دورية أكاديمية
Carbonic Anhydrase Inhibitors of Different Structures Dilate Pre-Contracted Porcine Retinal Arteries.
| العنوان: | Carbonic Anhydrase Inhibitors of Different Structures Dilate Pre-Contracted Porcine Retinal Arteries. |
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| المؤلفون: | Eysteinsson T; Department of Physiology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland. thoreys@hi.is., Gudmundsdottir H; Department of Physiology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Hardarson AO; Department of Physiology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Berrino E; NEUROFARBA Department, University of Florence, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy., Selleri S; NEUROFARBA Department, University of Florence, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy., Supuran CT; NEUROFARBA Department, University of Florence, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy., Carta F; NEUROFARBA Department, University of Florence, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2019 Jan 22; Vol. 20 (3). Date of Electronic Publication: 2019 Jan 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مواضيع طبية MeSH: | Carbonic Anhydrase Inhibitors/*pharmacology , Carbonic Anhydrases/*metabolism , Muscle, Smooth, Vascular/*drug effects , Retinal Artery/*drug effects , Vasodilation/*drug effects, Acetazolamide/chemistry ; Acetazolamide/pharmacology ; Animals ; Benzolamide/chemistry ; Benzolamide/pharmacology ; Carbonic Anhydrase Inhibitors/chemistry ; Sulfonamides/chemistry ; Sulfonamides/pharmacology ; Swine ; Thiophenes/chemistry ; Thiophenes/pharmacology |
| مستخلص: | Carbonic anhydrase inhibitors (CAIs), such as dorzolamide (DZA), are used as anti-glaucoma drugs to lower intraocular pressure, but it has been found that some of these drugs act as vasodilators of retinal arteries. The exact mechanism behind the vasodilatory effect is not yet clear. Here we have addressed the issue by using small vessel myography to examine the effect of CAIs of the sulfonamide and coumarin type on the wall tension in isolated segments of porcine retinal arteries. Vessels were pre-contracted by the prostaglandin analog U-46619, and CAIs with varying affinity for five different carbonic anhydrase (CA) isoenzymes found in human tissue tested. We found that all compounds tested cause a vasodilation of pre-contracted retinal arteries, but with varying efficacy, as indicated by the calculated mean EC Competing Interests: The authors declare no conflict of interest. |
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| فهرسة مساهمة: | Keywords: carbonic anhydrase; vascular tone; vasodilation |
| المشرفين على المادة: | 0 (Carbonic Anhydrase Inhibitors) 0 (Sulfonamides) 0 (Thiophenes) 9JDX055TW1 (dorzolamide) EC 4.2.1.1 (Carbonic Anhydrases) FC5AAH89R5 (Benzolamide) O3FX965V0I (Acetazolamide) |
| تواريخ الأحداث: | Date Created: 20190126 Date Completed: 20190513 Latest Revision: 20231006 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6387369 |
| DOI: | 10.3390/ijms20030467 |
| PMID: | 30678227 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1422-0067 |
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| DOI: | 10.3390/ijms20030467 |