دورية أكاديمية
Mercury-induced inflammation and autoimmunity.
| العنوان: | Mercury-induced inflammation and autoimmunity. |
|---|---|
| المؤلفون: | Pollard KM; Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, 92037, United States of America. Electronic address: mpollard@scripps.edu., Cauvi DM; Department of Surgery and Center for Investigations of Health and Education Disparities, School of Medicine, University of California, San Diego, 9500 Gilman Drive #0739, La Jolla, CA 92093, United States of America. Electronic address: dcauvi@ucsd.edu., Toomey CB; Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive #0946, La Jolla, CA 92093. Electronic address: cbtoomey@ucsd.edu., Hultman P; Department of Experimental and Clinical Medicine, Linköping University, Linköping, Sweden. Electronic address: per.hultman@liu.se., Kono DH; Department of Immunology and Microbiology, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, 92037, United States of America. Electronic address: dkono@scripps.edu. |
| المصدر: | Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2019 Dec; Vol. 1863 (12), pp. 129299. Date of Electronic Publication: 2019 Feb 10. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8006 (Electronic) Linking ISSN: 03044165 NLM ISO Abbreviation: Biochim Biophys Acta Gen Subj Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
| مواضيع طبية MeSH: | Autoimmune Diseases*/chemically induced , Autoimmune Diseases*/genetics , Autoimmune Diseases*/pathology , Gene Expression Regulation*/drug effects , Gene Expression Regulation*/immunology, Autoimmunity/*drug effects , Mercury/*toxicity, Animals ; Cytokines/genetics ; Cytokines/immunology ; Disease Models, Animal ; Genome-Wide Association Study ; Humans ; Inflammation/chemically induced ; Inflammation/immunology ; Inflammation/pathology |
| مستخلص: | Background: Human exposure to mercury leads to a variety of pathologies involving numerous organ systems including the immune system. A paucity of epidemiological studies and suitable diagnostic criteria, however, has hampered collection of sufficient data to support a causative role for mercury in autoimmune diseases. Nevertheless, there is evidence that mercury exposure in humans is linked to markers of inflammation and autoimmunity. This is supported by experimental animal model studies, which convincingly demonstrate the biological plausibility of mercury as a factor in the pathogenesis of autoimmune disease. Scope of the Review: In this review, we focus on ability of mercury to elicit inflammatory and autoimmune responses in both humans and experimental animal models. Major Conclusions: Although subtle differences exist, the inflammatory and autoimmune responses elicited by mercury exposure in humans and experimental animal models show many similarities. Proinflammatory cytokine expression, lymphoproliferation, autoantibody production, and nephropathy are common outcomes. Animal studies have revealed significant strain dependent differences in inflammation and autoimmunity suggesting genetic regulation. This has been confirmed by the requirement for individual genes as well as genome wide association studies. Importantly, many of the genes