دورية أكاديمية
أعرض في EDS

High-fat diet aggravates the liver disease caused by periodontitis in rats.

التفاصيل البيبلوغرافية
العنوان: High-fat diet aggravates the liver disease caused by periodontitis in rats.
المؤلفون: Andrade RSB; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Piauí, Parnaíba, Piauí, Brazil., França LFC; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Piauí, Parnaíba, Piauí, Brazil., Pessoa LDS; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Piauí, Parnaíba, Piauí, Brazil., Landim BAA; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Piauí, Parnaíba, Piauí, Brazil., Rodrigues AA; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Piauí, Parnaíba, Piauí, Brazil., Alves EHP; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Piauí, Parnaíba, Piauí, Brazil., Lenardo DD; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Piauí, Parnaíba, Piauí, Brazil., Nascimento HMS; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Piauí, Parnaíba, Piauí, Brazil., Sousa FBM; Laboratory of Experimental Physiopharmacology (LAFFEX), Federal University of Piauí, Parnaíba, Piauí, Brazil., Barbosa ALDR; Laboratory of Experimental Physiopharmacology (LAFFEX), Federal University of Piauí, Parnaíba, Piauí, Brazil., Medeiros JR; Laboratory of Experimental Physiopharmacology (LAFFEX), Federal University of Piauí, Parnaíba, Piauí, Brazil., Vasconcelos ACCG; Medicine School, Education Institute of Parnaiba Valley (IESVAP), Parnaíba, Piauí, Brazil., Vasconcelos DFP; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Piauí, Parnaíba, Piauí, Brazil.
المصدر: Journal of periodontology [J Periodontol] 2019 Sep; Vol. 90 (9), pp. 1023-1031. Date of Electronic Publication: 2019 May 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Academy of Periodontology Country of Publication: United States NLM ID: 8000345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-3670 (Electronic) Linking ISSN: 00223492 NLM ISO Abbreviation: J Periodontol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Chicago] American Academy of Periodontology.
مواضيع طبية MeSH: Liver Diseases* , Periodontitis*, Alanine Transaminase ; Animals ; Aspartate Aminotransferases ; Diet, High-Fat ; Female ; Rats ; Rats, Wistar
مستخلص: Background: Periodontitis is an inflammatory disease that causes periodontium and hepatic alterations. Liver disease is related to the intake of foods rich in fat and sugars (high-fat). The objective of this study was to evaluate whether a high-fat diet can aggravate the liver disease caused by ligature-induced periodontitis in rats.
Methods: Twenty-one female rats were divided into three groups (n = 7 in each group): control; periodontitis (periodontitis induced with ligature) and high-fat + periodontitis (received hypercaloric diet and induction of periodontitis). The rats were submitted to the analyses of the following periodontal parameters: gingival bleeding index (GBI), probing pocket depth (PPD), tooth mobility (TM), and alveolar bone height. In the hepatic tissue, the levels of malondialdehyde (MDA), glutathione (GSH), total cholesterol, and myeloperoxidase activity (MPO) were measured. Liver samples were also histopathologically evaluated. Finally, blood levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose, total cholesterol, cholesterol high-density lipoprotein (HDL), and uric acid were measured.
Results: The high-fat + periodontitis group presented an increase in the steatosis score (P < 0.05) for the histopathologic evaluation, when compared with the periodontitis group. MDA, uric acid and ALT levels also increased, whereas GSH and HDL levels showed lower values.
Conclusion: A high-fat diet aggravates the liver disease caused by ligature-induced periodontitis in rats.
(© 2019 American Academy of Periodontology.)
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فهرسة مساهمة: Keywords: diet; diet therapy; fatty liver; periodontal diseases; periodontal medicine; periodontitis
المشرفين على المادة: EC 2.6.1.1 (Aspartate Aminotransferases)
EC 2.6.1.2 (Alanine Transaminase)
تواريخ الأحداث: Date Created: 20190226 Date Completed: 20200407 Latest Revision: 20200408
رمز التحديث: 20231215
DOI: 10.1002/JPER.18-0564
PMID: 30801719
قاعدة البيانات: MEDLINE
الوصف
تدمد:1943-3670
DOI:10.1002/JPER.18-0564