دورية أكاديمية
Evaluating the therapeutic potential of one-carbon donors in nonalcoholic fatty liver disease.
| العنوان: | Evaluating the therapeutic potential of one-carbon donors in nonalcoholic fatty liver disease. |
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| المؤلفون: | Bakir MB; Department of Pharmacology and Experimental Therapeutics, Medical Research Institute, Alexandria University, Alexandria, Egypt., Salama MA; Department of Pharmacology and Experimental Therapeutics, Medical Research Institute, Alexandria University, Alexandria, Egypt., Refaat R; Department of Pharmacology and Experimental Therapeutics, Medical Research Institute, Alexandria University, Alexandria, Egypt., Ali MA; Department of Pharmacology & Therapeutics, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt. Electronic address: mennaallah.ismail@pua.edu.eg., Khalifa EA; Department of Histochemistry and Cell Biology, Medical Research Institute, Alexandria University, Alexandria, Egypt., Kamel MA; Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt. |
| المصدر: | European journal of pharmacology [Eur J Pharmacol] 2019 Mar 15; Vol. 847, pp. 72-82. Date of Electronic Publication: 2019 Jan 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Amsterdam : Elsevier Science Original Publication: Amsterdam, North Holland Pub. Co. |
| مواضيع طبية MeSH: | Carbon/*pharmacology , Liver/*drug effects , Non-alcoholic Fatty Liver Disease/*drug therapy, Animals ; Betaine/pharmacology ; Choline/pharmacology ; DNA Methylation/drug effects ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Folic Acid/pharmacology ; Glutathione/metabolism ; Homocysteine/metabolism ; Liver/metabolism ; Male ; Non-alcoholic Fatty Liver Disease/metabolism ; Rats ; Rats, Wistar ; S-Adenosylmethionine/metabolism |
| مستخلص: | Defect in one-carbon metabolism is one of the multiple underlying pathological pathways contributing to NAFLD pathogenesis. Hence, our study was designed to examine whether different one-carbon donors; betaine, choline, and folic acid would possess beneficial effects in NAFLD treatment. Rats were fed with high fat diet and NAFLD rats were orally treated with different doses of betaine or choline or folic acid for 28 days. All used one-carbon donors had dose-dependent ameliorating effects on NAFLD as they succeeded to reduce body and relative liver weights, serum lipids and liver enzymes. These were accompanied by decreasing hepatic fat accumulation and amending hepatic histological structure. They also improved serum and hepatic redox systems (total glutathione (tGSH), reduced GSH, oxidized GSSG, and GSH/GSSG ratio), hepatic S-adenosylmethionine/S-adenosyl homocysteine (SAM/SAH) ratio and increased hepatic global DNA methylation. There were some discrepancies in the dose and the extent of their effect, where folic acid showed the most prominent effects that could be mediated through the significant surge in hepatic SAM/SAH ratio and better efficient correction of one-carbon metabolism than the other donors. Thus, one-carbon donors can be strongly considered in NAFLD management and might influence the whole therapeutic approaches of fatty liver diseases. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Betaine; Choline; Folic acid; Global DNA methylation; S-adenosyl homocysteine; S-adenosylmethionine |
| المشرفين على المادة: | 0LVT1QZ0BA (Homocysteine) 3SCV180C9W (Betaine) 7440-44-0 (Carbon) 7LP2MPO46S (S-Adenosylmethionine) 935E97BOY8 (Folic Acid) GAN16C9B8O (Glutathione) N91BDP6H0X (Choline) |
| تواريخ الأحداث: | Date Created: 20190129 Date Completed: 20190604 Latest Revision: 20190604 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.ejphar.2019.01.039 |
| PMID: | 30689994 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0712 |
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| DOI: | 10.1016/j.ejphar.2019.01.039 |