دورية أكاديمية
أعرض في EDS

Age- and sex-dependent profiles of APP fragments and key secretases align with changes in despair-like behavior and cognition in young APPSwe/Ind mice.

التفاصيل البيبلوغرافية
العنوان: Age- and sex-dependent profiles of APP fragments and key secretases align with changes in despair-like behavior and cognition in young APPSwe/Ind mice.
المؤلفون: Quartey MO; Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada., Nyarko JNK; Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada., Pennington PR; Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada., Heistad RM; Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada., Chaharyn BM; Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada., Wei Z; Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada., Bainbridge D; Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada., Baker GB; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Canada., Mousseau DD; Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada. Electronic address: darrell.mousseau@usask.ca.
المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2019 Apr 02; Vol. 511 (2), pp. 454-459. Date of Electronic Publication: 2019 Feb 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
أسماء مطبوعة: Publication: <2002- >: San Diego, CA : Elsevier
Original Publication: New York, Academic Press.
مواضيع طبية MeSH: Alzheimer Disease/*pathology , Amyloid beta-Peptides/*analysis , Cognitive Dysfunction/*pathology , Depression/*pathology , Peptide Fragments/*analysis, Aging ; Alzheimer Disease/complications ; Animals ; Brain/pathology ; Cognitive Dysfunction/complications ; Depression/complications ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Mice, Transgenic
مستخلص: Biological sex exerts distinct influences on brain levels of the β-amyloid (Aβ) peptide in both clinical depression and Alzheimer disease (AD), yet studies in animal models focus primarily on males. We examined behavioral 'despair'/depression (using the tail-suspension test) and memory (using the novel object recognition task) in J20 (hAPP Swe/Ind ) mice. Three month-old male (but not female) J20 mice exhibited less despair-like behavior, but more evidence of cognitive deficits. In young J20 mice, only soluble Aβ peptides -primarily Aβ(1-40)- were detected. There was no evidence of an effect on despair-like behavior in the six month-old J20 mice, although cognitive deficits were now evident in both sexes, and coincided with a greater proportion of the neurotoxic Aβ(1-42) species (in soluble as well as insoluble fractions). This age-dependent shift in Aβ peptide profile coincided with reduced expression of glycosylated species of ADAM-10 (α-secretase) and BACE1 (β-secretase), and an increased co-immunoprecipitation of presenilin-1 with nicastrin (components of the γ-secretase complex). Sex-dependent changes in depression-related monoaminergic, e.g. serotonin and dopamine (but not noradrenaline), systems were evident already in young J20 mice. It is critical to acknowledge that sex-dependent APP-related phenotypes might differentially influence modifiable depression-related monoaminergic signalling at some of the earliest pathological stages of clinical AD.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Alzheimer; Amyloid; Cortex; Depression; GABA; Monoamines; Sexual dimorphism
المشرفين على المادة: 0 (Amyloid beta-Peptides)
0 (Peptide Fragments)
0 (amyloid beta-protein (1-40))
0 (amyloid beta-protein (1-42))
تواريخ الأحداث: Date Created: 20190227 Date Completed: 20191216 Latest Revision: 20191217
رمز التحديث: 20240628
DOI: 10.1016/j.bbrc.2019.02.083
PMID: 30803762
قاعدة البيانات: MEDLINE
الوصف
تدمد:1090-2104
DOI:10.1016/j.bbrc.2019.02.083