required for mercury-induced inflammation and autoimmunity are also required for idiopathic systemic autoimmunity. A notable difference is that mercury-induced autoimmunity does not require type I IFN. This observation suggests that mercury-induced autoimmunity may arise by both common and specific pathways, thereby raising the possibility of devising criteria for environmentally associated autoimmunity. General Significance: Mercury exposure likely contributes to the pathogenesis of autoimmunity. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| References: | J Rheumatol. 2000 Feb;27(2):405-10. (PMID: 10685806) Histochem J. 1996 Mar;28(3):217-25. (PMID: 8735289) J Immunol. 1999 Jun 15;162(12):7162-70. (PMID: 10358162) Toxicol Sci. 2014 Dec;142(2):339-49. (PMID: 25237059) Lancet. 2005 Dec 17;366(9503):2070-2. (PMID: 16360774) Toxicol Sci. 2007 Oct;99(2):512-21. (PMID: 17656488) Am J Pathol. 1988 Jul;132(1):110-8. (PMID: 3394794) Toxicol Sci. 2017 Jul 1;158(1):227-239. (PMID: 28453771) Scand J Immunol. 1995 Mar;41(3):268-72. (PMID: 7871386) J Immunol. 1998 Jul 1;161(1):234-40. (PMID: 9647229) J Immunol. 1991 May 1;146(9):3006-11. (PMID: 2016536) J Autoimmun. 2012 Dec;39(4):323-31. (PMID: 22578563) Int Arch Allergy Appl Immunol. 1984;73(2):162-5. (PMID: 6229494) Environ Res. 2014 Jul;132:12-8. (PMID: 24742722) J Immunol. 2000 Aug 15;165(4):2263-70. (PMID: 10925315) Int J Mol Sci. 2017 May 12;18(5):null. (PMID: 28498320) Clin Exp Immunol. 2009 Mar;155(3):567-76. (PMID: 19077085) Clin Immunol Immunopathol. 1992 Nov;65(2):98-109. (PMID: 1395135) Pol J Pathol. 2014 Dec;65(4):322-6. (PMID: 25693087) Occup Environ Med. 1997 Jun;54(6):437-42. (PMID: 9245951) Ann N Y Acad Sci. 1957 Apr 11;65(5):498-503. (PMID: 13411945) Autoimmun Rev. 2017 Jan;16(1):72-80. (PMID: 27666813) Int Arch Allergy Appl Immunol. 1982;69(1):12-7. (PMID: 6213563) Clin Exp Immunol. 2001 Oct;126(1):157-64. (PMID: 11678913) Curr Opin Toxicol. 2018 Aug;10:15-22. (PMID: 29503968) Curr Opin Immunol. 2016 Oct;42:25-30. (PMID: 27228132) J Exp Med. 1996 Apr 1;183(4):1473-81. (PMID: 8666905) Int Arch Allergy Appl Immunol. 1984;75(1):16-9. (PMID: 6086532) Lab Invest. 1978 Oct;39(4):405-11. (PMID: 309027) Int J Immunopharmacol. 1998 Dec;20(12):697-707. (PMID: 9877281) Arch Toxicol. 1993;67(3):205-11. (PMID: 7684221) Environ Res. 2017 Jul;156:334-340. (PMID: 28390301) J Immunol. 1997 Apr 1;158(7):3521-8. (PMID: 9120314) J Immunol. 1995 Apr 1;154(7):3138-46. (PMID: 7897203) Toxicol Lett. 2018 Oct 1;295:54-63. (PMID: 29859861) Cell. 2014 Jul 3;158(1):132-42. (PMID: 24995984) Int Immunopharmacol. 2001 Mar;1(3):581-93. (PMID: 11367541) Front Immunol. 2018 Mar 01;9:401. (PMID: 29545808) Eur J Immunol. 1977 Jun;7(6):348-51. (PMID: 302206) Immunopharmacology. 1994 Nov-Dec;28(3):201-8. (PMID: 7852051) J Cell Biol. 1969 Mar;40(3):847-50. (PMID: 5765770) J Autoimmun. 1997 Aug;10(4):347-55. (PMID: 9237798) Arthritis Rheum. 2007 May;56(5):1721; author reply 1721-2. (PMID: 17469167) J Immunol. 2004 Nov 1;173(9):5880-7. (PMID: 15494542) J Proteomics. 2018 Feb 20;173:107-114. (PMID: 29199152) Int J Environ Health Res. 2006 Aug;16(4):255-62. (PMID: 16854670) J Immunotoxicol. 2015;12(4):368-75. (PMID: 25477026) Cytokine. 