دورية أكاديمية
In vivo actions of SCTR/AT1aR heteromer in controlling Vp expression and release via cFos/cAMP/CREB pathway in magnocellular neurons of PVN.
| العنوان: | In vivo actions of SCTR/AT1aR heteromer in controlling Vp expression and release via cFos/cAMP/CREB pathway in magnocellular neurons of PVN. |
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| المؤلفون: | Mak SOK; School of Biological Sciences, The University of Hong Kong, Hong Kong, China., Zhang L; Guangdong-Hong Kong-Macau (GHM) Institute of Central Nervous System (CNS) Regeneration, Jinan University, Guangzhou, China., Chow BKC; School of Biological Sciences, The University of Hong Kong, Hong Kong, China. |
| المصدر: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Apr; Vol. 33 (4), pp. 5389-5398. Date of Electronic Publication: 2019 Jan 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Bethesda, Md.] : Hoboken, NJ : Federation of American Societies for Experimental Biology ; Wiley Original Publication: [Bethesda, Md.] : The Federation, [c1987- |
| مواضيع طبية MeSH: | Cyclic AMP Response Element-Binding Protein/*metabolism , Paraventricular Hypothalamic Nucleus/*metabolism , Receptor, Angiotensin, Type 1/*metabolism , Signal Transduction/*physiology, Angiotensin II/metabolism ; Animals ; Genes, fos/genetics ; Hypothalamus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neurons ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Gastrointestinal Hormone/metabolism ; Secretin/metabolism ; Vasopressins/metabolism |
| مستخلص: | With an increasing body of evidence regarding GPCR oligomerization and its clinical implications over the last decade, the modulation and dynamics of GPCR homo- and hetero-oligomers has more recently become an area of intense research focus. Previously, our lab showed in vitro heteromer formation between angiotensin II receptor type 1 subtype a (AT1aR) and secretin receptor (SCTR), which is involved in in vivo control of hyperosmolality-induced water drinking behavior. Because the secretin (SCT)/SCTR axis is crucial to the central actions of angiotensin II (ANGII) and both SCT and ANGII are capable of triggering vasopressin (Vp) release from hypothalamus, we investigated here the in vivo role of SCTR-AT1aR heteromer in regulating Vp release in hypothalamus using transmembrane peptides as tools. We showed that SCTR-AT1aR heteromer mediates stimulatory actions of both SCT and ANGII in hypothalamic Vp expression and release as well as neuronal activities via the immediate early gene cFos. The results from this study not only are consistent with our hypothesis that SCT and ANGII interact at the receptor level to mediate their water homeostatic activities but also provide evidence for in vivo functions of cross-class GPCR heteromers.-Mak, S. O. K., Zhang, L., Chow, B. K. C. In vivo actions of SCTR/AT1aR heteromer in controlling Vp expression and release via cFos/cAMP/CREB pathway in magnocellular neurons of PVN. |
| فهرسة مساهمة: | Keywords: GPCR heteromerization; secretin receptor; transmembrane peptides; vasopressin |
| المشرفين على المادة: | 0 (Creb1 protein, mouse) 0 (Cyclic AMP Response Element-Binding Protein) 0 (Receptor, Angiotensin, Type 1) 0 (Receptors, G-Protein-Coupled) 0 (Receptors, Gastrointestinal Hormone) 0 (secretin receptor) 11000-17-2 (Vasopressins) 11128-99-7 (Angiotensin II) 1393-25-5 (Secretin) |
| تواريخ الأحداث: | Date Created: 20190201 Date Completed: 20200511 Latest Revision: 20200511 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1096/fj.201801732RR |
| PMID: | 30702925 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1530-6860 |
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| DOI: | 10.1096/fj.201801732RR |