Date Completed: 20210216 Latest Revision: 20210216 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC6635097 |
DOI: | 10.1111/adb.12715 |
PMID: | 30648329 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1369-1600 |
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DOI: | 10.1111/adb.12715 |