دورية أكاديمية
أعرض في EDS

Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.

التفاصيل البيبلوغرافية
العنوان: Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.
المؤلفون: Zinter MS; Division of Critical Care, Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA., Spicer AC; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA., Liu KD; Departments of Anesthesia and Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA., Orwoll BE; Division of Critical Care, Department of Pediatrics, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, OR., Alkhouli MF; Division of Critical Care, Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA., Brakeman PR; Department of Pediatrics, Division of Nephrology, University of California, San Francisco Benioff Children's Hospital, San Francisco, CA., Calfee CS; Departments of Anesthesia and Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA., Matthay MA; Departments of Anesthesia and Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA., Sapru A; Division of Critical Care, Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.; Department of Pediatrics, Division of Critical Care, Mattel Children's Hospital, University of California, Los Angeles, CA.
المصدر: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [Pediatr Crit Care Med] 2019 Apr; Vol. 20 (4), pp. 323-331.
نوع المنشور: Journal Article; Observational Study; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100954653 Publication Model: Print Cited Medium: Internet ISSN: 1529-7535 (Print) Linking ISSN: 15297535 NLM ISO Abbreviation: Pediatr Crit Care Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Baltimore, MD : Lippincott Williams & Wilkins, c2000-
مواضيع طبية MeSH: Acute Kidney Injury/*mortality , Intensive Care Units, Pediatric/*statistics & numerical data , Respiratory Distress Syndrome/*mortality , Water-Electrolyte Balance/*physiology, Acute Kidney Injury/epidemiology ; Adolescent ; Age Factors ; Biomarkers ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Interleukin-6/blood ; Male ; Prospective Studies ; Racial Groups ; Respiration, Artificial/statistics & numerical data ; Respiratory Distress Syndrome/epidemiology ; Risk Factors ; Severity of Illness Index ; Sex Factors
مستخلص: Objectives: As acute kidney injury and elevated cumulative fluid balance commonly co-occur in pediatric acute respiratory distress syndrome, we aimed to identify risk factors for their development and evaluate their independent relationships with mortality. We hypothesized that acute kidney injury and elevated cumulative fluid balance would be associated with markers of inflammation and that children with elevated cumulative fluid balance and concomitant acute kidney injury would have worse outcomes than other children.
Design: Prospective observational study using the pediatric Risk, Injury, Failure, Loss, End-Stage acute kidney injury classification.
Setting: Five academic PICUs.
Patients: Two-hundred sixty patients 1 month to 18 years old meeting the Berlin definition of acute respiratory distress syndrome between 2008 and 2014.
Interventions: None.
Measurements and Results: PICU mortality was 13% (34/260). Relative to survivors, nonsurvivors had greater cumulative fluid balance on day 3 of acute respiratory distress syndrome (+90.1 mL/kg; interquartile range 26.6-161.7 vs +44.9 mL/kg; interquartile range 10.0-111.3; p = 0.008) and also had higher prevalence of acute kidney injury on day 3 of acute respiratory distress syndrome (50% vs 23%; p = 0.001). On stratified analysis, greater cumulative fluid balance on day 3 of acute respiratory distress syndrome was associated with mortality among patients with concomitant acute kidney injury (+111.5 mL/kg for nonsurvivors; interquartile range 82.6-236.8 vs +58.5 mL/kg for survivors; interquartile range 0.9-176.2; p = 0.041) but not among patients without acute kidney injury (p = 0.308). The presence of acute kidney injury on acute respiratory distress syndrome day 3 was associated with mortality among patients with positive cumulative fluid balance (29.1% vs 10.4% mortality; p = 0.001) but not among patients with even or negative cumulative fluid balance (p = 0.430). Day 1 plasma interleukin-6 levels were associated with the development of day 3 positive cumulative fluid balance, day 3 acute kidney injury, and PICU mortality and the association between elevated day 1 interleukin-6 and PICU mortality was partially mediated by the interval development of day 3 positive cumulative fluid balance and day 3 acute kidney injury (p < 0.001).
Conclusions: In pediatric acute respiratory distress syndrome, elevated cumulative fluid balance on day 3 of acute respiratory distress syndrome is associated with mortality specifically in patients with concomitant acute kidney injury. Plasma interleukin-6 levels are associated with the development of positive cumulative fluid balance and acute kidney injury, suggesting a potential mechanism by which inflammation might predispose to mortality.
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معلومات مُعتمدة: K23 HL085526 United States HL NHLBI NIH HHS; R01 HL114484 United States HL NHLBI NIH HHS; K12 HD000850 United States HD NICHD NIH HHS; R01 DK098233 United States DK NIDDK NIH HHS; R37 HL051856 United States HL NHLBI NIH HHS; K24 DK113381 United States DK NIDDK NIH HHS; T32 HD049303 United States HD NICHD NIH HHS; R01 HL110969 United States HL NHLBI NIH HHS; R01 DK101507 United States DK NIDDK NIH HHS; U01 HL108713 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (Biomarkers)
0 (Interleukin-6)
تواريخ الأحداث: Date Created: 20190124 Date Completed: 20200511 Latest Revision: 20211204
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6454886
DOI: 10.1097/PCC.0000000000001845
PMID: 30672838
قاعدة البيانات: MEDLINE
الوصف
تدمد:1529-7535
DOI:10.1097/PCC.0000000000001845