1996 Oct;8(10):767-71. (PMID: 8980878) Int Arch Allergy Appl Immunol. 1970;37(1):76-87. (PMID: 5410774) West J Med. 2000 Jul;173(1):15-8; discussion 19. (PMID: 10903281) Tissue Antigens. 2003 Dec;62(6):449-58. (PMID: 14617028) J Autoimmun. 1996 Apr;9(2):139-49. (PMID: 8738957) J Immunol. 2003 Aug 1;171(3):1596-601. (PMID: 12874254) Arch Toxicol. 2016 Mar;90(3):543-50. (PMID: 25701957) Environ Health Perspect. 2016 Apr;124(4):426-36. (PMID: 26252071) Environ Health Perspect. 2001 Jan;109(1):27-33. (PMID: 11171521) Clin Immunol Immunopathol. 1978 Apr;9(4):464-81. (PMID: 648040) Toxicol Sci. 2014 Nov;142(1):158-66. (PMID: 25124724) Ann Am Thorac Soc. 2018 Apr;15(Suppl 2):S81-S85. (PMID: 29676647) Immunology. 2012 Apr;135(4):333-43. (PMID: 22136142) J Autoimmun. 1997 Oct;10(5):441-6. (PMID: 9376071) Toxicol Appl Pharmacol. 2003 Jul 15;190(2):146-56. (PMID: 12878044) Am J Pathol. 1988 Oct;133(1):127-38. (PMID: 3052091) J Immunol. 2005 Mar 1;174(5):3117-21. (PMID: 15728528) Immunobiology. 1987 Nov;175(5):455-69. (PMID: 2448223) FASEB J. 2009 Jun;23(6):1663-71. (PMID: 19168706) Clin J Am Soc Nephrol. 2010 Mar;5(3):439-44. (PMID: 20089494) J Autoimmun. 1995 Dec;8(6):809-23. (PMID: 8824708) Environ Res. 2017 Nov;159:545-554. (PMID: 28889024) J Autoimmun. 2001 Aug;17(1):27-37. (PMID: 11488635) Clin Exp Immunol. 1989 Dec;78(3):470-7. (PMID: 2612058) PLoS One. 2014 Aug 14;9(8):e104484. (PMID: 25122007) Environ Health Perspect. 2015 Aug;123(8):792-8. (PMID: 25665152) PLoS One. 2018 Jul 17;13(7):e0199979. (PMID: 30016332) Am J Kidney Dis. 2013 Jul;62(1):135-8. (PMID: 23602193) Met Ions Biol Syst. 1997;34:421-40. (PMID: 9046578) Autoimmune Dis. 2014;2014:325461. (PMID: 24864198) J Prev Med Public Health. 2014 Mar;47(2):74-83. (PMID: 24744824) Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12061-6. (PMID: 19574451) Am J Pathol. 1971 Nov;65(2):293-302. (PMID: 4109193) Hum Exp Toxicol. 2012 Apr;31(4):376-86. (PMID: 21558144) Sci Total Environ. 2014 Oct 15;496:636-643. (PMID: 24846746) J Immunol. 2001 Aug 15;167(4):2396-403. (PMID: 11490030) Ann Clin Biochem. 2006 Jul;43(Pt 4):257-68. (PMID: 16824275) Toxicol Appl Pharmacol. 2017 Sep 1;330:22-29. (PMID: 28668464) Am J Public Health. 2009 Nov;99 Suppl 3:S550-8. (PMID: 19890157) Clin Exp Immunol. 2005 Sep;141(3):422-31. (PMID: 16045731) Toxicol Appl Pharmacol. 2014 Apr 1;276(1):47-54. (PMID: 24440445) J Immunol. 1995 Jan 15;154(2):961-71. (PMID: 7529293) J Clin Pathol. 1986 Feb;39(2):167-71. (PMID: 3950037) Toxicol In Vitro. 2015 Mar;29(2):363-9. (PMID: 25458486) J Immunol. 2017 Dec 1;199(11):3739-3747. (PMID: 29055005) Environ Health Perspect. 1999 Oct;107 Suppl 5:729-35. (PMID: 10502538) Scand J Work Environ Health. 1993 Dec;19(6):405-13. (PMID: 8153593) Clin Toxicol (Phila). 2011 Dec;49(10):886-91. (PMID: 22070559) Toxicol Appl Pharmacol. 1997 Mar;143(1):102-9. (PMID: 9073598) Clin Exp Immunol. 1995 Nov;102(2):229-30. (PMID: 7586670) Semin Nephrol. 2003 Sep;23(5):500-8. (PMID: 13680539) Clin Exp Immunol. 2002 Jan;127(1):12-9. (PMID: 11882027) J Autoimmun. 2012 Dec;39(4):253-8. (PMID: 22771005) J Immunol. 1994 Feb 1;152(3):1064-71. (PMID: 7507957) Toxicology. 