دورية أكاديمية
Pan-genome analyses of model fungal species.
العنوان: | Pan-genome analyses of model fungal species. |
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المؤلفون: | McCarthy CGP; 1Genome Evolution Laboratory, Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.; 2Human Health Research Institute, Maynooth University, Maynooth, Co. Kildare, Ireland., Fitzpatrick DA; 1Genome Evolution Laboratory, Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.; 2Human Health Research Institute, Maynooth University, Maynooth, Co. Kildare, Ireland. |
المصدر: | Microbial genomics [Microb Genom] 2019 Feb; Vol. 5 (2). Date of Electronic Publication: 2019 Feb 04. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Microbiology Society Country of Publication: England NLM ID: 101671820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2057-5858 (Electronic) Linking ISSN: 20575858 NLM ISO Abbreviation: Microb Genom Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Oct. 2015- : [London] : Microbiology Society Original Publication: [London] : Society for General Microbiology, [2015]- |
مواضيع طبية MeSH: | Genome, Fungal*, Fungi/*classification, Evolution, Molecular ; Fungi/genetics ; Genome-Wide Association Study ; Genomics ; Phylogeny |
مستخلص: | The concept of the species 'pan-genome', the union of 'core' conserved genes and all 'accessory' non-conserved genes across all strains of a species, was first proposed in prokaryotes to account for intraspecific variability. Species pan-genomes have been extensively studied in prokaryotes, but evidence of species pan-genomes has also been demonstrated in eukaryotes such as plants and fungi. Using a previously published methodology based on sequence homology and conserved microsynteny, in addition to bespoke pipelines, we have investigated the pan-genomes of four model fungal species: Saccharomyces cerevisiae, Candida albicans, Cryptococcus neoformans var. grubii and Aspergillus fumigatus. Between 80 and 90 % of gene models per strain in each of these species are core genes that are highly conserved across all strains of that species, many of which are involved in housekeeping and conserved survival processes. In many of these species, the remaining 'accessory' gene models are clustered within subterminal regions and may be involved in pathogenesis and antimicrobial resistance. Analysis of the ancestry of species core and accessory genomes suggests that fungal pan-genomes evolve by strain-level innovations such as gene duplication as opposed to wide-scale horizontal gene transfer. Our findings lend further supporting evidence to the existence of species pan-genomes in eukaryote taxa. |
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فهرسة مساهمة: | Keywords: Aspergillus; Cryptococcus; comparative genomics; fungal pangenomes; yeast |
تواريخ الأحداث: | Date Created: 20190205 Date Completed: 20190913 Latest Revision: 20210109 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC6421352 |
DOI: | 10.1099/mgen.0.000243 |
PMID: | 30714895 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2057-5858 |
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DOI: | 10.1099/mgen.0.000243 |