دورية أكاديمية
أعرض في EDS

Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer's Disease.

التفاصيل البيبلوغرافية
العنوان: Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer's Disease.
المؤلفون: Stimmell AC; Department of Psychology, Program in Neuroscience, Florida State University, Tallahassee, Florida, USA. astimmell@neuro.fsu.edu., Baglietto-Vargas D; Neurobiology and Behavior, University of California Irvine, Irvine, California, USA., Moseley SC; Department of Psychology, Program in Neuroscience, Florida State University, Tallahassee, Florida, USA., Lapointe V; Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada., Thompson LM; Department of Psychology, Program in Neuroscience, Florida State University, Tallahassee, Florida, USA., LaFerla FM; Neurobiology and Behavior, University of California Irvine, Irvine, California, USA., McNaughton BL; Neurobiology and Behavior, University of California Irvine, Irvine, California, USA.; Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada., Wilber AA; Department of Psychology, Program in Neuroscience, Florida State University, Tallahassee, Florida, USA. awilber@fsu.edu.
المصدر: Scientific reports [Sci Rep] 2019 Feb 04; Vol. 9 (1), pp. 1311. Date of Electronic Publication: 2019 Feb 04.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Alzheimer Disease/*etiology , Alzheimer Disease/*physiopathology, Alzheimer Disease/metabolism ; Animals ; Behavior, Animal ; Biomarkers ; Disease Models, Animal ; Female ; Genotype ; Immunohistochemistry ; Male ; Mice ; Mice, Transgenic ; Space Perception
مستخلص: In early Alzheimer's disease (AD) spatial navigation is impaired; however, the precise cause of this impairment is unclear. Recent evidence suggests that getting lost is one of the first impairments to emerge in AD. It is possible that getting lost represents a failure to use distal cues to get oriented in space. Therefore, we set out to look for impaired use of distal cues for spatial orientation in a mouse model of amyloidosis (3xTg-AD). To do this, we trained mice to shuttle to the end of a track and back to an enclosed start box to receive a water reward. Then, mice were trained to stop in an unmarked reward zone to receive a brain stimulation reward. The time required to remain in the zone for a reward was increased across training, and the track was positioned in a random start location for each trial. We found that 6-month female, but not 3-month female, 6-month male, or 12-month male, 3xTg-AD mice were impaired. 6-month male and female mice had only intracellular pathology and male mice had less pathology, particularly in the dorsal hippocampus. Thus, AD may cause spatial disorientation as a result of impaired use of landmarks.
References: Med Princ Pract. 2015;24(1):1-10. (PMID: 25471398)
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7863-8. (PMID: 18505838)
PLoS One. 2013 Nov 13;8(11):e80355. (PMID: 24236177)
Behav Brain Res. 2015 Aug 1;289:29-38. (PMID: 25896362)
Behav Brain Res. 2015 Mar 15;281:156-71. (PMID: 25446741)
Ann Neurol. 1990 May;27(5):457-64. (PMID: 2360787)
Behav Brain Res. 2017 Jul 28;331:54-66. (PMID: 28511979)
Elife. 2013 Jun 25;2:e00647. (PMID: 23805379)
Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9697-701. (PMID: 7568200)
