دورية أكاديمية
Stage-dependent cardiac regeneration in Xenopus is regulated by thyroid hormone availability.
| العنوان: | Stage-dependent cardiac regeneration in Xenopus is regulated by thyroid hormone availability. |
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| المؤلفون: | Marshall LN; Evolution des Régulations Endocriniennes, Département Adaptation du vivant, CNRS UMR 7221, Muséum National d'Histoire Naturelle, Sorbonne Université, 75231 Paris, France., Vivien CJ; Evolution des Régulations Endocriniennes, Département Adaptation du vivant, CNRS UMR 7221, Muséum National d'Histoire Naturelle, Sorbonne Université, 75231 Paris, France.; Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC 3052, Australia., Girardot F; Evolution des Régulations Endocriniennes, Département Adaptation du vivant, CNRS UMR 7221, Muséum National d'Histoire Naturelle, Sorbonne Université, 75231 Paris, France., Péricard L; Evolution des Régulations Endocriniennes, Département Adaptation du vivant, CNRS UMR 7221, Muséum National d'Histoire Naturelle, Sorbonne Université, 75231 Paris, France., Scerbo P; Evolution des Régulations Endocriniennes, Département Adaptation du vivant, CNRS UMR 7221, Muséum National d'Histoire Naturelle, Sorbonne Université, 75231 Paris, France.; Institut Curie, CNRS UMR 3347, INSERM U1021, Centre Universitaire, F-91405 Orsay, France., Palmier K; Evolution des Régulations Endocriniennes, Département Adaptation du vivant, CNRS UMR 7221, Muséum National d'Histoire Naturelle, Sorbonne Université, 75231 Paris, France.; Institute for Integrative Biology of the Cell, Commissariat à l'Energie Atomique, CNRS UMR 9198, Université Paris Sud, Saclay, 91198 Gif-sur-Yvette, France., Demeneix BA; Evolution des Régulations Endocriniennes, Département Adaptation du vivant, CNRS UMR 7221, Muséum National d'Histoire Naturelle, Sorbonne Université, 75231 Paris, France., Coen L; Evolution des Régulations Endocriniennes, Département Adaptation du vivant, CNRS UMR 7221, Muséum National d'Histoire Naturelle, Sorbonne Université, 75231 Paris, France; coen@mnhn.fr. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Feb 26; Vol. 116 (9), pp. 3614-3623. Date of Electronic Publication: 2019 Feb 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Heart Failure/*prevention & control , Regeneration/*genetics , Thyroid Hormones/*metabolism , Xenopus laevis/*genetics, Animals ; Gene Expression Regulation, Developmental/drug effects ; Heart Failure/physiopathology ; Humans ; Larva/genetics ; Larva/growth & development ; Metamorphosis, Biological/genetics ; Mice ; Salamandridae/genetics ; Salamandridae/growth & development ; Thyroid Hormones/administration & dosage ; Thyroid Hormones/genetics ; Xenopus laevis/growth & development ; Zebrafish/genetics ; Zebrafish/growth & development |
| مستخلص: | Despite therapeutic advances, heart failure is the major cause of morbidity and mortality worldwide, but why cardiac regenerative capacity is lost in adult humans remains an enigma. Cardiac regenerative capacity widely varies across vertebrates. Zebrafish and newt hearts regenerate throughout life. In mice, this ability is lost in the first postnatal week, a period physiologically similar to thyroid hormone (TH)-regulated metamorphosis in anuran amphibians. We thus assessed heart regeneration in Xenopus laevis before, during, and after TH-dependent metamorphosis. We found that tadpoles display efficient cardiac regeneration, but this capacity is abrogated during the metamorphic larval-to-adult switch. Therefore, we examined the consequence of TH excess and deprivation on the efficiently regenerating tadpole heart. We found that either acute TH treatment or blocking TH production before resection significantly but differentially altered gene expression and kinetics of extracellular matrix components deposition, and negatively impacted myocardial wall closure, both resulting in an impeded regenerative process. However, neither treatment significantly influenced DNA synthesis or mitosis in cardiac tissue after amputation. Overall, our data highlight an unexplored role of TH availability in modulating the cardiac regenerative outcome, and present X. laevis as an alternative model to decipher the developmental switches underlying stage-dependent constraint on cardiac regeneration. Competing Interests: The authors declare no conflict of interest. |
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| فهرسة مساهمة: | Keywords: Xenopus; cardiac regeneration; extracellular matrix; metamorphosis; thyroid hormone |
| المشرفين على المادة: | 0 (Thyroid Hormones) |
| تواريخ الأحداث: | Date Created: 20190214 Date Completed: 20190502 Latest Revision: 20200225 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6397552 |
| DOI: | 10.1073/pnas.1803794116 |
| PMID: | 30755533 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.1803794116 |