دورية أكاديمية
Endothelium-Dependent Effects of Echinodorus grandiflorus (Cham. & Schltdl.) Micheli Mediated by M3-Muscarinic and B2-Bradykininergic Receptors on Peripheral Vascular Resistance and Its Modulatory Effects on K+ Channels in Mesenteric Vascular Beds.
| العنوان: | Endothelium-Dependent Effects of Echinodorus grandiflorus (Cham. & Schltdl.) Micheli Mediated by M3-Muscarinic and B2-Bradykininergic Receptors on Peripheral Vascular Resistance and Its Modulatory Effects on K+ Channels in Mesenteric Vascular Beds. |
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| المؤلفون: | de Carvalho ES; Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil., Tirloni CAS; Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil., Palozi RAC; Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil., Schaedler MI; Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil., Guarnier LP; Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil., Silva AO; Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil., Mota JDS; Centro de Estudos em Recursos Naturais, Universidade Estadual de Mato Grosso do Sul, Dourados, MS, Brazil., Cardoso CAL; Centro de Estudos em Recursos Naturais, Universidade Estadual de Mato Grosso do Sul, Dourados, MS, Brazil., de Barros ME; Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil., Gasparotto Junior A; Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil. |
| المصدر: | Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2019 Jan 02; Vol. 2019, pp. 4109810. Date of Electronic Publication: 2019 Jan 02 (Print Publication: 2019). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: eCollection Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : New York, NY : Hindawi Pub. Original Publication: Oxford, UK : Oxford University Press, c2004- |
| مستخلص: | This work provides the first demonstration that ethanolic extract (EEEG) obtained from Echinodorus grandiflorus leaves (EEEG) and its butanolic fraction (ButFr) has important vasodilatory effects on isolated mesenteric vascular beds (MVBs). First, the EEEG was obtained and a liquid-liquid fractionation was performed. EEEG and its resulting fractions were analyzed by high-performance liquid chromatography. Then, the vasodilatory effects of EEEG and their respective fractions were evaluated. Finally, the molecular mechanisms involved in the vasodilator responses of the EEEG and ButFr were also investigated. EEEG vasodilator response was estimated at ~11 and 18 mm Hg at doses of 0.1 and 0.3 mg, respectively. Moreover, it was found that ButFr was able to induce an expressive dose-dependent vasodilator response in MVBs. The PP reduction values for doses of 0.1 and 0.3 mg were ~10 and 28 mm Hg, respectively. Endothelium removal or inhibition of nitric oxide and prostaglandin synthase (by L-NAME plus indomethacin) inhibited the vasodilatory effects induced by ButFr or EEEG. The peak effect of ButFr and EEEG doses (0.1 and 0.3 mg) was decreased by ~100% (p < 0.001). The association of atropine plus HOE-140 fully inhibited EEEG and ButFr-induced vasodilation (p < 0.001). Moreover, perfusion with nutritive solution containing 40 mM KCl or previous treatment with tetraethylammonium completely blocked vasodilation induced by ButFr (p < 0.001). This study showed that EEEG and its ButFr have important vasodilatory effects by endothelial M3-muscarinic and B2-bradykininergic receptors inducing nitric oxide and prostacyclin release followed by K+ channels activation in the vascular smooth muscle. |
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| تواريخ الأحداث: | Date Created: 20190206 Latest Revision: 20231005 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC6334330 |
| DOI: | 10.1155/2019/4109810 |
| PMID: | 30719059 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1741-427X |
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| DOI: | 10.1155/2019/4109810 |