دورية أكاديمية
Bacteremia in kidney transplant recipients: Burden, causes, and consequences.
| العنوان: | Bacteremia in kidney transplant recipients: Burden, causes, and consequences. |
|---|---|
| المؤلفون: | Brar S; Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.; Department of Medicine, Division of Nephrology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada., Wang Y; Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada., Cannitelli A; Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada., Lambadaris M; Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada., Li Y; Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada., Famure O; Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.; Department of Medicine, Division of Nephrology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada., Husain S; Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.; Department of Medicine, Division of Infectious Diseases, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada., Kim SJ; Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.; Department of Medicine, Division of Nephrology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. |
| المصدر: | Clinical transplantation [Clin Transplant] 2019 Mar; Vol. 33 (3), pp. e13479. Date of Electronic Publication: 2019 Feb 08. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8710240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0012 (Electronic) Linking ISSN: 09020063 NLM ISO Abbreviation: Clin Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Copenhagen : Munksgaard, |
| مواضيع طبية MeSH: | Postoperative Complications*, Bacteremia/*epidemiology , Bacteria/*isolation & purification , Graft Rejection/*epidemiology , Kidney Failure, Chronic/*surgery , Kidney Transplantation/*adverse effects, Bacteremia/etiology ; Bacteremia/pathology ; Bacteria/classification ; Canada/epidemiology ; Cohort Studies ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Graft Rejection/etiology ; Graft Rejection/pathology ; Graft Survival ; Humans ; Incidence ; Kidney Function Tests ; Male ; Middle Aged ; Prognosis ; Registries ; Risk Assessment ; Risk Factors |
| مستخلص: | Bacteremia is an important complication after kidney transplantation. We examined bacteremia and its outcomes in a large cohort of kidney transplant recipients. Kidney transplants from 1-Jul-2004 to 1-Dec-2014 at the Toronto General Hospital were eligible for study inclusion. Bacteremia was defined as two blood culture positives for common skin contaminants or one blood culture positive for other organisms. The cumulative incidence of first bacteremia was estimated using the Kaplan-Meier method, and risk factors were examined in a Cox proportional hazards model. The risk of graft failure or death was assessed in a time-dependent Cox model. Over follow-up, 154 of 1333 patients had at least one bacteremia episode. The cumulative incidence of first bacteremia was 6.8% (6 months) and 11.9% (5 years). Risk factors included recipient diabetes mellitus, time on dialysis, dialysis modality, delayed graft function, donor age, and donor eGFR. Bacteremia increased the risk of total graft failure (hazard ratio 2.11 [95% CI: 1.50, 2.96]), death-censored graft failure (1.73 [0.99, 3.02]), and death with graft function (2.52 [1.63, 3.89]). In conclusion, bacteremia is common after kidney transplantation and impacts both graft and patient survival. Identifying high-risk patients for targeted preventive strategies may reduce the burden and adverse consequences of this important complication. (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
| فهرسة مساهمة: | Keywords: Kidney transplantation; bacteremia; incidence; outcomes; risk factors |
| تواريخ الأحداث: | Date Created: 20190117 Date Completed: 20200501 Latest Revision: 20200501 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/ctr.13479 |
| PMID: | 30650217 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1399-0012 |
|---|---|
| DOI: | 10.1111/ctr.13479 |