دورية أكاديمية
أعرض في EDS

The role of matrix metalloproteinase-9 in negative reinforcement learning and plasticity in alcohol dependence.

التفاصيل البيبلوغرافية
العنوان: The role of matrix metalloproteinase-9 in negative reinforcement learning and plasticity in alcohol dependence.
المؤلفون: Go BS; Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Alcohol and Drug Abuse Research Program, Translational Addictions Research Center, Washington State University, Pullman, Washington, USA., Sirohi S; Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Alcohol and Drug Abuse Research Program, Translational Addictions Research Center, Washington State University, Pullman, Washington, USA., Walker BM; Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Alcohol and Drug Abuse Research Program, Translational Addictions Research Center, Washington State University, Pullman, Washington, USA.
المصدر: Addiction biology [Addict Biol] 2020 Mar; Vol. 25 (2), pp. e12715. Date of Electronic Publication: 2019 Jan 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9604935 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1369-1600 (Electronic) Linking ISSN: 13556215 NLM ISO Abbreviation: Addict Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Hoboken, NJ : Wiley-Blackwell
Original Publication: Abingdon, Oxfordshire, UK ; Cambridge, MA : Carfax, c1996-
مواضيع طبية MeSH: Reinforcement, Psychology*, Alcoholism/*physiopathology , Brain/*metabolism , Brain/*physiopathology , Matrix Metalloproteinase 9/*metabolism , Neuronal Plasticity/*drug effects, Alcoholism/metabolism ; Animals ; Brain/drug effects ; Disease Models, Animal ; Learning ; Male ; Rats ; Rats, Wistar ; Self Administration
مستخلص: A role for matrix metalloproteinases (MMPs) in plasticity-dependent learning has been established. MMPs degrade the extracellular matrix (ECM) when synaptic reorganization is warranted. Previously, we showed that escalation of alcohol self-administration is a learned plasticity-dependent process that requires an intact MMP system. To identify the MMP subtypes within specific brain regions that are associated with plasticity underlying the negative reinforcing effects of alcohol (as measured by escalated alcohol self-administration) during acute withdrawal in alcohol dependence, male Wistar rats were trained to self-administer alcohol in an operant paradigm, subjected to one month of intermittent alcohol vapor exposure to induce alcohol dependence and then allowed to self-administer alcohol during repeated acute withdrawal self-administration sessions. Subsequently, rat brains were extracted after initial or stable escalated alcohol self-administration phases of acute withdrawal and analyzed by immunoblot to detect MMP-2, -3, and -9 levels in the anterior cingulate cortex (ACC), bed nucleus of the stria terminalis, central amygdala (CeA), hippocampus, and nucleus accumbens (NAc). The results showed that MMP-9 expression in the CeA and NAc of alcohol-dependent rats was increased, however, MMP-9 expression in the ACC was decreased during negative reinforcement learning. Subsequently, the importance of plasticity mediated by MMP-9 in escalated alcohol self-administration during acute withdrawal was functionally assessed through site-specific intra-CeA MMP-9 inhibition during repeated acute withdrawal self-administration sessions. MMP-9 inhibition prevented acute withdrawal-induced escalation of alcohol self-administration in a manner that was not confounded by locomotor effects or a permanent inability to learn about the negative reinforcing effects of alcohol.
(© 2019 Society for the Study of Addiction.)
