دورية أكاديمية
Pre-fracture medication use as a predictor of 30-day mortality in hip fracture patients: an analysis of 141,201 patients.
| العنوان: | Pre-fracture medication use as a predictor of 30-day mortality in hip fracture patients: an analysis of 141,201 patients. |
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| المؤلفون: | Jantzen C; Department of Orthopaedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark., Madsen CM; Department of Orthopaedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark., Abrahamsen B; Odense Patient Data Explorative Network, Institute of Clinical Research, University of Southern Denmark and Department of Medicine, Holbæk Hospital, Holbæk, Denmark., Van Der Mark S; Department of Orthopaedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark., Duus BR; Department of Orthopaedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark., Howland J; Department of Emergency Medicine, Boston University School of Medicine, MA, USA., Lauritzen JB; Department of Orthopaedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark., Jørgensen HL; Department of Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, Denmark. |
| المصدر: | Hip international : the journal of clinical and experimental research on hip pathology and therapy [Hip Int] 2020 Jan; Vol. 30 (1), pp. 101-106. Date of Electronic Publication: 2019 Mar 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publishing Country of Publication: United States NLM ID: 9200413 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-6067 (Electronic) Linking ISSN: 11207000 NLM ISO Abbreviation: Hip Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Thousand Oaks, CA : SAGE Publishing Original Publication: Milano, Italy : Wichtig, c1991- |
| مواضيع طبية MeSH: | Adrenergic beta-Antagonists/*adverse effects , Angiotensin-Converting Enzyme Inhibitors/*adverse effects , Calcium Channel Blockers/*adverse effects , Hip Fractures/*epidemiology, Aged ; Aged, 80 and over ; Comorbidity ; Denmark/epidemiology ; Female ; Hip Fractures/etiology ; Humans ; Male ; Middle Aged ; Survival Rate/trends |
| مستخلص: | Purpose: To evaluate the predictive value of pre-fracture medication usage on 30-day mortality following a hip fracture. Methods: Information on age, sex, fracture type, time of death and Charlson co-morbidity index (CCI) was collected from the Danish National Patient Registry on all patients above 60 years, sustaining a hip fracture during the period January 1995 to December 2013. Information on drug usage was obtained from the Danish National Prescription Database. Hazard ratios were calculated with 30-day mortality as the outcome. A univariate and 3 multivariate analyses were conducted with increasing adjustments, starting with age, sex and fracture type, adding co-morbidity and dose in the latter. Results: 141,201 patients were included and a total of 12 drugs/drug groups were identified for analysis. Increased mortality was evident in all analyses for antiarrhythmics, beta blockers, proton pump inhibitors, loop diuretics, opioids, acetaminophen and for psycholeptics. For ACE-inhibitors, increased mortality was found in all analyses, except after adjustment for co-morbidity and dose. For thiazide diuretics, a significantly reduced mortality was evident in all but the univariate analyses while NSAIDs and statins were associated with a significantly reduced mortality in all analyses. For calcium channel blockers, an insignificant decrease was found after adjustment for dose. Further analysis showed a dose-response relationship for all drugs except ACE-inhibitors and calcium channel blockers. Conclusion: The study shows a correlation between pre-fracture usage of certain drugs and 30 day mortality after a hip fracture. |
| فهرسة مساهمة: | Keywords: Drug usage; hip fracture; medication; mortality |
| المشرفين على المادة: | 0 (Adrenergic beta-Antagonists) 0 (Angiotensin-Converting Enzyme Inhibitors) 0 (Calcium Channel Blockers) |
| تواريخ الأحداث: | Date Created: 20190302 Date Completed: 20200824 Latest Revision: 20220412 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1177/1120700019832603 |
| PMID: | 30821177 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1724-6067 |
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| DOI: | 10.1177/1120700019832603 |