دورية أكاديمية
Atypical hemolytic-uremic syndrome as one of the causes of acute kidney injury in pregnant women.
| العنوان: | Atypical hemolytic-uremic syndrome as one of the causes of acute kidney injury in pregnant women. |
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| المؤلفون: | Kozlovskaya NL; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia., Korotchaeva YV; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia., Shifman EM; M.F. Vladimirsky., Bobrova LA; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia. |
| المصدر: | Terapevticheskii arkhiv [Ter Arkh] 2018 Jun 20; Vol. 90 (6), pp. 28-34. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: ZAO 'Konsilium Medikum Country of Publication: Russia (Federation) NLM ID: 2984818R Publication Model: Print Cited Medium: Print ISSN: 0040-3660 (Print) Linking ISSN: 00403660 NLM ISO Abbreviation: Ter Arkh Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2018- > : Moskva : ZAO 'Konsilium Medikum' Original Publication: Moskva : Izdatelʹstvo Medit︠s︡ina |
| مواضيع طبية MeSH: | Acute Kidney Injury*/etiology , Acute Kidney Injury*/therapy , Atypical Hemolytic Uremic Syndrome*/complications , Kidney Failure, Chronic* , Pregnancy Complications*, Creatinine ; Female ; Humans ; Pregnancy ; Renal Dialysis |
| مستخلص: | Aim: Analysis of clinical manifestations, course and outcomes of obstetric aHUS. Materials and Methods: 45 patients with aHUS development during pregnancy or immediately after childbirth were observed between 2011 and 2017, age from 16 to 42 years. Results: All patients had AKI (serum creatinine 521,5±388,0 µmol/l, oliguria or anuria that required initiation of hemodialysis). 93.3% pts had extrarenal manifestations of TMA with the development of multiple organ failure (MOF). The mean number of damage organs was 3,7±1,2. In all patients, the development of aHUS was preceded by obstetric complications, surgery, infection, etc. In the outcome: 53.4% women showed complete recovery of renal function, 11.1% developed CKD 4-5 stages, 35.5% had dialysis-dependent end-stage renal failure (ESDR). Maternal mortality was 23.9%. Perinatal mortality was 32.6%. The early start of eculizumab treatment (within 1-2 weeks from the onset of aHUS), compared with therapy start after 3 weeks, increased the chances of favorable outcome for mother in 5.33 times, and the chances for normalization of renal function in 48.7 times. Conclusion: Obstetric aHUS is characterized by the development of AKI in 100% of cases. In most patients, the obstetric aHUS occurs with the development of MOF. Timely diagnosis of aHUS and immediate treatment by eculizumab allows not only to save the life of patients, but also completely restore their health. |
| فهرسة مساهمة: | Keywords: acute kidney injury; atypical hemolytic uremic syndrome; eculizumab; pregnancy |
| المشرفين على المادة: | AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 20190201 Date Completed: 20190617 Latest Revision: 20240801 |
| رمز التحديث: | 20240801 |
| DOI: | 10.26442/terarkh201890628-34 |
| PMID: | 30701901 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0040-3660 |
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| DOI: | 10.26442/terarkh201890628-34 |