References: Neuropharmacology. 2018 Sep 15;140:162-173. (PMID: 30075159)
Neuroscience. 1988 Oct;27(1):1-39. (PMID: 3059226)
Nat Rev Neurosci. 2012 Nov;13(11):743-57. (PMID: 23047773)
Learn Mem. 2007 Sep 25;14(10):655-64. (PMID: 17909100)
Psychopharmacology (Berl). 2012 Sep;223(1):75-88. (PMID: 22461104)
PLoS One. 2007 Nov 14;2(11):e1187. (PMID: 18000554)
Neuropsychopharmacology. 2010 Jan;35(1):217-38. (PMID: 19710631)
Brain Res. 2003 Feb 14;963(1-2):252-61. (PMID: 12560131)
Neurobiol Learn Mem. 2011 Sep;96(2):199-206. (PMID: 21530666)
Neuropharmacology. 2017 Aug 1;122:85-99. (PMID: 28108359)
Brain Res. 2010 Apr 23;1327:103-6. (PMID: 20197064)
Curr Top Behav Neurosci. 2013;13:3-30. (PMID: 21744309)
Annu Rev Cell Dev Biol. 2001;17:463-516. (PMID: 11687497)
Front Mol Neurosci. 2012 Sep 27;5:95. (PMID: 23060746)
J Neuroimmunol. 2005 Feb;159(1-2):146-54. (PMID: 15652414)
Cancer Res. 1995 Jun 15;55(12):2548-55. (PMID: 7780967)
Biochem Biophys Res Commun. 2003 Aug 22;308(2):386-95. (PMID: 12901881)
Science. 1967 Aug 4;157(3788):552-4. (PMID: 6028919)
Neuropsychopharmacology. 1998 Mar;18(3):135-74. (PMID: 9471114)
J Neurochem. 2007 Mar;100(6):1579-88. (PMID: 17348864)
Nat Neurosci. 2004 Apr;7(4):398-403. (PMID: 15004562)
Brain Res. 2015 Dec 2;1628(Pt A):29-39. (PMID: 25838241)
Biol Psychiatry. 2017 Jun 1;81(11):907-917. (PMID: 28190519)
Biol Psychiatry. 2007 Aug 15;62(4):359-62. (PMID: 17210139)
Alcohol. 2012 Jun;46(4):339-48. (PMID: 22459874)
Biochem Res Int. 2012;2012:789083. (PMID: 22567285)
Alcohol Clin Exp Res. 2004 Nov;28(11):1676-82. (PMID: 15547454)
Neuropsychopharmacology. 2016 Jan;41(2):560-7. (PMID: 26105136)
Neurobiol Learn Mem. 2008 May;89(4):441-7. (PMID: 18065245)
Alcohol Clin Exp Res. 2007 Jan;31(1):11-8. (PMID: 17207096)
Synapse. 2008 Dec;62(12):886-9. (PMID: 18792988)
Curr Opin Neurobiol. 2011 Apr;21(2):353-9. (PMID: 21277196)
J Biol Chem. 1992 Feb 25;267(6):3581-4. (PMID: 1371271)
Neuropsychopharmacology. 2000 Jun;22(6):581-94. (PMID: 10788758)
Ann N Y Acad Sci. 1992 Jun 28;654:171-91. (PMID: 1632582)
Biol Psychiatry. 2014 May 15;75(10):774-82. (PMID: 23611261)
Neuropsychopharmacology. 2001 Feb;24(2):97-129. (PMID: 11120394)
J Neurosci. 2013 Sep 4;33(36):14591-600. (PMID: 24005309)
Behav Brain Res. 2011 Jun 1;219(2):358-62. (PMID: 21219940)
J Neurochem. 2006 Mar;96(5):1227-41. (PMID: 16464240)
Neuropharmacology. 2017 Aug 1;122:100-106. (PMID: 28351600)
Nat Neurosci. 2014 Dec;17(12):1655-7. (PMID: 25326689)
Neuropharmacology. 2011 Jul-Aug;61(1-2):35-42. (PMID: 21338616)
Alcohol Clin Exp Res. 2009 Dec;33(12):2113-23. (PMID: 19740131)
Front Cell Neurosci. 2015 Mar 11;9:73. (PMID: 25814930)
Bioorg Med Chem Lett. 2001 Aug 20;11(16):2189-92. (PMID: 11514167)
Alcohol Clin Exp Res. 2003 Feb;27(2):232-43. (PMID: 12605072)
Neural Plast. 2009;2009:579382. (PMID: 20169175)
J Neurochem. 2007 Sep;102(5):1548-1560. (PMID: 17472698)
Nat Neurosci. 2013 Nov;16(11):1644-51. (PMID: 24077564)
معلومات مُعتمدة: R01 AA020394 United States AA NIAAA NIH HHS; R01AA020394 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: alcohol dependence; matrix metalloproteinase; negative reinforcement
المشرفين على المادة: EC 3.4.24.35 (Matrix Metalloproteinase 9)
تواريخ الأحداث: Date Created: 20190117 Date Completed: 20210216 Latest Revision: 20210216
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6635097
DOI: 10.1111/adb.12715
PMID: 30648329
قاعدة البيانات: MEDLINE
الوصف
تدمد:1369-1600
DOI:10.1111/adb.12715