دورية أكاديمية
أعرض في EDS

Immunomic Identification of Malaria Antigens Associated With Protection in Mice.

التفاصيل البيبلوغرافية
العنوان: Immunomic Identification of Malaria Antigens Associated With Protection in Mice.
المؤلفون: Siau A; From the ‡Nanyang Technological University, School of Biological Sciences, Singapore;. Electronic address: asiau@ntu.edu.sg., Huang X; From the ‡Nanyang Technological University, School of Biological Sciences, Singapore;; From the ‡Nanyang Technological University, School of Biological Sciences, Singapore., Loh HP; From the ‡Nanyang Technological University, School of Biological Sciences, Singapore;; From the ‡Nanyang Technological University, School of Biological Sciences, Singapore., Zhang N; From the ‡Nanyang Technological University, School of Biological Sciences, Singapore., Meng W; From the ‡Nanyang Technological University, School of Biological Sciences, Singapore., Sze SK; From the ‡Nanyang Technological University, School of Biological Sciences, Singapore., Renia L; §Singapore Immunology Network (SIgN), A*STAR, Biopolis, Singapore., Preiser P; From the ‡Nanyang Technological University, School of Biological Sciences, Singapore;. Electronic address: prpreiser@ntu.edu.sg.
المصدر: Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2019 May; Vol. 18 (5), pp. 837-853. Date of Electronic Publication: 2019 Feb 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 101125647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-9484 (Electronic) Linking ISSN: 15359476 NLM ISO Abbreviation: Mol Cell Proteomics Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology
Original Publication: Bethesda, MD : American Society for Biochemistry and Molecular Biology, [2002-
مواضيع طبية MeSH: Antigens, Protozoan/*immunology , Malaria/*immunology , Malaria/*prevention & control, Animals ; Antigens, Protozoan/chemistry ; CHO Cells ; Cricetinae ; Cricetulus ; Erythrocyte Membrane/metabolism ; Immune Sera ; Malaria/blood ; Merozoites/growth & development ; Merozoites/immunology ; Mice, Inbred BALB C ; Parasites/growth & development ; Plasmodium/growth & development ; Plasmodium/immunology ; Protein Denaturation ; Protein Domains ; Proteomics ; Protozoan Proteins/chemistry ; Protozoan Proteins/metabolism ; Reproducibility of Results
مستخلص: Efforts to develop vaccines against malaria represent a major research target. The observations that 1) sterile protection can be obtained when the host is exposed to live parasites and 2) the immunity against blood stage parasite is principally mediated by protective antibodies suggest that a protective vaccine is feasible. However, only a small number of proteins have been investigated so far and most of the Plasmodium proteome has yet to be explored. To date, only few immunodominant antigens have emerged for testing in clinical trials but no formulation has led to substantial protection in humans. The nature of parasite molecules associated with protection remains elusive. Here, immunomic screening of mice immune sera with different protection efficiencies against the whole parasite proteome allowed us to identify a large repertoire of antigens validated by screening a library expressing antigens. The calculation of weighted scores reflecting the likelihood of protection of each antigen using five predictive criteria derived from immunomic and proteomic data sets, highlighted a priority list of protective antigens. Altogether, the approach sheds light on conserved antigens across Plasmodium that are amenable to targeting by the host immune system upon merozoite invasion and blood stage development. Most of these antigens have preliminary protection data but have not been widely considered as candidate for vaccine trials, opening new perspectives that overcome the limited choice of immunodominant, poorly protective vaccines currently being the focus of malaria vaccine researches.
(© 2019 Siau et al.)
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فهرسة مساهمة: Keywords: 2D western blot; Antibodies*; Blood*; Immunology*; Infectious disease; LC-MS/MS; Label-free quantification; Malaria; Mouse models; Plasma or serum analysis; immunomic; immunoprecipitation; plasmodium
المشرفين على المادة: 0 (Antigens, Protozoan)
0 (Immune Sera)
0 (Protozoan Proteins)
تواريخ الأحداث: Date Created: 20190206 Date Completed: 20200116 Latest Revision: 20210325
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6495258
DOI: 10.1074/mcp.RA118.000997
PMID: 30718293
قاعدة البيانات: MEDLINE
الوصف
تدمد:1535-9484
DOI:10.1074/mcp.RA118.000997