1988 Aug;50(3):247-56. (PMID: 3394153) FEBS Lett. 1993 Feb 8;317(1-2):35-8. (PMID: 8381367) J Prev Med Public Health. 2012 Nov;45(6):344-52. (PMID: 23230464) Ann Saudi Med. 2014 May-Jun;34(3):257-61. (PMID: 25266189) Immunogenetics. 1984;20(3):227-36. (PMID: 6236149) Int J Immunopharmacol. 1988;10(4):475-84. (PMID: 3262595) Environ Res. 2010 May;110(4):345-54. (PMID: 20176347) J Immunotoxicol. 2011 Jul-Sep;8(3):228-37. (PMID: 21793797) Autoimmune Dis. 2014;2014:260613. (PMID: 24818014) Scand J Immunol. 2001 Jan;53(1):49-55. (PMID: 11169206) Clin Immunol Immunopathol. 1993 Jul;68(1):9-20. (PMID: 8513597) Environ Health Perspect. 2011 Dec;119(12):1733-8. (PMID: 21868305) Toxicol Appl Pharmacol. 1992 Apr;113(2):199-208. (PMID: 1532866) Environ Health Perspect. 2011 Feb;119(2):203-9. (PMID: 20923743) BMC Med. 2013 Apr 04;11:100. (PMID: 23557436) Proc Natl Acad Sci U S A. 1989 Jan;86(1):237-41. (PMID: 2521387) Toxicol Appl Pharmacol. 2001 Nov 1;176(3):162-8. (PMID: 11714248) Arthritis Rheum. 2007 Jun;56(6):1934-44. (PMID: 17530719) J Autoimmun. 2012 Dec;39(4):259-71. (PMID: 22739348) Ann Rheum Dis. 2019 May;78(5):e33. (PMID: 29574414) Toxicol Appl Pharmacol. 2005 Aug 15;206(3):334-42. (PMID: 16039944) Aquat Toxicol. 2004 Feb 10;66(2):197-204. (PMID: 15036874) Clin Immunol Immunopathol. 1997 Sep;84(3):328-37. (PMID: 9281392) Clin Exp Immunol. 1982 Jun;48(3):700-4. (PMID: 6214344) Genes Immun. 2013 Jun;14(4):258-67. (PMID: 23615071) J Immunol. 2008 Aug 1;181(3):1937-47. (PMID: 18641331) Scand J Immunol. 1999 Sep;50(3):233-41. (PMID: 10447931) J Immunol. 2005 Nov 1;175(9):6163-8. (PMID: 16237113) Toxicol Appl Pharmacol. 1995 Jun;132(2):299-309. (PMID: 7785057) J Immunol. 2006 Oct 15;177(8):5708-17. (PMID: 17015760) Clin Exp Immunol. 1984 Nov;58(2):300-6. (PMID: 6333944) Hong Kong Med J. 2006 Aug;12(4):316-8. (PMID: 16912361) Clin Exp Immunol. 1998 Oct;114(1):9-12. (PMID: 9764596) Genomics. 1996 Jan 1;31(1):111-4. (PMID: 8808287) Science. 2006 Dec 22;314(5807):1936-8. (PMID: 17185603) Environ Int. 2012 Apr;40:39-43. (PMID: 22280926) Clin Exp Immunol. 1977 Apr;28(1):173-9. (PMID: 324675) Toxicol Sci. 2006 Jan;89(1):145-53. (PMID: 16251484) Environ Health Perspect. 2014 Jul;122(7):667-72. (PMID: 24682486) Clin Exp Immunol. 1997 Jul;109(1):149-56. (PMID: 9218838) Environ Health. 2004 Nov 02;3(1):11. (PMID: 15522122) Cell Immunol. 1992 Nov;145(1):146-55. (PMID: 1423640) Int J Hyg Environ Health. 2013 Nov;216(6):721-7. (PMID: 23419585) Environ Res. 2011 May;111(4):584-9. (PMID: 21396635) |
| معلومات مُعتمدة: | R01 ES022625 United States ES NIEHS NIH HHS; R21 ES029263 United States ES NIEHS NIH HHS; UH2 ES027679 United States ES NIEHS NIH HHS; UH3 ES027679 United States ES NIEHS NIH HHS; R01 ES021464 United States ES NIEHS NIH HHS |
| فهرسة مساهمة: | Keywords: Animal model; Autoimmunity; Human; Inflammation; Mercury |
| المشرفين على المادة: | 0 (Cytokines) FXS1BY2PGL (Mercury) |
| تواريخ الأحداث: | Date Created: 20190212 Date Completed: 20200512 Latest Revision: 20201201 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6689266 |
| DOI: | 10.1016/j.bbagen.2019.02.001 |
| PMID: | 30742953 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-8006 |
|---|---|
| DOI: | 10.1016/j.bbagen.2019.02.001 |