دورية أكاديمية
Visceral leishmaniasis with haemophagocytic lymphohistiocytosis.
| العنوان: | Visceral leishmaniasis with haemophagocytic lymphohistiocytosis. |
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| المؤلفون: | George JT; Department of General Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India., Sadiq M; Department of General Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India., Sigamani E; Department of Pathology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India., Mathuram AJ; Department of General Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. |
| المصدر: | BMJ case reports [BMJ Case Rep] 2019 Feb 13; Vol. 12 (2). Date of Electronic Publication: 2019 Feb 13. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BMJ Pub. Group |
| مواضيع طبية MeSH: | Amphotericin B/*administration & dosage , Hydrocortisone/*administration & dosage , Leishmaniasis, Visceral/*drug therapy , Lymphohistiocytosis, Hemophagocytic/*drug therapy, Administration, Intravenous ; Adult ; Amphotericin B/therapeutic use ; Bone Marrow Examination ; Fever/etiology ; Humans ; Hydrocortisone/therapeutic use ; Leishmania donovani/isolation & purification ; Leishmaniasis, Visceral/complications ; Lymphohistiocytosis, Hemophagocytic/etiology ; Male |
| مستخلص: | A 27-year-old man presented with high-grade intermittent fever for 4 months, generalised fatigue for 2 months, intermittent gum bleeds for 1 month and loss of weight of 15 kg. He appeared cachectic with generalised wasting, had pallor and features of reticuloendothelial system proliferation. His liver span was 17 cm. He had massive splenomegaly. His cardiovascular, respiratory and neurological examination were normal. He was diagnosed to have visceral leishmaniasis (VL) based on bone marrow (BM) examination that showed Leishmania donovani (LD) bodies and was treated with liposomal amphotericin (LA). During the course of therapy, he developed bleeding from various mucosal and venepuncture sites. His further evaluation, which included a repeat BM aspirate, showed haemophagocytes. Final diagnosis made was VL with secondary haemophagocytic lymphohistiocytosis. He was continued on LA with intravenous hydrocortisone. He developed refractory distributive shock with multiorgan dysfunction and succumbed to his illness. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.) |
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| فهرسة مساهمة: | Keywords: immunology; medical management; tropical medicine (infectious disease) |
| المشرفين على المادة: | 0 (liposomal amphotericin B) 7XU7A7DROE (Amphotericin B) WI4X0X7BPJ (Hydrocortisone) |
| تواريخ الأحداث: | Date Created: 20190216 Date Completed: 20190529 Latest Revision: 20210213 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6381973 |
| DOI: | 10.1136/bcr-2018-226361 |
| PMID: | 30765439 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1757-790X |
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| DOI: | 10.1136/bcr-2018-226361 |