دورية أكاديمية
Comparative evaluation of magnetic hyperthermia performance and biocompatibility of magnetite and novel Fe-doped hardystonite nanoparticles for potential bone cancer therapy.
| العنوان: | Comparative evaluation of magnetic hyperthermia performance and biocompatibility of magnetite and novel Fe-doped hardystonite nanoparticles for potential bone cancer therapy. |
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| المؤلفون: | Farzin A; Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA., Hassan S; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA., Emadi R; Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran., Etesami SA; Department of Mechanical Engineering, The University of Memphis, Memphis, TN 38152, USA., Ai J; Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: jafar_ai@tums.ac.ir. |
| المصدر: | Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2019 May; Vol. 98, pp. 930-938. Date of Electronic Publication: 2019 Jan 09. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101484109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0191 (Electronic) Linking ISSN: 09284931 NLM ISO Abbreviation: Mater Sci Eng C Mater Biol Appl Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
| مواضيع طبية MeSH: | Hyperthermia, Induced* , Magnetics*, Bone Neoplasms/*therapy , Iron/*pharmacology , Magnetite Nanoparticles/*chemistry , Silicates/*pharmacology, Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dynamic Light Scattering ; Humans ; Hydrogen-Ion Concentration ; Magnetite Nanoparticles/ultrastructure ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Powders ; X-Ray Diffraction |
| مستخلص: | Hyperthermia-increasing temperature of cancerous tissue for a short period of time-is considered as an effective treatment for various cancer types such as malignant bone tumors. Superparamagnetic and ferromagnetic particles have been studied for their hyperthermic properties in treating various types of cancers. The activation of magnetic nanoparticles by an alternating magnetic field is currently being explored as a technique for targeted therapeutic heating of different tumors and is being studied as an adjuvant to conventional chemotherapy and radiation therapy. In the case of bone cancers, to increase the efficiency of treatment in the hyperthermia therapy, employed materials should support bone regeneration as well. Magnetite is one of the most attractive magnetic nanoceramics used in hyperthermia application. However, biocompatibility and bioactivity of this material have raised questions. There is a high demand for extremely efficient hyperthermia materials which are equally biocompatible to non-tumor cells and tissues. We report the development of a biocompatible and bioactive material with desirable magnetic properties that show excellent hyperthermia properties and can be used for destruction of the cancerous tissue in addition to supporting tissue regeneration for treatment of bone tumors. In the current study, iron (Fe 3+ )-containing HT nanostructured material was prepared, and its biocompatibility, bioactivity, and hyperthermia abilities were studied. The developed materials showed effective hyperthermic properties with increased biocompatibility as compared to magnetite. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biocompatibility; Hardystonite; Hyperthermia; Magnetite |
| المشرفين على المادة: | 0 (Magnetite Nanoparticles) 0 (Powders) 0 (Silicates) 0 (hardystonite) E1UOL152H7 (Iron) |
| تواريخ الأحداث: | Date Created: 20190301 Date Completed: 20190624 Latest Revision: 20190624 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.msec.2019.01.038 |
| PMID: | 30813100 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-0191 |
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| DOI: | 10.1016/j.msec.2019.01.038 |