دورية أكاديمية
The pharmacokinetics of R- and S-tocainide in patients with acute ventricular arrhythmias.
| العنوان: | The pharmacokinetics of R- and S-tocainide in patients with acute ventricular arrhythmias. |
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| المؤلفون: | Thomson AH, Murdoch G, Pottage A, Kelman AW, Whiting B, Hillis WS |
| المصدر: | British journal of clinical pharmacology [Br J Clin Pharmacol] 1986 Feb; Vol. 21 (2), pp. 149-54. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print Cited Medium: Print ISSN: 0306-5251 (Print) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: London, Macmillan Journals Ltd. |
| مواضيع طبية MeSH: | Anti-Arrhythmia Agents/*blood , Arrhythmias, Cardiac/*drug therapy , Lidocaine/*analogs & derivatives, Acute Disease ; Aged ; Anti-Arrhythmia Agents/adverse effects ; Arrhythmias, Cardiac/blood ; Female ; Humans ; Kinetics ; Lidocaine/adverse effects ; Lidocaine/blood ; Male ; Middle Aged ; Stereoisomerism ; Time Factors ; Tocainide |
| مستخلص: | The pharmacokinetics of R(-) and S(+)- tocainide were studied in twelve patients requiring intravenous tocainide. In all patients, a progressive increase in the S(+):R(-) ratio was observed during the infusion. Mean +/- s.d. ratios increased from 1.03 +/- 0.05 at 2 min to 1.76 +/- 0.35 at 48.5 h. Data from eight patients were fitted to a two-compartment model and there was a significant difference (Wilcoxon matched-pairs test P less than 0.01) in the clearance estimates for the two enantiomers. The median values were: S(+)-tocainide = 6.25 l h-1 and R(-)-tocainide = 9.31 l h-1. There was no differences in V1 or Vss. |
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| المشرفين على المادة: | 0 (Anti-Arrhythmia Agents) 27DXO59SAN (Tocainide) 98PI200987 (Lidocaine) |
| تواريخ الأحداث: | Date Created: 19860201 Date Completed: 19860507 Latest Revision: 20190510 |
| رمز التحديث: | 20240627 |
| مُعرف محوري في PubMed: | PMC1400923 |
| DOI: | 10.1111/j.1365-2125.1986.tb05169.x |
| PMID: | 3082345 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0306-5251 |
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| DOI: | 10.1111/j.1365-2125.1986.tb05169.x |