Neuron. 2005 Mar 3;45(5):675-88. (PMID: 15748844)
Aging Cell. 2018 Aug;17(4):e12791. (PMID: 29877034)
J Exp Psychol Anim Behav Process. 2007 Apr;33(2):100-14. (PMID: 17469959)
Acta Neuropathol. 1991;82(4):239-59. (PMID: 1759558)
Neurology. 2001 Jan 9;56(1):127-9. (PMID: 11148253)
Psychol Rev. 2007 Apr;114(2):340-75. (PMID: 17500630)
Hippocampus. 2017 Apr;27(4):378-392. (PMID: 28032686)
J Neurosci. 2018 Mar 21;38(12):2911-2919. (PMID: 29563239)
Curr Top Behav Neurosci. 2013;15:313-40. (PMID: 23670818)
Ann Neurol. 2002 Feb;51(2):182-9. (PMID: 11835374)
Front Neurorobot. 2017 Feb 07;11:4. (PMID: 28223931)
Ageing Res Rev. 2013 Jan;12(1):201-13. (PMID: 22771718)
J Alzheimers Dis. 2017;59(3):883-892. (PMID: 28697554)
J Neurophysiol. 2018 Jun 1;119(6):2007-2029. (PMID: 29442559)
Eur J Neurosci. 2004 Feb;19(3):705-12. (PMID: 14984421)
Hippocampus. 2003;13(5):587-603. (PMID: 12921349)
J Alzheimers Dis. 2016 Feb 9;52(1):77-90. (PMID: 26967209)
J Neurosci. 2013 Apr 17;33(16):7027-37. (PMID: 23595760)
Nat Neurosci. 2014 Feb;17(2):304-11. (PMID: 24362760)
Behav Neurosci. 2018 Oct;132(5):416-429. (PMID: 30091619)
Trends Neurosci. 2017 Jun;40(6):347-357. (PMID: 28494972)
Neuron. 1999 Nov;24(3):521-9. (PMID: 10595506)
Neuron. 2017 Sep 13;95(6):1406-1419.e5. (PMID: 28910623)
Exp Neurol. 2007 May;205(1):166-76. (PMID: 17368447)
Nat Neurosci. 2003 Jun;6(6):609-15. (PMID: 12717437)
Nat Neurosci. 2012 Oct;15(10):1365-7. (PMID: 22960933)
Cereb Cortex. 1994 Jan-Feb;4(1):27-39. (PMID: 8180489)
Hippocampus. 2014 Aug;24(8):963-78. (PMID: 24752989)
Neurosci Biobehav Rev. 2007;31(1):125-47. (PMID: 17055579)
Front Genet. 2014 Apr 23;5:88. (PMID: 24795750)
Neurobiol Dis. 2007 Oct;28(1):76-82. (PMID: 17659878)
Arch Neurol. 1989 Apr;46(4):391-4. (PMID: 2705898)
J Alzheimers Dis. 2010;20 Suppl 2:S527-33. (PMID: 20442496)
Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2295-300. (PMID: 20133875)
Nat Commun. 2017 Nov 24;8(1):1752. (PMID: 29170377)
Nature. 2014 Apr 10;508(7495):207-14. (PMID: 24695228)
Cold Spring Harb Perspect Med. 2012 Apr;2(4):a006171. (PMID: 22474609)
Nature. 2019 Apr;568(7752):400-404. (PMID: 30944479)
Front Neurol. 2016 Dec 01;7:215. (PMID: 27990134)
J Neurosci. 2014 Apr 16;34(16):5431-46. (PMID: 24741034)
J Neurosci. 1993 Sep;13(9):3916-25. (PMID: 8366351)
J Physiol. 2016 Aug 15;594(16):4615-30. (PMID: 25480798)
Neuron. 2012 Feb 23;73(4):789-802. (PMID: 22365551)
Neuron. 2017 Feb 8;93(3):533-541.e5. (PMID: 28111080)
Nature. 2017 Jul 12;547(7662):153-155. (PMID: 28703214)
Hippocampus. 2013 Apr;23(4):253-67. (PMID: 23447419)
Neuron. 2006 Mar 2;49(5):747-56. (PMID: 16504949)
Neuron. 2003 Jul 31;39(3):409-21. (PMID: 12895417)
Neurobiol Learn Mem. 2009 Feb;91(2):179-85. (PMID: 18804545)
Nat Protoc. 2007;2(11):2987-95. (PMID: 18007634)
معلومات مُعتمدة: K99 AG049090 United States AG NIA NIH HHS; R01 AG027544 United States AG NIA NIH HHS; P01 AG000538 United States AG NIA NIH HHS; R00 AG049090 United States AG NIA NIH HHS
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20190206 Date Completed: 20201112 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC6361963
DOI: 10.1038/s41598-018-37151-z
PMID: 30718609
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-018-37151-z