دورية أكاديمية
أعرض في EDS

Comparative evaluation of angiogenesis using a novel platelet-rich product: An in vitro study.

التفاصيل البيبلوغرافية
العنوان: Comparative evaluation of angiogenesis using a novel platelet-rich product: An in vitro study.
المؤلفون: Gomez TW; Department of Conservative and Endodontics, Noorul Islam College of Dental Science, Kerala University of Health Sciences, Thiruvananthapuram, Kerala, India., Gopal RV; Department of Conservative and Endodontics, Noorul Islam College of Dental Science, Kerala University of Health Sciences, Thiruvananthapuram, Kerala, India., Gaffoor FMA; Department of Conservative and Endodontics, Noorul Islam College of Dental Science, Kerala University of Health Sciences, Thiruvananthapuram, Kerala, India., Kumar STR; Department of Biotechnology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India., Girish CS; Department of Conservative and Endodontics, Noorul Islam College of Dental Science, Kerala University of Health Sciences, Thiruvananthapuram, Kerala, India., Prakash R; Department of Biotechnology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.
المصدر: Journal of conservative dentistry : JCD [J Conserv Dent] 2019 Jan-Feb; Vol. 22 (1), pp. 23-27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Country of Publication: India NLM ID: 101147009 Publication Model: Print Cited Medium: Print ISSN: 0972-0707 (Print) Linking ISSN: 09720707 NLM ISO Abbreviation: J Conserv Dent Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2008- : Mumbai Medknow
Original Publication: [Amritsar] : Federation of Operative Dentistry (India),
مستخلص: Background: In vivo angiogenesis is normal and vital process in growth and development, wound healing, and formation of granulation tissue wherein new blood vessels form from preexisting vessels as part of revascularization. Platelet-rich products promote wound healing associated with angiogenesis. Biomaterials such as titanium were found to be angiogenic. Unlike in vivo situations, in vitro angiogenesis, study cells, within a controlled environment.
Aims: The aim of this study is to evaluate the angiogenic potential of a novel platelet-rich product.
Materials and Methods: Blood was drawn from volunteers with informed consent. Blood samples were centrifuged to obtain platelet-rich products. Platelet concentrates prepared were platelet-rich plasma (PRP), platelet-rich fibrin, and a novel platelet-rich product which is titanium-prepared PRP (TPRP), obtained using titanium. The study which compared platelet concentrate was divided into four groups subjected to tissue culture. Phase-contrast microscope was used to determine the rate of growth by cell counting.
Statistical Analysis: ANOVA was used for comparison within groups and post hoc for multiple comparisons.
Results: TPRP group showed granular ground substance. Group with platelet-rich fibrin (PRF) shows a high rate of growth whereas those with TPRP showed better growth rate when compared to its counterpart, PRP.
Conclusions: This is the first study which introduces TPRP. Previous studies have proved that titanium-prepared PRF has better structural quality than its counterpart platelet-rich fibrin. This study concludes that TPRP has better angiogenic potential than its counterpart PRP. Further in vivo studies are needed to promote TPRP as a new generation of platelet products.
Competing Interests: There are no conflicts of interest.
References: Biomaterials. 2004 Aug;25(17):3485-92. (PMID: 15020122)
Biomaterials. 2004 Nov;25(26):5681-703. (PMID: 15147815)
Biomaterials. 2005 Apr;26(12):1397-403. (PMID: 15482827)
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e37-44. (PMID: 16504849)
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e56-60. (PMID: 16504852)
Biomaterials. 2007 Feb;28(6):966-74. (PMID: 17095084)
J Oral Maxillofac Surg. 2007 Jul;65(7 Suppl 1):64-72. (PMID: 17586351)
Growth Factors. 2009 Feb;27(1):63-9. (PMID: 19089687)
Foot Ankle Int. 2009 Nov;30(11):1101-6. (PMID: 19912722)
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jan;109(1):72-8. (PMID: 19926499)
Biomaterials. 2010 Jun;31(18):4909-17. (PMID: 20356623)
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Sep;110(3):275-8; author reply 278-80. (PMID: 20727495)
Regen Med. 2011 Jan;6(1):67-79. (PMID: 21175288)
Br J Oral Maxillofac Surg. 2013 Jul;51(5):438-43. (PMID: 22951383)
J Conserv Dent. 2012 Oct;15(4):395-8. (PMID: 23112492)
Arch Oral Biol. 2013 May;58(5):537-44. (PMID: 23141995)
Case Rep Dent. 2013;2013:410515. (PMID: 23533827)
Med Mol Morphol. 2014 Jun;47(2):83-9. (PMID: 23604952)
Int Endod J. 2014 Jan;47(1):41-9. (PMID: 23772873)
Exp Biol Med (Maywood). 2014 Nov;239(11):1476-88. (PMID: 24872440)
فهرسة مساهمة: Keywords: Angiogenesis; platelet-rich products; titanium
تواريخ الأحداث: Date Created: 20190302 Latest Revision: 20220408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6385567
DOI: 10.4103/JCD.JCD_216_18
PMID: 30820078
قاعدة البيانات: MEDLINE
الوصف
تدمد:0972-0707
DOI:10.4103/JCD.JCD_216_18