دورية أكاديمية
Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances.
| العنوان: | Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances. |
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| المؤلفون: | Hassan HAFM; Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, London SE1 9NH, United Kingdom., Diebold SS; Biotherapeutics Division, National Institute for Biological Standards and Control (NIBSC), Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom., Smyth LA; School of Health, Sport and Biosciences, University of East London, Stratford Campus, Water Lane, London E15 4LZ, United Kingdom., Walters AA; Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, London SE1 9NH, United Kingdom., Lombardi G; School of Immunology and Microbial Sciences, Guy's Hospital, King's College London, London SE1 9RT, United Kingdom., Al-Jamal KT; Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, London SE1 9NH, United Kingdom. Electronic address: Khuloud.al-jamal@kcl.ac.uk. |
| المصدر: | Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2019 Mar 10; Vol. 297, pp. 79-90. Date of Electronic Publication: 2019 Jan 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, 1984- |
| مواضيع طبية MeSH: | Adjuvants, Immunologic/*chemistry , Antineoplastic Agents/*chemistry , Cancer Vaccines/*chemistry , Drug Carriers/*chemistry , Nanotubes, Carbon/*chemistry , Neoplasms/*therapy, Adjuvants, Immunologic/pharmacology ; Animals ; Antineoplastic Agents/pharmacology ; Biocompatible Materials/chemistry ; Cell Line, Tumor ; Cell Membrane Permeability ; Drug Liberation ; Humans ; Molecular Targeted Therapy ; Neoplasms/prevention & control ; Surface Properties |
| مستخلص: | Tumour-specific, immuno-based therapeutic interventions can be considered as safe and effective approaches for cancer therapy. Exploitation of nano-vaccinology to intensify the cancer vaccine potency may overcome the need for administration of high vaccine doses or additional adjuvants and therefore could be a more efficient approach. Carbon nanotube (CNT) can be described as carbon sheet(s) rolled up into a cylinder that is nanometers wide and nanometers to micrometers long. Stemming from the observed capacities of CNTs to enter various types of cells via diversified mechanisms utilising energy-dependent and/or passive routes of cell uptake, the use of CNTs for the delivery of therapeutic agents has drawn increasing interests over the last decade. Here we review the previous studies that demonstrated the possible benefits of these cylindrical nano-vectors as cancer vaccine delivery systems as well as the obstacles their clinical application is facing. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| معلومات مُعتمدة: | BB/J008656/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council |
| فهرسة مساهمة: | Keywords: Antigen presenting cells; Cancer immunotherapy; Carbon nanotube; Nanomedicine; Vaccine delivery |
| المشرفين على المادة: | 0 (Adjuvants, Immunologic) 0 (Antineoplastic Agents) 0 (Biocompatible Materials) 0 (Cancer Vaccines) 0 (Drug Carriers) 0 (Nanotubes, Carbon) |
| تواريخ الأحداث: | Date Created: 20190120 Date Completed: 20200605 Latest Revision: 20240724 |
| رمز التحديث: | 20240725 |
| DOI: | 10.1016/j.jconrel.2019.01.017 |
| PMID: | 30659906 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4995 |
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| DOI: | 10.1016/j.jconrel.2019.01.017 |