دورية أكاديمية
أعرض في EDS

Bone Health in Patients with Type 2 Diabetes Treated by Roux-En-Y Gastric Bypass and the Role of Diabetes Remission.

التفاصيل البيبلوغرافية
العنوان: Bone Health in Patients with Type 2 Diabetes Treated by Roux-En-Y Gastric Bypass and the Role of Diabetes Remission.
المؤلفون: Madsen LR; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark. leemas@rm.dk.; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 132, 8200, Aarhus N, Denmark. leemas@rm.dk., Espersen R; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 132, 8200, Aarhus N, Denmark., Ornstrup MJ; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark., Jørgensen NR; Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.; Odense Patient Data Explorative Network, Odense University Hospital/Institute of Clinical Research, B. Winsløws Vej 9 A, University of Southern Denmark, 5000, Odense C, Denmark., Langdahl BL; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 132, 8200, Aarhus N, Denmark., Richelsen B; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 132, 8200, Aarhus N, Denmark.
المصدر: Obesity surgery [Obes Surg] 2019 Jun; Vol. 29 (6), pp. 1823-1831.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9106714 Publication Model: Print Cited Medium: Internet ISSN: 1708-0428 (Electronic) Linking ISSN: 09608923 NLM ISO Abbreviation: Obes Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : New York : Springer Science + Business Media
Original Publication: Oxford, OX, UK : Rapid Communications of Oxford, [1991-
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*, Bone Diseases, Metabolic/*etiology , Obesity, Morbid/*surgery, Absorptiometry, Photon ; Body Mass Index ; Bone Density ; Cohort Studies ; Cross-Sectional Studies ; Female ; Gastric Bypass ; Humans ; Male ; Middle Aged ; Postoperative Period ; Remission Induction
مستخلص: Background: Roux-en-Y gastric bypass (RYGB) has been associated with negative effects on bone. Whether this association is affected by pre-surgical type 2 diabetes (T2D) and surgically induced diabetes remission is unknown.
Methods: In this cross-sectional, matched cohort study 6 years after RYGB, we investigated bone health in 96 individuals with body mass index (BMI) > 35 kg/m 2 and T2D (stratified on current diabetes status) treated by RYGB 6 years earlier compared with 49 non-operated individuals with T2D matched with respect to sex, age, and current BMI. Main outcome measures were areal and volumetric bone mineral density (aBMD and vBMD), bone turnover, and odds ratio of osteoporosis/osteopenia.
Results: The RYGB group had lower hip (0.916 vs 1.010 g/cm 2 , p < 0.001), forearm (0.497 g/cm 2 vs 0.554 g/cm 2 , p < 0.001) aBMD, (269.63 mg/cm 3 vs 306.07 mg/cm 3 , p < 0.001) tibial, and radial (238.57 mg/cm 3 vs 278.14 mg/cm 3 , p < 0.0001) vBMD than the control group. Relative to the control group, c-terminal cross-linked telopeptide, procollagen type I amino-terminal propeptide, and osteocalcin were 75%, 41%, and 72% higher in the RYGB group, respectively (all p < 0.001). Odds ratio for osteopenia/osteoporosis in operated individuals was 2.21 (95% CI 1.06; 4.79, p = 0.05). Overall, stratified analysis on current diabetes status did not alter these outcomes.
Conclusions: Individuals with T2D treated by RYGB, compared to individuals with T2D of similar age and body composition not treated by RYGB, have lower BMD, lower bone strength, and increased levels of several bone turnover markers. Bone health was not associated with current diabetes status in the RYGB group.
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فهرسة مساهمة: Keywords: Bariatric surgery; Bone turnover; Diabetes; Dual-energy X-ray absorptiometry; High-resolution peripheral quantitative computed tomography; Osteoporosis; Roux-en-Y gastric bypass; Type 2 diabetes
تواريخ الأحداث: Date Created: 20190206 Date Completed: 20200410 Latest Revision: 20200410
رمز التحديث: 20240628
DOI: 10.1007/s11695-019-03753-3
PMID: 30719648
قاعدة البيانات: MEDLINE
الوصف
تدمد:1708-0428
DOI:10.1007/s11695-019-03753-3