دورية أكاديمية
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Acute and sub-acute toxicity of aqueous extract of aerial parts of Caralluma dalzielii N. E. Brown in mice and rats.

التفاصيل البيبلوغرافية
العنوان: Acute and sub-acute toxicity of aqueous extract of aerial parts of Caralluma dalzielii N. E. Brown in mice and rats.
المؤلفون: Ugwah-Oguejiofor CJ; Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, P.M.B. 2346 Sokoto, Nigeria., Okoli CO; Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria., Ugwah MO; Department of Pharmacy, Usmanu Danfodiyo University Teaching Hospital, P.M.B. 2346 Sokoto, Nigeria., Umaru ML; Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, P.M.B. 2346 Sokoto, Nigeria., Ogbulie CS; Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, P.M.B. 2346 Sokoto, Nigeria., Mshelia HE; Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, P.M.B. 2346 Sokoto, Nigeria., Umar M; Department of Morbid Anatomy and Forensic Medicine, Faculty of Basic Clinical Sciences, College of Health Sciences Usmanu Danfodiyo University, P.M.B. 2346 Sokoto, Nigeria., Njan AA; Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences College of Health Sciences, University of Ilorin, Kwara State, Nigeria.
المصدر: Heliyon [Heliyon] 2019 Jan 29; Vol. 5 (1), pp. e01179. Date of Electronic Publication: 2019 Jan 29 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Caralluma dalzielii N. E. Brown (Asclepiadaceae) is a cactus-like shaped shrub widely used in traditional medicine for the treatment of rheumatoid arthritis, diabetes, infertility and impotence. The present study evaluated the potential toxicity of aqueous extract of aerial parts of Caralluma dalzielii (AECD) through acute and sub-acute oral administration in mice and rats. During acute toxicity study, female mice and rats were orally administered with AECD at single doses of 175, 500 and 2000 mg/kg according to OECD Guidelines 425. Sub-acute toxicity of AECD (150, 300 and 600 mg/kg p.o) was studied by daily dosing of Wistar rats of both sexes for 28 days. The acute toxicity study revealed no lethal effects and behavioural signs of toxicity at the tested doses indicating that LD 50 is greater than 2000 mg/kg. In sub-acute study, a significant reduction in the body weight ( p < 0.05), feed and water ( p < 0.001) intake of the rats were observed. A significant ( p < 0.05) increase in lymphocytes, mean platelet volume counts and alanine aminotransferase were also observed. Histopathological analysis showed mild liver cell distortion in female rats treated at 600 mg/kg of AECD. These results show low toxicity of AECD on short-term use and liver toxicity on long-term use.
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فهرسة مساهمة: Keywords: Toxicology
تواريخ الأحداث: Date Created: 20190219 Latest Revision: 20200929
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6356088
DOI: 10.1016/j.heliyon.2019.e01179
PMID: 30775575
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2019.e01179