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Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.

التفاصيل البيبلوغرافية
العنوان: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
المؤلفون: Daya M; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA., Rafaels N; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA., Brunetti TM; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA., Chavan S; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA., Levin AM; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA., Shetty A; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA., Gignoux CR; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA., Boorgula MP; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA., Wojcik G; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Campbell M; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA., Vergara C; Department of Medicine, Johns Hopkins University, Baltimore, MD, 21224, USA., Torgerson DG; Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Ortega VE; Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, USA., Doumatey A; Center for Research on Genomics & Global Health, National Institutes of Health, Bethesda, MD, 20892, USA., Johnston HR; Department of Human Genetics, Emory University, Atlanta, GA, 30322, USA., Acevedo N; Institute for Immunological Research, Universidad de Cartagena, Cartagena, 130000, Colombia., Araujo MI; Immunology Service, Universidade Federal da Bahia, Salvador, 401110170, Brazil., Avila PC; Department of Medicine, Northwestern University, Chicago, IL, 60611, USA., Belbin G; Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Bleecker E; Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA., Bustamante C; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Caraballo L; Institute for Immunological Research, Universidad de Cartagena, Cartagena, 130000, Colombia., Cruz A; Universidade Federal da Bahia, Salvador, 401110170, Brazil., Dunston GM; Department of Microbiology, Howard University College of Medicine, Washington, DC, 20059, USA., Eng C; Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Faruque MU; National Human Genome Center, Howard University College of Medicine, Washington, DC, 20059, USA., Ferguson TS; Caribbean Institute for Health Research, The University of the West Indies, Kingston, 00007, Jamaica., Figueiredo C; Departamento de Biorregulacao, Universidade Federal da Bahia, Salvador, 401110170, Brazil., Ford JG; Department of Medicine, Einstein Medical Center, Philadelphia, PA, 19141, USA., Gan W; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Gourraud PA; Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR, 1064, ATIP-Avenir, Equipe 5, Nantes, France., Hansel NN; Department of Medicine, Johns Hopkins University, Baltimore, MD, 21224, USA., Hernandez RD; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, 94143, USA., Herrera-Paz EF; Facultad de Medicina, Universidad Católica de Honduras, San Pedro Sula, 21102, Honduras.; Universidad Tecnológica Centroamericana (UNITEC), Facultad de Ciencias Médicas, Tegucigalpa, Honduras., Jiménez S; Institute for Immunological Research, Universidad de Cartagena, Cartagena, 130000, Colombia., Kenny EE; Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Knight-Madden J; Caribbean Institute for Health Research, The University of the West Indies, Kingston, 00007, Jamaica., Kumar R; Department of Pediatrics, Northwestern University, Chicago, IL, 60611, USA., Lange LA; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA., Lange EM; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA., Lizee A; Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR, 1064, ATIP-Avenir, Equipe 5, Nantes, France., Maul P; Genetics and Epidemiology of Asthma in Barbados, The University of the West Indies, Chronic Disease Research Centre, Jemmots Lane, St. Michael, BB11115, Barbados., Maul T; Genetics and Epidemiology of Asthma in Barbados, The University of the West Indies, Chronic Disease Research Centre, Jemmots Lane, St. Michael, BB11115, Barbados., Mayorga A; Centro de Neumologia y Alergias, San Pedro Sula, 21102, Honduras., Meyers D; Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA., Nicolae DL; Department of Medicine, University of Chicago, Chicago, IL, 60637, USA., O'Connor TD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Oliveira RR; Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, Salvador, 40296-710, Brazil., Olopade CO; Department of Medicine and Center for Global Health, University of Chicago, Chicago, IL, 60637, USA., Olopade O; Department of Medicine, University of Chicago, Chicago, IL, 60637, USA., Qin ZS; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, 30322, USA., Rotimi C; Center for Research on Genomics & Global Health, National Institutes of Health, Bethesda, MD, 20892, USA., Vince N; Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR, 1064, ATIP-Avenir, Equipe 5, Nantes, France., Watson H; Faculty of Medical Sciences, The University of the West Indies, Queen Elizabeth Hospital, Bridgetown, St. Michael, BB11000, Barbados., Wilks RJ; Caribbean Institute for Health Research, The University of the West Indies, Kingston, 00007, Jamaica., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Salzberg S; Departments of Biomedical Engineering and Biostatistics, Johns Hopkins University, Baltimore, MD, 21205, USA., Ober C; Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA., Burchard EG; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, 94143, USA., Williams LK; Center for Individualized and Genomic Medicine Research, Henry Ford Health System, Detroit, MI, 48202, USA., Beaty TH; Department of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, MD, 21205, USA., Taub MA; Department of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, MD, 21205, USA., Ruczinski I; Department of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, MD, 21205, USA., Mathias RA; Department of Medicine, Johns Hopkins University, Baltimore, MD, 21224, USA., Barnes KC; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA. kathleen.barnes@ucdenver.edu.
مؤلفون مشاركون: CAAPA
المصدر: Nature communications [Nat Commun] 2019 Feb 20; Vol. 10 (1), pp. 880. Date of Electronic Publication: 2019 Feb 20.
نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Black or African American/*genetics , Asthma/*genetics , Genetic Predisposition to Disease/*genetics, Asthma/epidemiology ; Chromosomes, Human, Pair 12/genetics ; Chromosomes, Human, Pair 17/genetics ; Chromosomes, Human, Pair 8/genetics ; Genetic Loci ; Genome-Wide Association Study ; Hispanic or Latino/genetics ; Humans ; Polymorphism, Single Nucleotide/genetics ; United States/epidemiology
مستخلص: Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
التعليقات: Erratum in: Nat Commun. 2019 Sep 4;10(1):4082. (PMID: 31484942)
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معلومات مُعتمدة: R01 GM116065 United States GM NIGMS NIH HHS; R01 DK113003 United States DK NIDDK NIH HHS; R01 HL141845 United States HL NHLBI NIH HHS; S10 OD018522 United States OD NIH HHS; U19 AI106683 United States AI NIAID NIH HHS; P01 AI145818 United States AI NIAID NIH HHS; R01 HL112088 United States HL NHLBI NIH HHS; R01 AI079139 United States AI NIAID NIH HHS; R01 HL104608 United States HL NHLBI NIH HHS; R01 AI132476 United States AI NIAID NIH HHS; R37 HL068546 United States HL NHLBI NIH HHS; P20 GM121334 United States GM NIGMS NIH HHS; R01 HL129239 United States HL NHLBI NIH HHS; U54 GM115428 United States GM NIGMS NIH HHS; R01 HL118267 United States HL NHLBI NIH HHS
فهرسة مساهمة: Investigator: AA Adegnika; G Arinola; U Ateba-Ngoa; G Ayestas; H Bjarnadóttir; A Correa; SOL Erazo; MG Foreman; C Foster; L Gao; J Gao; L Grammer; M Hansen; T Hartert; Y Hu; I Königsberg; KA Kim; P Landaverde-Torres; J Marrugo; B Martinez; R Martinez; LF Mayorga; DA Mejia-Mejia; C Meza; S Musani; S Musharoff; O Oluwole; M Pino-Yanes; H Ramos; A Saenz; M Samms-Vaughan; R Schleimer; AF Scott; SS Shringarpure; W Song; ZA Szpiech; R Torres; G Varela; OM Vasquez; FM Vega; LB Ware; M Yazdanbakhsh
تواريخ الأحداث: Date Created: 20190222 Date Completed: 20190403 Latest Revision: 20221214
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6382865
DOI: 10.1038/s41467-019-08469-7
PMID: 30787307
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-019-08469-7